INT6229

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Context Info
Confidence 0.22
First Reported 1984
Last Reported 2005
Negated 2
Speculated 0
Reported most in Abstract
Documents 18
Total Number 19
Disease Relevance 2.21
Pain Relevance 6.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sult1b1) cytoplasm (Sult1b1)
Anatomy Link Frequency
median eminence 10
cerebral cortex 4
ganglion 4
hippocampus 3
brain 2
Sult1b1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
addiction 5 100.00 Very High Very High Very High
withdrawal 10 99.98 Very High Very High Very High
Dopamine 31 99.80 Very High Very High Very High
cerebral cortex 8 99.68 Very High Very High Very High
narcan 6 99.20 Very High Very High Very High
Hippocampus 2 98.88 Very High Very High Very High
Morphine 6 98.70 Very High Very High Very High
tetrodotoxin 14 98.64 Very High Very High Very High
Clonidine 9 98.46 Very High Very High Very High
noradrenaline 11 98.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 24 99.68 Very High Very High Very High
Decapitation 3 97.56 Very High Very High Very High
Opiate Addiction 2 78.08 Quite High
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Peripheral administration of L-3,4-dihydroxyphenylalanine (L-DOPA) methylester increased extracellular levels of DOPA and dopamine (DA) in the rat striatum monitored by in vivo brain microdialysis.
Positive_regulation (increased) of Gene_expression (levels) of DOPA in brain associated with dopamine
1) Confidence 0.22 Published 1992 Journal Life Sci. Section Abstract Doc Link 1325018 Disease Relevance 0 Pain Relevance 0.38
The Ca2+ channel blockers verapamil (100 microM) and Co2+ (4 mM) were effective in reducing the depolarization-induced DOPA synthesis.
Positive_regulation (induced) of Gene_expression (synthesis) of DOPA
2) Confidence 0.16 Published 1985 Journal Brain Res. Section Abstract Doc Link 2415215 Disease Relevance 0 Pain Relevance 0.23
Depolarizing agents such as K+ and veratridine increased the synthesis rate of DOPA in the median eminence in a dose-dependent manner with a maximal synthesis rate obtained at concentrations of 50 mM and 50 microM, respectively.
Positive_regulation (increased) of Gene_expression (synthesis) of DOPA in median eminence
3) Confidence 0.11 Published 1985 Journal Brain Res. Section Abstract Doc Link 2415215 Disease Relevance 0 Pain Relevance 0.18
A23187 (10 microM), a Ca2+ ionophore, stimulated basal DOPA synthesis in the median eminence.
Positive_regulation (stimulated) of Gene_expression (synthesis) of DOPA in median eminence
4) Confidence 0.11 Published 1985 Journal Brain Res. Section Abstract Doc Link 2415215 Disease Relevance 0 Pain Relevance 0.24
On the other hand, tetrodotoxin (2 microM), a Na+ channel blocker, did not change the basal and K+-induced DOPA synthesis in the median eminence whereas it completely inhibited the veratridine-induced DOPA synthesis.
Positive_regulation (induced) of Gene_expression (synthesis) of DOPA in median eminence associated with tetrodotoxin
5) Confidence 0.11 Published 1985 Journal Brain Res. Section Abstract Doc Link 2415215 Disease Relevance 0 Pain Relevance 0.24
On the other hand, tetrodotoxin (2 microM), a Na+ channel blocker, did not change the basal and K+-induced DOPA synthesis in the median eminence whereas it completely inhibited the veratridine-induced DOPA synthesis.
Neg (not) Positive_regulation (induced) of Gene_expression (synthesis) of DOPA in median eminence associated with tetrodotoxin
6) Confidence 0.11 Published 1985 Journal Brain Res. Section Abstract Doc Link 2415215 Disease Relevance 0 Pain Relevance 0.24
Removal of Ca2+ and addition of EGTA (1 mM) into the medium did not influence basal DOPA synthesis in the median eminence but blocked the K+- and veratridine-induced DOPA synthesis.
Positive_regulation (induced) of Gene_expression (synthesis) of DOPA in median eminence
7) Confidence 0.11 Published 1985 Journal Brain Res. Section Abstract Doc Link 2415215 Disease Relevance 0 Pain Relevance 0.22
After treatment with reserpine (5 mg/kg, s.c., 18 h before decapitation) and depletion of noradrenaline, clonidine (0.5 mg/kg) continued to decrease (50%-55%) but idazoxan (20 mg/kg) failed to increase the synthesis of DOPA, which suggested the involvement of an alpha-auto-receptor mechanism.
Neg (failed) Positive_regulation (increase) of Gene_expression (synthesis) of DOPA associated with noradrenaline, decapitation and clonidine
8) Confidence 0.08 Published 1992 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 1353254 Disease Relevance 0.10 Pain Relevance 0.55
Stimulation of DOPA synthesis in the superior cervical ganglion by veratridine.
