INT6228

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Context Info
Confidence 0.78
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 0.46
Pain Relevance 6.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1a) signal transducer activity (Htr1a)
Anatomy Link Frequency
neuronal 1
medial 1
brain 1
soma 1
body 1
Htr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 50 99.82 Very High Very High Very High
noradrenaline 6 99.46 Very High Very High Very High
Serotonin 21 99.30 Very High Very High Very High
agonist 66 98.56 Very High Very High Very High
Desipramine 11 96.84 Very High Very High Very High
antidepressant 37 96.64 Very High Very High Very High
antagonist 14 96.32 Very High Very High Very High
Raphe 8 96.08 Very High Very High Very High
Clonidine 3 95.12 Very High Very High Very High
sNRI 2 95.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Body Weight 3 99.90 Very High Very High Very High
Affective Disorder 1 95.04 Very High Very High Very High
Nociception 1 64.32 Quite High
Depression 5 51.44 Quite High
Decapitation 1 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fluoxetine-induced changes in body weight and 5-HT1A receptor-mediated hormone secretion in rats on a tryptophan-deficient diet.
Localization (secretion) of 5-HT1A in body associated with body weight and fluoxetine
1) Confidence 0.78 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Title Doc Link 14604841 Disease Relevance 0.35 Pain Relevance 0.54
We have found that the distribution of 5-HT1A receptors in monkey brain, labelled with the agonist 3H-8-OH-DPAT and the antagonist 3H-WAY 100635 was very similar at the levels examined, and corresponded well with that observed for the cells containing mRNA coding for this receptor, confirming the somatodendritic localization of 5-HT1A receptors in monkey brain.
Localization (localization) of 5-HT1A in brain associated with antagonist and agonist
2) Confidence 0.78 Published 1996 Journal Histochem. J. Section Abstract Doc Link 8968727 Disease Relevance 0 Pain Relevance 0.26
These data suggest that hindlimb scratching induced by 5-HT agonists may not be centrally mediated but rather may be mediated by a neuronal 5-HT1A receptor localized outside the blood-brain barrier.
Localization (localized) of 5-HT1A in neuronal associated with agonist
3) Confidence 0.73 Published 1992 Journal Life Sci. Section Abstract Doc Link 1325017 Disease Relevance 0 Pain Relevance 0.33
Because 5-HT1A receptors located on the soma dendrites of serotonin (5-HT) neurons normally mediate an inhibition of 5-HT firing and release, the desensitization of these autoreceptors is essential for obtaining an enhancement of 5-HT transmission after treatment with 5-HT reuptake inhibitors (SSRIs).
Localization (located) of 5-HT1A in soma associated with ssri and serotonin
4) Confidence 0.73 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15190115 Disease Relevance 0 Pain Relevance 0.27
Repeated administration of milnacipran induces rapid desensitization of somatodendritic 5-HT1A autoreceptors but not postsynaptic 5-HT1A receptors.
Localization (desensitization) of 5-HT1A
5) Confidence 0.73 Published 2002 Journal J. Psychopharmacol. (Oxford) Section Title Doc Link 12236634 Disease Relevance 0 Pain Relevance 0.41
Repeated administration of milnacipran induces rapid desensitization of somatodendritic 5-HT1A autoreceptors but not postsynaptic 5-HT1A receptors.
Localization (desensitization) of 5-HT1A
6) Confidence 0.73 Published 2002 Journal J. Psychopharmacol. (Oxford) Section Title Doc Link 12236634 Disease Relevance 0 Pain Relevance 0.40
To further assess the desensitization of alpha2C-autoreceptors, alpha2A-heteroreceptors and 5-HT1A autoreceptors regulating the synthesis of dopa/NA or 5-HTP/5-HT after chronic desipramine and fluoxetine, the effects of clonidine (agonist at alpha2-auto/heteroreceptors) and 8-OH-DPAT (agonist at 5-HT1A-autoreceptors) were tested.
Localization (desensitization) of 5-HT1A associated with desipramine, agonist, clonidine and fluoxetine
7) Confidence 0.73 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10494882 Disease Relevance 0 Pain Relevance 1.34
In the present study, we investigated whether a link might exist between these effects, i.e., whether glucocorticoid receptor activation could be responsible for the fluoxetine-induced desensitization of 5-HT1A autoreceptors.
Localization (desensitization) of 5-HT1A associated with fluoxetine
8) Confidence 0.73 Published 1997 Journal Synapse Section Abstract Doc Link 9372553 Disease Relevance 0 Pain Relevance 0.60
Fluoxetine-induced desensitization of somatodendritic 5-HT1A autoreceptors is independent of glucocorticoid(s).
Localization (desensitization) of 5-HT1A associated with fluoxetine
9) Confidence 0.73 Published 1997 Journal Synapse Section Title Doc Link 9372553 Disease Relevance 0 Pain Relevance 0.53
In conclusion, the data demonstrate that 5-HT1A, 5-HT2, and 5-HT3 receptor subtypes are functionally present on NTS neurones receiving excitatory vagal afferent input.
Localization (present) of 5-HT1A
10) Confidence 0.73 Published 1997 Journal Neuropharmacology Section Abstract Doc Link 9225274 Disease Relevance 0 Pain Relevance 0.14
Long-term treatment with 5-HT-uptake inhibitors and noradrenaline-uptake inhibitor produces desensitization of 5-HT1A autoreceptors and alpha 2-heteroreceptors, respectively, which may be related therapeutically to the delayed onset of the effects of antidepressants.
Localization (desensitization) of 5-HT1A associated with antidepressant and noradrenaline
11) Confidence 0.73 Published 1996 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 8935715 Disease Relevance 0.05 Pain Relevance 0.41
Extracellular levels of serotonin (5-HT) and the regulation of 5-HT release by the 5-HT1A receptor were examined after single and repeated treatment with different types of antidepressant drugs: the selective 5-HT uptake inhibitor fluoxetine, the selective norepinephrine uptake inhibitor desipramine and the 5-HT2A/2C/alpha 2 receptor antagonist mianserin (each at 15.0 mg/kg).
Localization (release) of 5-HT1A associated with desipramine, norepinephrine uptake inhibitor, antidepressant, antagonist, serotonin and fluoxetine
12) Confidence 0.73 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7636750 Disease Relevance 0 Pain Relevance 0.52
One, the 5-HT1a receptor, releases a growth factor from astroglial cells.
Localization (releases) of 5-HT1a
13) Confidence 0.68 Published 1992 Journal Brain Res. Section Abstract Doc Link 1535269 Disease Relevance 0.06 Pain Relevance 0.32
It has also been reported that the firing activity of almost one-half of DRN 5-HT neurons can be reduced by stimulating some postsynaptic 5-HT1A receptors, localized within the medial prefrontal cortex (mPFC) and that trigger a negative “long-loop feedback” [17], [27].
Localization (localized) of 5-HT1A in medial
14) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821932 Disease Relevance 0 Pain Relevance 0.11

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