INT6230

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Context Info
Confidence 0.79
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 40
Total Number 40
Disease Relevance 13.11
Pain Relevance 20.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Ddc) intracellular (Ddc) cellular amino acid metabolic process (Ddc)
cytoplasm (Ddc)
Anatomy Link Frequency
RVLM 6
nerve 5
neuronal 4
nucleus accumbens 4
nucleus 3
Ddc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 80 100.00 Very High Very High Very High
Dopamine 61 100.00 Very High Very High Very High
Neurotransmitter 52 100.00 Very High Very High Very High
antagonist 29 100.00 Very High Very High Very High
Glutamate 46 99.96 Very High Very High Very High
Eae 30 99.90 Very High Very High Very High
medulla 84 99.84 Very High Very High Very High
Rostral ventrolateral medulla 86 99.76 Very High Very High Very High
Nucleus accumbens 30 99.76 Very High Very High Very High
Nicotine 36 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 37 99.52 Very High Very High Very High
Sprains And Strains 26 99.36 Very High Very High Very High
Hypertension 101 98.96 Very High Very High Very High
Hepatitis 18 98.96 Very High Very High Very High
Autoimmune Hepatitis 169 98.84 Very High Very High Very High
Hypopigmentation 2 98.52 Very High Very High Very High
Disease 61 98.04 Very High Very High Very High
Ganglion Cysts 19 97.20 Very High Very High Very High
Stress 12 97.16 Very High Very High Very High
Dyskinesias 3 96.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Injection of nicotine (30 micrograms) into the ventral tegmental area increased locomotor activity and L-DOPA release from the nucleus accumbens.
Localization (release) of L-DOPA in nucleus accumbens associated with nucleus accumbens, ventral tegmentum, eae and nicotine
1) Confidence 0.79 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8874145 Disease Relevance 0 Pain Relevance 0.92
Ventral tegmental injection of nicotine induces locomotor activity and L-DOPA release from nucleus accumbens.
Localization (release) of L-DOPA in nucleus accumbens associated with nucleus accumbens, eae and nicotine
2) Confidence 0.79 Published 1996 Journal Eur. J. Pharmacol. Section Title Doc Link 8874145 Disease Relevance 0 Pain Relevance 0.88
Systemic nicotine (1 mg/kg s.c.) increased locomotor activity and L-DOPA release preferentially in the nucleus accumbens as compared with the striatum.
Localization (release) of L-DOPA in nucleus accumbens associated with nucleus accumbens, eae and nicotine
3) Confidence 0.79 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8874145 Disease Relevance 0 Pain Relevance 0.88
Nicotine induces locomotor activity and L-DOPA release from the nucleus accumbens via nicotinic receptors in the ventral tegmental area.
Localization (release) of L-DOPA in ventral associated with ventral tegmentum, nucleus accumbens, eae and nicotine
4) Confidence 0.79 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8874145 Disease Relevance 0 Pain Relevance 0.91
By microdialysis of left RVLM area, the basal L-DOPA release was higher in SHR than in Wistar-Kyoto (WKY) rats.
Localization (release) of L-DOPA in RVLM associated with rostral ventrolateral medulla
5) Confidence 0.70 Published 1995 Journal Clin Exp Pharmacol Physiol Suppl Section Abstract Doc Link 9072438 Disease Relevance 0.56 Pain Relevance 0.46
On the other hand, in the left rostral ventrolateral medulla, the basal L-DOPA release was higher in spontaneously hypertensive rats than that in Wistar-Kyoto rats.
Localization (release) of L-DOPA in medulla associated with rostral ventrolateral medulla and hypertension
6) Confidence 0.70 Published 1995 Journal Neuroscience Section Abstract Doc Link 7477914 Disease Relevance 1.13 Pain Relevance 0.31
Intensive electrical stimulation of the ipsilateral posterior hypothalamic nucleus (50 Hz, 0.3 mA, 0.1 ms duration, twice for 5 min at an interval of 5 min) selectively caused the release of L-DOPA in a repetitive and constant manner.
Localization (release) of L-DOPA in hypothalamic nucleus
7) Confidence 0.70 Published 1999 Journal Neuroscience Section Abstract Doc Link 10392836 Disease Relevance 0.35 Pain Relevance 0.73
Tetrodotoxin suppressed the release of L-DOPA, but partially inhibited hypertension with only a slight inhibition of tachycardia evoked by stimulation of the posterior hypothalamic nucleus.