Positive_regulation (Stimulation) of Gene_expression (synthesis) of DOPA in superior cervical ganglion associated with ganglion cysts
9) Confidence 0.07 Published 1984 Journal J. Neurochem. Section Title Doc Link 6141219 Disease Relevance 0.37 Pain Relevance 0.13
In the hypothalamus and cerebral cortex, clonidine (0.025-1 mg/kg, i.p.) decreased (18%-43%) and idazoxan (0.1-80 mg/kg, i.p.) increased (20%-73%) the synthesis of DOPA in a dose-dependent manner.
Positive_regulation (increased) of Gene_expression (synthesis) of DOPA in cerebral cortex associated with cerebral cortex and clonidine
10) Confidence 0.06 Published 1992 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 1353254 Disease Relevance 0.08 Pain Relevance 0.46
During the first week of coculture DOPA production gradually increased to reach a plateau after 7-9 days.
Positive_regulation (increased) of Gene_expression (production) of DOPA
11) Confidence 0.05 Published 1996 Journal Exp. Neurol. Section Abstract Doc Link 8635567 Disease Relevance 0 Pain Relevance 0.08
In morphine-dependent rats, naloxone (2 mg/kg, 2 h)-precipitated withdrawal increased the synthesis of DOPA in the cerebral cortex and hippocampus (50%).
Positive_regulation (increased) of Gene_expression (synthesis) of DOPA in hippocampus associated with narcan, hippocampus, cerebral cortex, withdrawal and morphine
12) Confidence 0.04 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16061219 Disease Relevance 0.08 Pain Relevance 0.88
Ionomycin, a calcium ionophore, stimulated DOPA synthesis to about the same extent as low-Na+ medium and also increased the incorporation of 32Pi into tyrosine hydroxylase. 8-Bromo cyclic AMP (1 mM) also stimulated DOPA production in the ganglion, and this stimulation was more than additive with that produced by low-Na+ medium.
Positive_regulation (stimulated) of Gene_expression (production) of DOPA in ganglion associated with ganglion cysts
13) Confidence 0.03 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 2857766 Disease Relevance 0.30 Pain Relevance 0.17
Ionomycin, a calcium ionophore, stimulated DOPA synthesis to about the same extent as low-Na+ medium and also increased the incorporation of 32Pi into tyrosine hydroxylase. 8-Bromo cyclic AMP (1 mM) also stimulated DOPA production in the ganglion, and this stimulation was more than additive with that produced by low-Na+ medium.
Positive_regulation (stimulated) of Gene_expression (synthesis) of DOPA in ganglion associated with ganglion cysts
14) Confidence 0.03 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 2857766 Disease Relevance 0.30 Pain Relevance 0.18
In the hypothalamus and cerebral cortex, clonidine (0.025-1 mg/kg, i.p.) decreased (18%-43%) and idazoxan (0.1-80 mg/kg, i.p.) increased (20%-73%) the synthesis of DOPA in a dose-dependent manner.
Positive_regulation (increased) of in hypothalamus Gene_expression (synthesis) of DOPA in cerebral cortex associated with cerebral cortex and clonidine
15) Confidence 0.02 Published 1992 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 1353254 Disease Relevance 0.08 Pain Relevance 0.46
Low-Na+ medium also increased the incorporation of 32Pi into tyrosine hydroxylase; the dependence of tyrosine hydroxylase phosphorylation on the Na+ concentration resembled that of DOPA synthesis.
Positive_regulation (increased) of Gene_expression (synthesis) of DOPA associated with addiction
16) Confidence 0.02 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 2857766 Disease Relevance 0.26 Pain Relevance 0.16
The stimulation of DOPA synthesis in low-Na+ medium was inhibited by methoxyverapamil, an inhibitor of Ca2+ uptake, and was partially blocked by tetrodotoxin, but it was not affected by the cholinergic antagonists hexamethonium and atropine.
Positive_regulation (stimulation) of Gene_expression (synthesis) of DOPA associated with tetrodotoxin and antagonist
17) Confidence 0.02 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 2857766 Disease Relevance 0.30 Pain Relevance 0.19
These data support the hypothesis that low-Na+ medium stimulates DOPA synthesis by raising intracellular Ca2+, which then promotes the phosphorylation of tyrosine hydroxylase.
Positive_regulation (stimulates) of Gene_expression (synthesis) of DOPA
18) Confidence 0.02 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 2857766 Disease Relevance 0.28 Pain Relevance 0.16
In morphine-dependent rats, naloxone (2 mg/kg, 2 h)-precipitated withdrawal increased the synthesis of DOPA in the cerebral cortex and hippocampus (50%).
Positive_regulation (increased) of in cerebral cortex Gene_expression (synthesis) of DOPA in hippocampus associated with narcan, hippocampus, cerebral cortex, withdrawal and morphine
19) Confidence 0.01 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16061219 Disease Relevance 0.08 Pain Relevance 0.88

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