INT62268

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Context Info
Confidence 0.67
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 33
Total Number 33
Disease Relevance 14.12
Pain Relevance 3.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1a) nucleus (Cdkn1a) cell cycle (Cdkn1a)
kinase activity (Cdkn1a) cytoplasm (Cdkn1a)
Anatomy Link Frequency
neural 4
mononuclear cells 2
chondrocyte 1
cardiac myocyte 1
liver 1
Cdkn1a (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 24 99.12 Very High Very High Very High
Paracetamol 13 99.04 Very High Very High Very High
cINOD 4 87.40 High High
Central nervous system 6 84.72 Quite High
Chronic pancreatitis 16 84.64 Quite High
Multiple sclerosis 2 79.60 Quite High
Enkephalin 24 78.00 Quite High
Inflammation 8 71.16 Quite High
fibrosis 26 66.48 Quite High
imagery 13 65.84 Quite High
Disease Link Frequency Relevance Heat
Cancer 469 99.96 Very High Very High Very High
Apoptosis 218 99.80 Very High Very High Very High
Pancreatic Cancer 118 99.64 Very High Very High Very High
Reprotox - General 1 18 99.38 Very High Very High Very High
Myeloid Leukemia 23 98.96 Very High Very High Very High
Multiple Sclerosis 2 95.04 Very High Very High Very High
Hypertrophy 4 94.74 High High
Intestinal Cancer 2 94.08 High High
Stomach Cancer 146 93.96 High High
Repression 10 93.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Arvanil blocks the G1/S phase transition of the cell cycle in stimulated peripheral blood mononuclear cells, inducing activation of p21waf-1/cip-1 and phosphorylation of Akt/PKB.
Positive_regulation (activation) of p21waf in mononuclear cells
1) Confidence 0.67 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16239036 Disease Relevance 0.26 Pain Relevance 0.12
On day 2.5, lidocaine increased the levels of p21 protein.
Positive_regulation (increased) of p21
2) Confidence 0.66 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18931217 Disease Relevance 0 Pain Relevance 0
Higher doses of lidocaine arrest cell multiplication at the S-phase of the growth cycle by upregulation of p21, an extremely potent inhibitor of cell multiplication.
Positive_regulation (upregulation) of p21
3) Confidence 0.66 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18931217 Disease Relevance 0 Pain Relevance 0
Among these changes was induction of the cyclin-dependent kinase inhibitor, p21(WAF1/cip1).
Positive_regulation (induction) of p21
4) Confidence 0.50 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11507085 Disease Relevance 0.33 Pain Relevance 0.09
In contrast, activation of FGFR3 in the proliferative zone (Fig. 5), by FGF18 [84] inhibits chondrocyte proliferation via phosphorylation of STAT-1 and subsequent upregulation of p21WAF/CIP1, which can inhibit the cell cycle [85].
Positive_regulation (upregulation) of p21WAF in chondrocyte
5) Confidence 0.49 Published 2004 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840003 Disease Relevance 0.38 Pain Relevance 0
Our results show that Ikaros-1 is expressed in the boundary of the striatal germinal zone (GZ)/mantle zone (MZ), where it induces cell cycle arrest of neural progenitors by up-regulation of the cyclin-dependent kinase inhibitor (CDKi) p21(Cip1/Waf1).
Positive_regulation (up-regulation) of Cip1 in neural
6) Confidence 0.45 Published 2010 Journal J. Comp. Neurol. Section Abstract Doc Link 19950118 Disease Relevance 0.30 Pain Relevance 0.26
Our results show that Ikaros-1 is expressed in the boundary of the striatal germinal zone (GZ)/mantle zone (MZ), where it induces cell cycle arrest of neural progenitors by up-regulation of the cyclin-dependent kinase inhibitor (CDKi) p21(Cip1/Waf1).
Positive_regulation (up-regulation) of p21 in neural
7) Confidence 0.45 Published 2010 Journal J. Comp. Neurol. Section Abstract Doc Link 19950118 Disease Relevance 0.30 Pain Relevance 0.26
Our results show that Ikaros-1 is expressed in the boundary of the striatal germinal zone (GZ)/mantle zone (MZ), where it induces cell cycle arrest of neural progenitors by up-regulation of the cyclin-dependent kinase inhibitor (CDKi) p21(Cip1/Waf1).
Positive_regulation (up-regulation) of Waf1 in neural
8) Confidence 0.45 Published 2010 Journal J. Comp. Neurol. Section Abstract Doc Link 19950118 Disease Relevance 0.30 Pain Relevance 0.26
