INT62269

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Context Info
Confidence 0.73
First Reported 1996
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 60
Total Number 62
Disease Relevance 35.78
Pain Relevance 9.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1a) nucleus (Cdkn1a) cell cycle (Cdkn1a)
kinase activity (Cdkn1a) cytoplasm (Cdkn1a)
Anatomy Link Frequency
colon 2
MCF-7 2
ducts 2
4T1 2
muscle 1
Cdkn1a (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 32 99.82 Very High Very High Very High
Chronic pancreatitis 74 99.52 Very High Very High Very High
Dismenorea 17 99.44 Very High Very High Very High
lidocaine 9 98.88 Very High Very High Very High
fluoxetine 22 97.24 Very High Very High Very High
Analgesic 2 96.86 Very High Very High Very High
Pain 8 96.32 Very High Very High Very High
local anesthetic 3 95.00 High High
imagery 26 88.04 High High
withdrawal 4 84.52 Quite High
Disease Link Frequency Relevance Heat
Cancer 533 100.00 Very High Very High Very High
Apoptosis 347 100.00 Very High Very High Very High
Endometriosis 24 100.00 Very High Very High Very High
Retinoblastoma 21 100.00 Very High Very High Very High
Infection 121 99.96 Very High Very High Very High
Adenocarcinoma 97 99.60 Very High Very High Very High
Pancreatitis 74 99.52 Very High Very High Very High
Reprotox - General 1 22 99.34 Very High Very High Very High
Malignant Neoplastic Disease 10 99.12 Very High Very High Very High
Myeloid Leukemia 37 98.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On day 1.5, lidocaine upregulated expression of cyclin-D1 and cyclin-dependent kinase inhibitor 1A [p21].
Gene_expression (expression) of p21
1) Confidence 0.73 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18931217 Disease Relevance 0 Pain Relevance 0
Lidocaine inhibits NIH-3T3 cell multiplication by increasing the expression of cyclin-dependent kinase inhibitor 1A (p21).
Gene_expression (expression) of p21 in NIH-3T3 associated with lidocaine
2) Confidence 0.73 Published 2008 Journal Anesth. Analg. Section Title Doc Link 18931217 Disease Relevance 0.09 Pain Relevance 0.38
Expression of proliferating cell nuclear antigen (PCNA) and cell cycle proteins cyclin D1 and p21 were not detectable in controls or after AAP alone.
Gene_expression (Expression) of p21 associated with paracetamol
3) Confidence 0.61 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12954812 Disease Relevance 0.43 Pain Relevance 0.75
Treatment with GSH after AAP induced expression of cyclin D1, p21, and PCNA (12-48 h).
Gene_expression (expression) of p21 associated with paracetamol
4) Confidence 0.61 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12954812 Disease Relevance 0.34 Pain Relevance 0.63
On day 2.5, lidocaine increased the levels of p21 protein.
Gene_expression (levels) of p21
5) Confidence 0.57 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18931217 Disease Relevance 0 Pain Relevance 0
Expression of proliferating cell nuclear antigen (PCNA) and cell cycle proteins cyclin D1 and p21 were not detectable in controls or after AAP alone.
Neg (not) Gene_expression (detectable) of p21 associated with paracetamol
6) Confidence 0.47 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12954812 Disease Relevance 0.41 Pain Relevance 0.63
CDKN1A reporter expression is enhanced after transfection with PBX1 and HOXA10, especially when MEIS1 was co-transfected (Bromleigh and Freedman, 2000).
Gene_expression (expression) of CDKN1A
7) Confidence 0.44 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.25 Pain Relevance 0
Finally, 4T1 displayed significantly reduced levels of CDK2-associated protein 1 (CDK2ap1), p53 and two p53 targets, cyclin-dependent kinase inhibitor p21 (Cdkn1a) and cyclin G (Ccng1) (Fig. 11C).
Gene_expression (levels) of Cdkn1a in 4T1
8) Confidence 0.35 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.31 Pain Relevance 0.03
Finally, 4T1 displayed significantly reduced levels of CDK2-associated protein 1 (CDK2ap1), p53 and two p53 targets, cyclin-dependent kinase inhibitor p21 (Cdkn1a) and cyclin G (Ccng1) (Fig. 11C).
