INT62301

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Context Info
Confidence 0.19
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 3.20
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EIF4E2) translation factor activity, nucleic acid binding (EIF4E2) translation (EIF4E2)
cytoplasm (EIF4E2)
Anatomy Link Frequency
blood 1
juvenile 1
EIF4E2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 99.00 Very High Very High Very High
Arthritis 5 97.00 Very High Very High Very High
rheumatoid arthritis 4 95.40 Very High Very High Very High
spinal inflammation 1 92.04 High High
depression 30 67.80 Quite High
Pain 40 67.04 Quite High
Disease Link Frequency Relevance Heat
Scotoma 90 99.96 Very High Very High Very High
INFLAMMATION 2 99.00 Very High Very High Very High
Retina Disease 65 98.64 Very High Very High Very High
Autoimmune Disease 1 97.80 Very High Very High Very High
Arthritis 3 97.00 Very High Very High Very High
Infection 1 95.92 Very High Very High Very High
Rheumatoid Arthritis 4 95.40 Very High Very High Very High
Seronegative Spondarthritis 2 94.16 High High
Low Back Pain 1 92.04 High High
Mental Disorders 60 70.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of the superantigens staphylococcal enterotoxin A, staphylococcal enterotoxin B, and streptococcal M type 5 protein on T cells derived from inflammatory tissues and peripheral blood (PB) of arthritis patients was studied in seven rheumatoid arthritis (RA), two psoriatic arthritis, two reactive arthritis, and one ankylosing spondylitis patient.
Regulation (effect) of streptococcal M type 5 protein in blood associated with seronegative spondarthritis, spinal inflammation, inflammation, rheumatoid arthritis and arthritis
1) Confidence 0.19 Published 1996 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 8635287 Disease Relevance 1.13 Pain Relevance 0.49
Spearman’s rank correlation analyses were used to assess the associations between the objective visual functional results (WVA, WLCVA, binocular near vision, the merged areas of binocular V:4e target and II-4-e target, as well as the merged central scotoma area to the II:4e target), and the subscale responses from the VFQ-25 questionnaires.
Regulation (target) of II-4-e associated with scotoma
2) Confidence 0.03 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2850827 Disease Relevance 0.15 Pain Relevance 0
Similarly, there was no difference in adjusted responses for patients with or without a centrally extensive scotoma (II-4-e target).
Regulation (target) of II-4-e associated with scotoma
3) Confidence 0.02 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2850827 Disease Relevance 0.38 Pain Relevance 0.03
These findings are in concordance with a study assessing everyday activities in patients with central retinal degeneration, and juvenile macular dystrophies.19 This study found highly significant correlations between activities involving central vision such as reading and the objective measures of central vision, ie, VA, and the area of central scotoma (II-4-e target).
Regulation (target) of II-4-e in juvenile associated with scotoma and retina disease
4) Confidence 0.02 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2850827 Disease Relevance 0.67 Pain Relevance 0.06
The merged VF areas of binocular V-4-e target and the merged areas of the central scotoma (II-4-e target) also showed significant correlations with the questionnaire responses but there were fewer significant correlations and they were of lower magnitude.
Regulation (target) of II-4-e associated with scotoma
5) Confidence 0.02 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2850827 Disease Relevance 0.51 Pain Relevance 0.13
For binocular near VA the cut-off point was “able to read text” and “not able to read text”; for the merged areas of the binocular (V-4e target) the cut-off point was VF area of “>200 cm2” and the VF area of “<200 cm2”; and finally for the merged central scotoma area (II-4-e target) the patients were grouped into “no or small (<20 cm2) centrally situated scotoma” (within 40°) of VF or “large/not measurable (>20 cm2) centrally situated scotoma of the VF (within 40°).
Regulation (target) of II-4-e associated with scotoma
6) Confidence 0.02 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2850827 Disease Relevance 0.36 Pain Relevance 0

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