INT62267

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Context Info
Confidence 0.12
First Reported 1996
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.82
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rb1) enzyme binding (Rb1) DNA binding (Rb1)
cell division (Rb1) transcription factor binding (Rb1)
Rb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 1 68.52 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 2 85.00 Quite High
Death 1 84.48 Quite High
Colon Cancer 3 79.08 Quite High
Cancer 2 75.00 Quite High
Familial Adenomatous Polyposis 1 74.56 Quite High
Polyps 1 72.64 Quite High
INFLAMMATION 1 68.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sulindac and sulindac sulfide decrease the levels of mitotic cyclins, induce the levels of p21WAF-1/cip1, and reduce the total levels of pRB, with a relative increase in the amount of the underphosphorylated form of pRB in a time- and concentration-dependent manner.
Negative_regulation (reduce) of Gene_expression (levels) of pRB
1) Confidence 0.12 Published 1996 Journal Oncogene Section Abstract Doc Link 8632912 Disease Relevance 0.82 Pain Relevance 0.07

General Comments

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