INT62291

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Context Info
Confidence 0.68
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 8.34
Pain Relevance 4.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PTGES2) cytosol (PTGES2) mitochondrion (PTGES2)
Golgi apparatus (PTGES2) nucleus (PTGES2) DNA binding (PTGES2)
Anatomy Link Frequency
PGE2 2
myometrium 1
muscle tissue 1
cartilage 1
nerve 1
PTGES2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 147 100.00 Very High Very High Very High
Nerve growth factor 3 100.00 Very High Very High Very High
aspirin 1 99.84 Very High Very High Very High
cytokine 44 99.76 Very High Very High Very High
metalloproteinase 26 99.64 Very High Very High Very High
substance P 1 99.48 Very High Very High Very High
Arthritis 7 98.76 Very High Very High Very High
chemokine 22 97.92 Very High Very High Very High
Osteoarthritis 90 96.52 Very High Very High Very High
Inflammatory response 11 96.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 179 100.00 Very High Very High Very High
Stress 14 99.78 Very High Very High Very High
Injury 8 99.06 Very High Very High Very High
Arthritis 15 98.76 Very High Very High Very High
Targeted Disruption 3 96.64 Very High Very High Very High
Osteoarthritis 98 96.52 Very High Very High Very High
Pain 8 94.20 High High
Disease 36 94.14 High High
Erythema 18 93.96 High High
Myositis 27 93.26 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In comparison, the expression of two other PGE synthases (PTGES2 and PTGES3) was unmodified.
Gene_expression (expression) of PTGES2
1) Confidence 0.68 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17928629 Disease Relevance 0.14 Pain Relevance 0.23
Recently, enhanced expression of COX-1 and COX-2 mRNA was demonstrated in inflamed muscle tissue from patients with myositis, suggesting a role for them in this disease.13 Three terminal PGE synthases (PGES) catalyse the formation of PGE2 from PGH2 Microsomal PGE synthase 1 (mPGES-1) is strongly induced by proinflammatory stimuli in various cells and preferentially couples with COX-2 contributing to significant PGE2 release.14–16 Cytosolic PGES (cPGES) and mPGES-2 are constitutively expressed and likely to function in the basal production of PGE217 18 Studies of mPGES-1 –/– knock-out mice have demonstrated a critical role for mPGES-1 in the development of pain, fever and inflammation.19 20 mPGES-1 is upregulated in a range of inflammatory diseases and considered a new target for therapeutic strategies to control induced PGE2 synthesis.21–23 However, the expression of mPGES-1 in muscle tissue from patients with myositis has not been studied.
Gene_expression (expressed) of mPGES-2 in muscle tissue associated with targeted disruption, pain, inflammation, fever, disease and myositis
2) Confidence 0.58 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2582339 Disease Relevance 1.35 Pain Relevance 0.34
Prostaglandin E(2) (PGE(2)) is synthesized by one of three enzymes, cytosolic prostaglandin E synthase (cPGES), microsomal PGES-1 (mPGES-1) and microsomal PGES-2 (mPGES-2).
Gene_expression (synthesized) of mPGES-2
3) Confidence 0.41 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17105783 Disease Relevance 0.09 Pain Relevance 0.22
We show mPGES-1 protein located predominantly in myometrial and vascular smooth muscle cells (SMCs), whilst mPGES-2 protein is largely in stromal cells surrounding the SMC and cPGES is diffusely located throughout the myometrium.
Gene_expression (is) of mPGES-2 protein in myometrium
4) Confidence 0.41 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17105783 Disease Relevance 0.06 Pain Relevance 0.16
Expression of mPGES-2 mRNA increased with term labour and PTL and expression of COX-2 and mPGES-1 mRNA with term labour, whereas cPGES expression did not change.
Gene_expression (Expression) of mPGES-2 mRNA
5) Confidence 0.37 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17105783 Disease Relevance 0.06 Pain Relevance 0.15
In contrast, the expression of the isoenzymes microsomal prostaglandin E synthase-2 (mPGES-2) and cytosolic prostaglandin E synthase (cPGES) was unaffected by TNF?
Gene_expression (expression) of microsomal prostaglandin E synthase-2
6) Confidence 0.23 Published 2010 Journal BMC Genomics Section Abstract Doc Link PMC2873473 Disease Relevance 0.44 Pain Relevance 0.13
Cyclooxygenase (COX) and prostaglandin E2 synthase (PGES) are key enzymes for PGE2 biosynthesis under inflammatory conditions.
Gene_expression (synthase) of prostaglandin E2 in PGE2 associated with inflammation
7) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 1.21 Pain Relevance 0.66
stimulate the production of prostaglandins, such as prostaglandin E2 (PGE2), whose roles in the inflammatory process and proteoglycan degradation in human OA cartilage have been reported [2].
Gene_expression (production) of prostaglandin E2 in cartilage associated with inflammation and osteoarthritis
8) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 1.10 Pain Relevance 0.57
Microarray analysis revealed that inflammatory stress increases expression of synthases and receptors for prostaglandin E2 (PGE(2)) and prostaglandin F2?
Gene_expression (expression) of prostaglandin E2 associated with stress and inflammation
9) Confidence 0.06 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 20839316 Disease Relevance 0.46 Pain Relevance 0.36
Prostaglandin-E2 is produced by adult human epidermal melanocytes in response to UVB in a melanogenesis-independent manner

