INT62293

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Context Info
Confidence 0.06
First Reported 1995
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.05
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PTGES2) cytosol (PTGES2) mitochondrion (PTGES2)
Golgi apparatus (PTGES2) nucleus (PTGES2) DNA binding (PTGES2)
Anatomy Link Frequency
MDA-MB-231 1
PTGES2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 1 97.56 Very High Very High Very High
metalloproteinase 22 92.88 High High
cINOD 3 87.24 High High
aspirin 1 84.52 Quite High
Inflammation 5 75.00 Quite High
COX-2 inhibitor 12 32.24 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 3 97.24 Very High Very High Very High
Cancer 91 90.84 High High
Apoptosis 14 79.84 Quite High
Melanoma 10 76.96 Quite High
Death 6 76.36 Quite High
Reprotox - General 1 52 50.00 Quite Low
Adenocarcinoma 2 38.40 Quite Low
Repression 2 16.36 Low Low
Inflammatory Breast Neoplasms 16 5.00 Very Low Very Low Very Low
Metastasis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with a significant decrease in PGE2 secretion by MDA-MB-231 cells after celecoxib treatment [15], we observed a twofold decrease in prostaglandin E synthase 2 (Figure 4), which is the enzyme involved in the synthesis of PGE2.
Negative_regulation (decrease) of E synthase 2 in MDA-MB-231
1) Confidence 0.06 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.42 Pain Relevance 0.12
Finally, in the COX pathway, celecoxib treatment caused downregulation of phospholipase A2 receptor 1 and prostaglandin E synthase 2, which is consistent with our previous report in which PGE2 protein was shown to be significantly downregulated after celecoxib treatment [15,29].
Negative_regulation (downregulation) of E synthase 2
2) Confidence 0.06 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.30 Pain Relevance 0
Use of prostaglandin synthase 2 specific inhibitors and antisense oligonucleotides has led to the suggestion that specific ligands activate alternative pathways of prostanoid production, using one of the prostaglandin synthase isoforms preferentially.
Negative_regulation (inhibitors) of prostaglandin synthase 2
3) Confidence 0.02 Published 1995 Journal Bioessays Section Abstract Doc Link 8634064 Disease Relevance 0.33 Pain Relevance 0.22

General Comments

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