INT62331

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Context Info
Confidence 0.72
First Reported 1996
Last Reported 2011
Negated 6
Speculated 2
Reported most in Body
Documents 26
Total Number 28
Disease Relevance 17.75
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFRSF8) plasma membrane (TNFRSF8) cytoplasm (TNFRSF8)
Anatomy Link Frequency
T-cell 4
HeLa 2
plasma 1
lymphocytes 1
B cell 1
TNFRSF8 (Homo sapiens)
Pain Link Frequency Relevance Heat
member 8 31 99.96 Very High Very High Very High
agonist 14 99.82 Very High Very High Very High
Inflammation 112 99.74 Very High Very High Very High
Inflammatory response 14 98.96 Very High Very High Very High
rheumatoid arthritis 15 93.04 High High
Central nervous system 14 92.24 High High
Pain 4 92.20 High High
imagery 9 88.88 High High
cytokine 44 87.72 High High
abdominal pain 9 87.36 High High
Disease Link Frequency Relevance Heat
Hodgkin's Disease 154 99.98 Very High Very High Very High
Anaplastic Large Cell Lymphoma 45 99.96 Very High Very High Very High
Malignant Neoplastic Disease 22 99.76 Very High Very High Very High
INFLAMMATION 126 99.74 Very High Very High Very High
Disease 113 99.56 Very High Very High Very High
Viral Infection 42 99.44 Very High Very High Very High
Lymphatic System Cancer 243 99.04 Very High Very High Very High
Leukemia 30 99.04 Very High Very High Very High
Cancer 86 98.80 Very High Very High Very High
Epstein-barr Virus 61 96.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To scrutinize the specificity of the observed interaction, we asked if the preference of Trx1 for CD30 might be caused by an unusual density of disulfide bonds within CD30 and/or exceptional cell surface expression levels.
Neg (exceptional) Gene_expression (expression) of CD30
1) Confidence 0.72 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.06 Pain Relevance 0.08
Under inflammatory conditions, CD30 expression is markedly induced.
Gene_expression (expression) of CD30 associated with inflammation
2) Confidence 0.72 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.85 Pain Relevance 0.12
While mock-transfected HeLa cells did not capture Trx1(CSAAA) on their surface (Figure 4C, lower row), expression of CD30 led to a strong Trx1 surface association and colocalization of both proteins (Figure 4C, upper row).
Gene_expression (expression) of CD30 in HeLa
3) Confidence 0.72 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0 Pain Relevance 0
Both Trx1 secretion and CD30 expression have been associated with virally transformed lymphocytes.
Gene_expression (expression) of CD30 in lymphocytes
4) Confidence 0.72 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 1.12 Pain Relevance 0.21
Similar results were obtained when another monoclonal antibody against CD30, MAB229 (R&D Systems; Clone 81337), was used to examine CD30 expression (Figure 5A, middle panel).
Spec (examine) Gene_expression (expression) of CD30
5) Confidence 0.72 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.12 Pain Relevance 0
To further exclude that Trx1 reactivity of receptors is determined or limited by surface expression levels, we ectopically overexpressed CD30 or other TNFR superfamily members under control of the same promoter in HeLa cells and analyzed Trx1 cell surface trapping by indirect immunofluorescence.
Spec (analyzed) Gene_expression (overexpressed) of CD30 in HeLa
6) Confidence 0.72 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0 Pain Relevance 0
As shown in Figure 4E, murine CD30 expressed on the Rauscher murine leukemia virus-induced T-cell lymphoma line RMA is efficiently targeted by Trx1(CSAAA), thus demonstrating that the additional CRDs in human CD30 are not required for Trx1 reactivity.
Gene_expression (expressed) of CD30 in T-cell associated with leukemia and lymphatic system cancer
7) Confidence 0.72 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.20 Pain Relevance 0
In vivo, cell surface expression of CD30 appears to be tightly regulated and restricted to B and T lymphocytes undergoing activation in lymphoid tissues.
