INT62274

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Context Info
Confidence 0.32
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 5.90
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (APOB) small molecule metabolic process (APOB) endoplasmic reticulum (APOB)
enzyme binding (APOB) lipid metabolic process (APOB) extracellular space (APOB)
Anatomy Link Frequency
bile 2
APOB (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 9 99.24 Very High Very High Very High
cINOD 1 61.08 Quite High
adenocard 3 53.12 Quite High
alcohol 8 52.96 Quite High
Inflammatory marker 3 33.68 Quite Low
Bioavailability 18 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 288 99.92 Very High Very High Very High
Mental Disorders 4 98.72 Very High Very High Very High
Obesity 33 94.32 High High
Hyperlipidemia 30 93.48 High High
Dyslipidemia /

Combined Dyslipidemia

72 91.28 High High
Hypertension 19 90.36 High High
Diabetes Mellitus 91 89.72 High High
Cardiovascular Disease 189 89.60 High High
Apoptosis 2 88.80 High High
Coronary Artery Disease 121 82.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
2.3.1 ApoB/ApoA1 ratio
Negative_regulation (2.3.1) of Gene_expression (ratio) of ApoB
1) Confidence 0.32 Published 2008 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC2601038 Disease Relevance 1.08 Pain Relevance 0.03
3.1 ApoB/ApoA1 ratio
Negative_regulation (3.1) of Gene_expression (ratio) of ApoB
2) Confidence 0.32 Published 2008 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC2601038 Disease Relevance 1.39 Pain Relevance 0
Apo A I and apo A II levels are significantly increased, while apo C III and apo B levels are reduced.48
Negative_regulation (reduced.48) of Gene_expression (levels) of apo B
3) Confidence 0.20 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922314 Disease Relevance 1.20 Pain Relevance 0
Trilipix with simvastatin 20 mg resulted in greater reductions in apo B protein levels compared with simvastatin 20 mg (P < 0.012).98
Negative_regulation (reductions) of Gene_expression (levels) of apo B
4) Confidence 0.20 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922314 Disease Relevance 0.47 Pain Relevance 0
In addition, fibrates have been shown to decrease cholesterol synthesis by inhibiting hydroxymethylglutamyl-coenzyme A reductase and to increase cholesterol excretion in the bile pool.55,60,61 Fenofibrate is able to reduce apo B levels, primarily as a result of reduced synthesis and secretion of TG, and not by directly influencing apo B production.45

Effects on nonlipid parameters

Negative_regulation (reduce) of Gene_expression (levels) of apo B in bile associated with bile
5) Confidence 0.20 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922314 Disease Relevance 0.82 Pain Relevance 0.08
In addition, these compounds reduce the levels of mutant p53.
Negative_regulation (reduce) of Gene_expression (levels) of mutant p53
6) Confidence 0.00 Published 1996 Journal Oncogene Section Abstract Doc Link 8632912 Disease Relevance 0.80 Pain Relevance 0.06

General Comments

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