INT62273

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Context Info
Confidence 0.75
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 8.43
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CDK1) mitochondrion (CDK1) protein complex assembly (CDK1)
cytoplasm (CDK1) cytosol (CDK1) mitosis (CDK1)
Anatomy Link Frequency
synovial cells 3
telomere 1
Upper 1
stem cells 1
CDK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 318 79.52 Quite High
cINOD 15 75.00 Quite High
Spinal cord 48 57.24 Quite High
Action potential 19 56.72 Quite High
antagonist 2 46.00 Quite Low
imagery 1 36.40 Quite Low
methotrexate 18 25.04 Quite Low
cytokine 52 25.00 Low Low
Inflammation 74 7.12 Low Low
dexamethasone 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 372 99.98 Very High Very High Very High
Breast Cancer 195 97.72 Very High Very High Very High
Hypoxia 140 96.80 Very High Very High Very High
Malignant Neoplastic Disease 12 92.04 High High
Apoptosis 99 90.48 High High
Death 45 89.96 High High
Contagious Ecthyma 1 85.52 High High
Aging 29 84.72 Quite High
Colon Cancer 13 84.56 Quite High
Polyploidy 24 84.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BRCA2 tumours expressed cyclin D1 and D3, cyclin D kinase (CDK) 4 and the CDK inhibitors, p16, p21, and p27, which were all downregulated in BRCA1.
Gene_expression (expressed) of CDK associated with cancer
1) Confidence 0.75 Published 2006 Journal Proteome Sci Section Body Doc Link PMC1456950 Disease Relevance 1.08 Pain Relevance 0.05
BRCA2 tumours expressed cyclin D1 and D3, cyclin D kinase (CDK) 4 and the CDK inhibitors, p16, p21, and p27, which were all downregulated in BRCA1.
Gene_expression (expressed) of CDK associated with cancer
2) Confidence 0.65 Published 2006 Journal Proteome Sci Section Body Doc Link PMC1456950 Disease Relevance 1.13 Pain Relevance 0.05
This block in cell cycle progression is associated with an initial rise, then an abrupt decrease in the levels of p34cdc2 protein.
Gene_expression (levels) of p34cdc2
3) Confidence 0.58 Published 1996 Journal Oncogene Section Abstract Doc Link 8632912 Disease Relevance 0.78 Pain Relevance 0.07
The S phase block was accompanied by a reduction in the protein levels of cyclin A, cyclin B1, cyclin D1, cdc2, PCNA and the c-jun AP-1 component.
Gene_expression (levels) of cdc2
4) Confidence 0.58 Published 2003 Journal Int. J. Cancer Section Abstract Doc Link 14566835 Disease Relevance 0.53 Pain Relevance 0.06
(B) Upper panel: autoradiograph of Cdc2 kinase activity (phosphorylation of histone H1) and immunoblot of Cdc2 kinase expression in lysates prepared from hFP-HEK and pCEP4-HEK cells that had been treated with either vehicle (V) or 1 ┬ÁM PGF2?
Gene_expression (expression) of Cdc2 in Upper
5) Confidence 0.40 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0 Pain Relevance 0
Expression of AR-regulated cell cycle genes, such as A-, B- and D-type cyclins, cyclin-dependent kinases (CDK1, CDK2, CDK4, CDK6) and cyclin-dependent kinase inhibitors (CDKN1B, CDKN2A, CDKN2B), was generally unaffected [40], [41], [42], [43], [44], [45].
Gene_expression (Expression) of CDK1
6) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0 Pain Relevance 0
However, as was previously observed [46], ectopic expression of human Cdk1, and to a lesser extent the HHV-5 CHPK permitted cell cycle progression through G1 and into S phase of cdc28-13 cells grown at the restrictive temperature, as evidenced by an increase in the number of budded cells (Fig. 4).