Gene_expression (levels) of p21 in 4T1
9) Confidence 0.35 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.26 Pain Relevance 0.03
Pancreatic-derived factor (PANDER)-induced down-regulation of CDKN1A (cyclin-dependent kinase inhibitor 1A (P21)) expression coupled with induced CASP3-activation may serve a central role in islet cell death [132].
Gene_expression (expression) of CDKN1A associated with death
10) Confidence 0.35 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.68 Pain Relevance 0.03
We found the genes sparc, ednrb, junb, cdkn1a, bcl2, ccl5, abcc1 over-expressed and the genes sod1, s100a10 and fth1 under-expressed after inoculation of Tx2-6.
Gene_expression (expressed) of cdkn1a
11) Confidence 0.27 Published 2009 Journal Toxicon Section Abstract Doc Link 19524607 Disease Relevance 0.08 Pain Relevance 0.08
We found the genes sparc, ednrb, junb, cdkn1a, bcl2, ccl5, abcc1 over-expressed and the genes sod1, s100a10 and fth1 under-expressed after inoculation of Tx2-6.
Gene_expression (expressed) of cdkn1a
12) Confidence 0.27 Published 2009 Journal Toxicon Section Abstract Doc Link 19524607 Disease Relevance 0.08 Pain Relevance 0.08
As shown in fig. 4A, all these three oligonucleotides significantly suppressed the expression of c-Myc protein; the reduction in c-Myc expression led to upregulation of p21 expression and downregulation of cyclin D expression.
Gene_expression (expression) of p21
13) Confidence 0.26 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 0.48 Pain Relevance 0
Authors have reported that the oncoprotein c-Myc regulates the expression of p21 and cyclins, increases cyclin D-CDK4 activity, and facilitates cell cycle progression [15].
Gene_expression (expression) of p21
14) Confidence 0.26 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 0.49 Pain Relevance 0
Moreover, expression of p21 protein was upregulated as early as 24 h and gradually returned to low level at 72 h since most of the CNE-2 cells were dead at this time (Fig. 3B); unlike p21, expression of both cyclin D1 and cyclin E were downregulated following the degradation of c-Myc.
Gene_expression (expression) of p21
15) Confidence 0.26 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 0.32 Pain Relevance 0
is activated by gossypol in prostate cancer cells, and gossypol upregulates p21 expression and downregulates cyclin D1 and Rb expression in colon cancer cells [8,9].
Gene_expression (expression) of p21 in colon associated with colon cancer and reprotox - general 1
16) Confidence 0.26 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 1.06 Pain Relevance 0
However, Chang et al. found that gossypol did not affect cell cycle progression or the p53 or p21/WAF signaling pathway in A549 human alveolar lung cancer cells [10].
Gene_expression (progression) of p21 in lung associated with lung cancer
17) Confidence 0.22 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 1.24 Pain Relevance 0
Since activating K-ras mutations are described in more than 80% of pancreatic cancers and are known to increase intracellular levels of p21WAF1/CIP1 in experimental models, the possible role of activating K-ras mutations in an induction of the p21WAF1/CIP1 expression was investigated in our study.
Gene_expression (expression) of p21WAF1/CIP1 associated with pancreatic cancer
18) Confidence 0.22 Published 2003 Journal Neoplasma Section Abstract Doc Link 14628083 Disease Relevance 0.71 Pain Relevance 0.22
The possible role of activating K-ras mutations in an induction of p21WAF1/CIP1 expression was not confirmed in this study.
Gene_expression (expression) of p21WAF1/CIP1
19) Confidence 0.22 Published 2003 Journal Neoplasma Section Abstract Doc Link 14628083 Disease Relevance 0.89 Pain Relevance 0.22
Expression of p53 and p21WAF1/CIP1 was examined immunohistochemically and codon 12 K-ras mutational analysis was performed using the very sensitive mutant-enriched PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) analysis.
Spec (examined) Gene_expression (Expression) of p21WAF1/CIP1
20) Confidence 0.22 Published 2003 Journal Neoplasma Section Abstract Doc Link 14628083 Disease Relevance 0.87 Pain Relevance 0.24

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