INT62272

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Context Info
Confidence 0.57
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 6.46
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CDK1) mitochondrion (CDK1) protein complex assembly (CDK1)
cytoplasm (CDK1) cytosol (CDK1) mitosis (CDK1)
CDK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Taxol 2 80.76 Quite High
cINOD 10 74.64 Quite High
Kinase C 1 58.72 Quite High
cytokine 2 24.96 Low Low
antagonist 1 19.20 Low Low
metalloproteinase 15 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 405 98.78 Very High Very High Very High
Carcinoma 48 97.24 Very High Very High Very High
Infection 151 97.00 Very High Very High Very High
Breast Cancer 332 95.32 Very High Very High Very High
Apoptosis 85 94.60 High High
Malignant Neoplastic Disease 13 93.04 High High
Neuroblastoma 1 90.84 High High
Death 16 90.60 High High
Papillomavirus Infection 246 85.64 High High
Reprotox - General 1 58 85.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This block in cell cycle progression is associated with an initial rise, then an abrupt decrease in the levels of p34cdc2 protein.
Negative_regulation (decrease) of p34cdc2
1) Confidence 0.57 Published 1996 Journal Oncogene Section Abstract Doc Link 8632912 Disease Relevance 0.79 Pain Relevance 0.07
The S phase block was accompanied by a reduction in the protein levels of cyclin A, cyclin B1, cyclin D1, cdc2, PCNA and the c-jun AP-1 component.
Negative_regulation (reduction) of cdc2
2) Confidence 0.57 Published 2003 Journal Int. J. Cancer Section Abstract Doc Link 14566835 Disease Relevance 0.53 Pain Relevance 0.06
BRCA1 could be characterized as having a basal phenotype, ER-negative and HER2-negative, with up-regulation of cyclin A and caspase 3, but downregulation of cyclin D1 and D3, CDKIs (p16, p21, p27), and BCL2, the opposite phenotype from most BRCA2 carcinomas.
Negative_regulation (downregulation) of CDK associated with carcinoma
3) Confidence 0.57 Published 2006 Journal Proteome Sci Section Body Doc Link PMC1456950 Disease Relevance 1.12 Pain Relevance 0.20
High expression of p21 would result in decreased cell proliferation subsequent to inhibition of cyclin/CDK activity [20].
Negative_regulation (inhibition) of CDK
4) Confidence 0.57 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1563460 Disease Relevance 0.39 Pain Relevance 0
BRCA2 tumours expressed cyclin D1 and D3, cyclin D kinase (CDK) 4 and the CDK inhibitors, p16, p21, and p27, which were all downregulated in BRCA1.
Negative_regulation (inhibitors) of CDK associated with cancer
5) Confidence 0.41 Published 2006 Journal Proteome Sci Section Body Doc Link PMC1456950 Disease Relevance 1.11 Pain Relevance 0.05
This was associated with downregulation of the levels of cyclins D1 and B1, and with inhibition of CDK1, CDK2 and CDK4.
Negative_regulation (inhibition) of CDK1
6) Confidence 0.33 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.63 Pain Relevance 0.07
While the phosphorylation of NE components by CDK1 correlates with NE breakdown, and inhibition of cdk1 prevents NE breakdown [16],[17], some have argued that NE breakdown is initiated by mechanical tension induced by spindle microtubules, leading to holes in the NE [28],[29].
Negative_regulation (inhibition) of cdk1
7) Confidence 0.25 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2642596 Disease Relevance 0.59 Pain Relevance 0
Using a chemical inhibitor of CDK1, purvalanol A [19], we found that CDK1 activity is required for efficient infection by HPVs (Figure 6A).
Negative_regulation (inhibitor) of CDK1 associated with infection
8) Confidence 0.25 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2642596 Disease Relevance 0.42 Pain Relevance 0
The Cdc25 proteins are phosphatases that activate Cdc2; therefore, their inactivation by genistein thereby inactivates Cdc2 and induces G2/M-phase arrest.
Negative_regulation (inactivates) of Cdc2
9) Confidence 0.22 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.89 Pain Relevance 0

General Comments

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