AMPK activation suppresses protein synthesis and prevents cardiac myocyte hypertrophy by regulation of the eEF2 kinase/eEF2 axis and/or TSC2-mTOR-P70S6 pathways.22-24) LKB1 has been reported to cause G1 growth arrest in cultured cells via induction of p21WAF1/CIP111) and stimulation of Brg1 ATPase.25) LKB1 kinase activity is required for p21WAF1/CIP1 induction, and overexpression of LKB1 causes p21WAF1/CIP1-induced growth arrest in cells with undetectable or low levels of endogenous LKB1.11) In contrast to kinase activity, although Brg1-associated growth arrest also requires LKB1 kinase activity, wild-type LKB1 and the kinase-deficient form LKB1-SL26 both stimulate Brg1 ATPase.25) This suggests that some regulatory functions of LKB1 may not require its kinase activity.19) As is well known, LKB1 has an autophosphorylation activity to increased its kinase activity.
Positive_regulation (induction) of CIP1 in cardiac myocyte associated with hypertrophy
9) Confidence 0.45 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.28 Pain Relevance 0
Our results show that Ikaros-1 is expressed in the boundary of the striatal germinal zone (GZ)/mantle zone (MZ), where it induces cell cycle arrest of neural progenitors by up-regulation of the cyclin-dependent kinase inhibitor (CDKi) p21(Cip1/Waf1).
Positive_regulation (up-regulation) of cyclin-dependent kinase inhibitor in neural
10) Confidence 0.39 Published 2010 Journal J. Comp. Neurol. Section Abstract Doc Link 19950118 Disease Relevance 0.30 Pain Relevance 0.26
The cyclin-dependent kinase inhibitor p21 was also induced in the liver following acetaminophen administration.
Positive_regulation (induced) of p21 in liver associated with paracetamol
11) Confidence 0.34 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14644624 Disease Relevance 0.55 Pain Relevance 0.62
Arvanil blocks the G1/S phase transition of the cell cycle in stimulated peripheral blood mononuclear cells, inducing activation of p21waf-1/cip-1 and phosphorylation of Akt/PKB.
Positive_regulation (activation) of cip-1 in mononuclear cells
12) Confidence 0.24 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16239036 Disease Relevance 0.26 Pain Relevance 0.12
G1 cell cycle arrest is, in most cases, a result of the induction of the CDKN1A gene, which encodes the cyclin-dependent kinase inhibitor WAF1 (also known as p21; Richon et al. 2000).
Positive_regulation (induction) of CDKN1A gene
13) Confidence 0.23 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.30 Pain Relevance 0
Since activating K-ras mutations are described in more than 80% of pancreatic cancers and are known to increase intracellular levels of p21WAF1/CIP1 in experimental models, the possible role of activating K-ras mutations in an induction of the p21WAF1/CIP1 expression was investigated in our study.
Positive_regulation (increase) of p21WAF1/CIP1 associated with pancreatic cancer
14) Confidence 0.20 Published 2003 Journal Neoplasma Section Abstract Doc Link 14628083 Disease Relevance 0.59 Pain Relevance 0.16
Immunoblot analysis showed that expression of c-Myc protein was significantly downregulated by ApoG2 and that the expression of c-Myc's downstream molecules cyclin D1 and cyclin E were inhibited whereas p21 was induced.
Positive_regulation (induced) of p21
15) Confidence 0.15 Published 2009 Journal J Transl Med Section Abstract Doc Link PMC2742515 Disease Relevance 0.75 Pain Relevance 0
Since activating K-ras mutations are described in more than 80% of pancreatic cancers and are known to increase intracellular levels of p21WAF1/CIP1 in experimental models, the possible role of activating K-ras mutations in an induction of the p21WAF1/CIP1 expression was investigated in our study.
Positive_regulation (increase) of p21WAF1/CIP1 associated with pancreatic cancer
16) Confidence 0.14 Published 2003 Journal Neoplasma Section Abstract Doc Link 14628083 Disease Relevance 0.59 Pain Relevance 0.16
Interestingly, Smad4/DPC4 also leads to the induction of p21/WAF1 so that Smad4 can contribute to the inhibition of cell cycle via the activation of WAF1 [14].
Positive_regulation (induction) of WAF1
17) Confidence 0.13 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 0.62 Pain Relevance 0.05
Methylation in the p21WAF1/cip1 promoter of Apc+/-, p21+/- mice and lack of response to sulindac.
Positive_regulation (Methylation) of p21WAF1/cip1
18) Confidence 0.13 Published 2005 Journal Oncogene Section Title Doc Link 15688007 Disease Relevance 0.46 Pain Relevance 0.08
Interestingly, Smad4/DPC4 also leads to the induction of p21/WAF1 so that Smad4 can contribute to the inhibition of cell cycle via the activation of WAF1 [14].
Positive_regulation (activation) of WAF1
19) Confidence 0.12 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 0.56 Pain Relevance 0
The

differential expression of apoptosis-related BAX and BCL-XL [19] and a dose-response relationship for the induction of CDKN1A,

Positive_regulation (induction) of CDKN1A associated with apoptosis
20) Confidence 0.11 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0.36 Pain Relevance 0.08

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