Excessive ultraviolet radiation (UVR) exposure induces erythema, mediated in part by prostaglandin-E2 (PGE2).

Gene_expression (produced) of Prostaglandin-E2 in PGE2 associated with erythema
10) Confidence 0.04 Published 2010 Journal Pigment Cell & Melanoma Research Section Title Doc Link PMC2881306 Disease Relevance 0.18 Pain Relevance 0.07
A cis-acting sequence closely related to the cyclic AMP response element has been shown to play a role in both basal and induced prostaglandin synthase 2 gene expression.
Gene_expression (expression) of prostaglandin synthase 2
11) Confidence 0.04 Published 1995 Journal Bioessays Section Abstract Doc Link 8634064 Disease Relevance 0.32 Pain Relevance 0.22
Primary EM cultures from all 10 donors expressed cPLA2, COX-1, cPGES, mPGES-1 and mPGES-2 proteins (Figure 2A).
Gene_expression (expressed) of mPGES-2
12) Confidence 0.03 Published 2010 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2881306 Disease Relevance 0 Pain Relevance 0.03
Incubation with hTWEAK increased the production of prostaglandin E2, matrix metalloproteinase-1 (MMP-1), IL-6, and the chemokines IL-8, RANTES (regulated on activation, normal T expressed and secreted) and interferon-?
Gene_expression (production) of prostaglandin E2 associated with chemokine and metalloproteinase
13) Confidence 0.01 Published 2002 Journal Arthritis Res Section Abstract Doc Link PMC83846 Disease Relevance 0.42 Pain Relevance 0.17
These cytokines induce the production of MMP-1, MMP-3 and inflammatory molecules such as prostaglandin E2 (PGE2), leading to the degradation of the extracellular matrix and the resorption of the mineral phase of the bone [1,2,3,4].
Gene_expression (production) of prostaglandin E2 in extracellular matrix associated with inflammation and cytokine
14) Confidence 0.01 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 1.19 Pain Relevance 0.58
In wound exudate, 19 out of 20 mediators were reliably detected including IL-1 beta, IL-2, IL-4, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17, TNFalpha, INF gamma, G-CSF, GM-CSF, MCP-1 and MIP-1 beta, nerve growth factor (NGF), prostaglandin E2 (PG-E2) and substance P.
Gene_expression (detected) of prostaglandin E2 in nerve associated with nerve growth factor, injury and substance p
15) Confidence 0.00 Published 2008 Journal Journal of visualized experiments : JoVE Section Abstract Doc Link 19078937 Disease Relevance 1.32 Pain Relevance 0.86

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