Gene_expression (expression) of Cdk1
7) Confidence 0.39 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2936540 Disease Relevance 0 Pain Relevance 0
It has been shown in vitro [98] that in synovial cells, the over-expression of CCNB1 and CDC2 leads to aberrant mitosis, recognizable by abundant cytoplasm, large pale nuclei and prominent nucleoli with karyotypic alteration.
Gene_expression (over) of CDC2 in synovial cells
8) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.28 Pain Relevance 0.10
It has been shown in vitro [98] that in synovial cells, the over-expression of CCNB1 and CDC2 leads to aberrant mitosis, recognizable by abundant cytoplasm, large pale nuclei and prominent nucleoli with karyotypic alteration.
Gene_expression (-) of CDC2 in synovial cells
9) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.28 Pain Relevance 0.10
It has been shown in vitro [98] that in synovial cells, the over-expression of CCNB1 and CDC2 leads to aberrant mitosis, recognizable by abundant cytoplasm, large pale nuclei and prominent nucleoli with karyotypic alteration.
Gene_expression (expression) of CDC2 in synovial cells
10) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.28 Pain Relevance 0.10
, cyclin B1 expression and Cdc2 kinase activity were assessed by immunoblot analysis and in vitro kinase assay, respectively.
Gene_expression (expression) of Cdc2
11) Confidence 0.35 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0 Pain Relevance 0
Low oxygen/DHP-d was determined to exert prominent effects on the overexpression of a variety of proliferation-associated genes, including RUNX3, CDK2, Cyclin D2, CDK1, and telomere reverse transcriptase (TERT; Figure 1E).
Gene_expression (overexpression) of CDK1 in telomere
12) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.58 Pain Relevance 0
Further, de-ATSC proliferation was also mediated by JAK/STAT3 phosphorylation along with Rex-1, CDK1, CDK2, and RUNX3 expression (Figure 3B).
Gene_expression (expression) of CDK1
13) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.49 Pain Relevance 0
When treated with JAKinase inhibitors, STAT3 phosphorylation and associated proliferation factors involving cell growth and CDK1, CDK2, Rex1, Nanog, and RUNX3 expression was decreased profoundly (Figure 3A and 3B, 3C).
Gene_expression (expression) of CDK1
14) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.53 Pain Relevance 0
delays mitosis and is associated with an increased expression of cyclin B1 and Cdc2 kinase activity.
Gene_expression (expression) of Cdc2
15) Confidence 0.14 Published 2005 Journal Cell Mol Life Sci Section Abstract Doc Link PMC2792351 Disease Relevance 0.41 Pain Relevance 0
Global gene expression analysis results showed that Oct4 regulated target genes which could be characterized as differentially regulated genes such as pluripotency markers NANOG, SOX2, and KLF4 and markers of undifferentiated stem cells FOXD1, CDC2, and EPHB1.
Gene_expression (markers) of CDC2 in stem cells
16) Confidence 0.12 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2747014 Disease Relevance 0.13 Pain Relevance 0.03
Both NF-Y and E2F have been shown to be crucial regulators of the cell-cycle-dependent expression of several genes such as cdc2, CDC25, cyclin E, cyclin A, cyclin B, topoisomerase II?
Gene_expression (expression) of cdc2
17) Confidence 0.12 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0.09 Pain Relevance 0
S1, in an experimental hypoxic and DHP-d-induced ROS scavenging environment, de-ATSC grew continuously for more than 3 months (>20 passages) and their cell cycle controlling factors such as CDK1, CDK2, and RUNX3 expression was prominently increased along with active growth activity compared to in the case of hypoxic or DHP-d single treatment (Fig.
Gene_expression (expression) of CDK1 associated with hypoxia
18) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 1.29 Pain Relevance 0.03
This induction increased expression of NAG-1 that was p53-independent and Sp1-dependent.
Gene_expression (expression) of Sp1-dependent
19) Confidence 0.01 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17715378 Disease Relevance 0.56 Pain Relevance 0.07

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