Localization (release) of L-DOPA in hypothalamic nucleus associated with tetrodotoxin, heart rate under development and hypertension
8) Confidence 0.70 Published 1999 Journal Neuroscience Section Abstract Doc Link 10392836 Disease Relevance 0.49 Pain Relevance 0.73
The basal L-DOPA release was Ca2(+)-dependent and tetrodotoxin-sensitive.
Localization (release) of L-DOPA associated with tetrodotoxin
9) Confidence 0.69 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8874145 Disease Relevance 0 Pain Relevance 0.80
By microdialysis in CVLM, basal L-DOPA release was constantly detectable and was lower in SHR than that in WKY.
Localization (release) of L-DOPA in CVLM associated with medulla
10) Confidence 0.69 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 8570091 Disease Relevance 0.24 Pain Relevance 0.46
Forty to 100 mM K+ concentration-dependently released L-DOPA.
Localization (released) of L-DOPA
11) Confidence 0.68 Published 1994 Journal Neuroscience Section Abstract Doc Link 7816196 Disease Relevance 0.14 Pain Relevance 0.32
Enhanced presynaptic neuronal L-DOPA release, including a decrease in decarboxylation and sensitization of postsynaptic pressor sites to L-DOPA in RVLM, may be involved in the maintenance of hypertension in SHR.
Localization (release) of L-DOPA in neuronal associated with rostral ventrolateral medulla and hypertension
12) Confidence 0.61 Published 1995 Journal Clin Exp Pharmacol Physiol Suppl Section Abstract Doc Link 9072438 Disease Relevance 0.64 Pain Relevance 0.46
TTX-sensitive L-DOPA release was higher in SHR than in WKY. 3.
Localization (release) of L-DOPA
13) Confidence 0.61 Published 1995 Journal Clin Exp Pharmacol Physiol Suppl Section Abstract Doc Link 9072438 Disease Relevance 0.60 Pain Relevance 0.48
Tonic neuronal L-DOPA release is impaired in this nucleus of spontaneously hypertensive rats.
Localization (release) of L-DOPA in nucleus associated with hypertension
14) Confidence 0.61 Published 1995 Journal Neuroscience Section Abstract Doc Link 7477914 Disease Relevance 0.71 Pain Relevance 0.32
By microdialysis in the left nucleus tractus solitarii area, the basal L-DOPA release was lower in spontaneously hypertensive rats than that in Wistar-Kyoto rats.
Localization (release) of L-DOPA in nucleus associated with hypertension
15) Confidence 0.61 Published 1995 Journal Neuroscience Section Abstract Doc Link 7477914 Disease Relevance 0.50 Pain Relevance 0.32
Tonic neuronal L-DOPA release is enhanced in spontaneously hypertensive rats.
Localization (release) of L-DOPA in neuronal associated with hypertension
16) Confidence 0.61 Published 1995 Journal Neuroscience Section Abstract Doc Link 7477914 Disease Relevance 1.15 Pain Relevance 0.28
Effects of nicotine systemically or locally on locomotor activity and L-3,4-dihydroxyphenylalanine (L-DOPA) release were studied using microdialysis in the nucleus accumbens of freely moving rats.
Localization (release) of L-DOPA in nucleus accumbens associated with nucleus accumbens, eae and nicotine
17) Confidence 0.61 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8874145 Disease Relevance 0 Pain Relevance 0.72
Tonic neuronal activity to release L-DOPA is lost in the CVLM of adult SHR and this loss may contribute to maintenance of hypertension in SHR.
Localization (release) of L-DOPA in neuronal associated with medulla and hypertension
18) Confidence 0.60 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 8570091 Disease Relevance 0.33 Pain Relevance 0.49
Loss of tonic neuronal activity to release L-DOPA in the caudal ventrolateral medulla of spontaneously hypertensive rats.
Localization (release) of L-DOPA in medulla associated with medulla and hypertension
19) Confidence 0.60 Published 1995 Journal Neurosci. Lett. Section Title Doc Link 8570091 Disease Relevance 0.26 Pain Relevance 0.49
Ca2+ deprivation and tetrodotoxin decreased L-DOPA (300 microM)-induced release of Glu.
Localization (release) of L-DOPA associated with tetrodotoxin and glutamate
20) Confidence 0.60 Published 1993 Journal Brain Res. Section Abstract Doc Link 8104083 Disease Relevance 0 Pain Relevance 0.53

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