INT62290

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Context Info
Confidence 0.28
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.14
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PTGES2) cytosol (PTGES2) mitochondrion (PTGES2)
Golgi apparatus (PTGES2) nucleus (PTGES2) DNA binding (PTGES2)
Anatomy Link Frequency
cartilage 2
extracellular matrix 2
PTGES2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 39 100.00 Very High Very High Very High
cytokine 14 99.98 Very High Very High Very High
aspirin 1 99.84 Very High Very High Very High
metalloproteinase 13 97.24 Very High Very High Very High
Osteoarthritis 45 96.52 Very High Very High Very High
cINOD 8 95.68 Very High Very High Very High
backache 2 90.16 High High
chemokine 11 85.04 High High
Arthritis 3 76.16 Quite High
Inflammatory stimuli 1 74.80 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 50 100.00 Very High Very High Very High
Stress 2 99.98 Very High Very High Very High
Osteoarthritis 49 96.52 Very High Very High Very High
Disease 11 90.96 High High
Arthritis 7 90.60 High High
Low Back Pain 2 90.16 High High
Osteophyte 1 89.64 High High
Adhesions 3 82.32 Quite High
Cancer 6 75.00 Quite High
Necrosis 4 70.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of mPGES-2 mRNA increased with term labour and PTL and expression of COX-2 and mPGES-1 mRNA with term labour, whereas cPGES expression did not change.
Positive_regulation (increased) of Gene_expression (Expression) of mPGES-2 mRNA
1) Confidence 0.28 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17105783 Disease Relevance 0.06 Pain Relevance 0.15
stimulate the production of prostaglandins, such as prostaglandin E2 (PGE2), whose roles in the inflammatory process and proteoglycan degradation in human OA cartilage have been reported [2].
Positive_regulation (stimulate) of Gene_expression (production) of prostaglandin E2 in cartilage associated with inflammation and osteoarthritis
2) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 1.10 Pain Relevance 0.57
Microarray analysis revealed that inflammatory stress increases expression of synthases and receptors for prostaglandin E2 (PGE(2)) and prostaglandin F2?
Positive_regulation (increases) of Gene_expression (expression) of prostaglandin E2 associated with stress and inflammation
3) Confidence 0.04 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 20839316 Disease Relevance 0.46 Pain Relevance 0.36
A cis-acting sequence closely related to the cyclic AMP response element has been shown to play a role in both basal and induced prostaglandin synthase 2 gene expression.
Positive_regulation (induced) of Gene_expression (expression) of prostaglandin synthase 2
4) Confidence 0.04 Published 1995 Journal Bioessays Section Abstract Doc Link 8634064 Disease Relevance 0.32 Pain Relevance 0.22
These cytokines induce the production of MMP-1, MMP-3 and inflammatory molecules such as prostaglandin E2 (PGE2), leading to the degradation of the extracellular matrix and the resorption of the mineral phase of the bone [1,2,3,4].
Positive_regulation (induce) of Gene_expression (production) of prostaglandin E2 in extracellular matrix associated with inflammation and cytokine
5) Confidence 0.01 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 1.20 Pain Relevance 0.58

General Comments

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