Gene_expression (expression) of CD30 in lymphoid tissues
8) Confidence 0.72 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.60 Pain Relevance 0.07
Immunoblotting and flow cytometry experiments confirmed that BL-41 cells, unlike the other lymphocytic cell lines, do not express CD30 (Supplementary Figure S2), thus explaining the absence of the 160 kDa conjugate band (Figure 2B).


Neg (not) Gene_expression (express) of CD30 in band
9) Confidence 0.72 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0 Pain Relevance 0
While Hodgkin's disease cell lines typically express high levels of CD30, other cell lines including LCL-721.220 or CCRF-CEM show at least 20- to 100-fold lower expression as determined by flow cytometry, yet the same selective targeting was observed.
Gene_expression (express) of CD30 in CCRF-CEM associated with disease
10) Confidence 0.72 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.10 Pain Relevance 0.05
Subsequent analysis of CD30 cell surface expression by flow cytometry and fluorescence microscopy revealed that a brief treatment of CD30+ cells with wild-type Trx1 led to the complete loss of CD30 recognition by the Ki-1 antibody (Figure 5A, upper panel and Figure 5B, second column).
Gene_expression (expression) of CD30 in upper
11) Confidence 0.72 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.15 Pain Relevance 0
Immunocytochemistry revealed these anaplastic cells to be cytokeratin and placenta-like alkaline phosphatase positive but S100, CD30 and lymphoid marker negative.
Neg (negative) Gene_expression (positive) of CD30 in placenta
12) Confidence 0.71 Published 2000 Journal Ann. Oncol. Section Abstract Doc Link 10942066 Disease Relevance 0.71 Pain Relevance 0.08
An autopsy of the pancreas revealed clusters of large, atypical cells, which morphologically and immunophenotypically were consistent with CD30 positive, ALK-negative anaplastic large cell lymphoma (ALCL) of T-cell lineage and multifocal fat necrosis (panniculitis) in the peripancreatic adipose tissue.
Gene_expression (positive) of CD30 in T-cell associated with fat necrosis, obesity, anaplastic large cell lymphoma and panniculitis
13) Confidence 0.66 Published 2006 Journal Haematologica Section Abstract Doc Link 17194661 Disease Relevance 1.15 Pain Relevance 0.09
[CD30-positive anaplastic large cell lymphoma of bone treated with autologous peripheral blood stem cell transplantation].
Gene_expression (positive) of CD30 in stem cell associated with anaplastic large cell lymphoma
14) Confidence 0.65 Published 1999 Journal Rinsho Ketsueki Section Title Doc Link 10658478 Disease Relevance 0.36 Pain Relevance 0.14
Trx1-mediated reducing activity interrupts agonist-induced CD30 signaling in YT cells
Gene_expression (signaling) of CD30 associated with agonist
15) Confidence 0.62 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.22 Pain Relevance 0.05
Elevated levels of sCD30 occur during viral infection.
Gene_expression (levels) of sCD30 associated with viral infection
16) Confidence 0.62 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 1.11 Pain Relevance 0.21
In contrast, expression of CD95 (Figure 4D), TNFR1 or NGFR (data not shown) did not promote Trx1 interactions with the cell surface, further strengthening the notion that Trx1 reactivity is a specific property of CD30.
Gene_expression (property) of CD30
17) Confidence 0.62 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.12 Pain Relevance 0
As found in the majority of cases, Reed-Stenberg cells with positive expressions of CD30 and/or CD15, and negative expressions of CD20, CD3 and CD4, corroborate the diagnosis (Table 2).
Gene_expression (expressions) of CD30
18) Confidence 0.62 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2886079 Disease Relevance 1.11 Pain Relevance 0
His nasopharyngeal biopsy together with immunohistochemistry analysis showed negative expressions of CD15, CD20 and CD3, but positive expressions of CD30 and epithelial membrane antigen.
Gene_expression (expressions) of CD30
19) Confidence 0.48 Published 2010 Journal J Med Case Reports Section Abstract Doc Link PMC2886079 Disease Relevance 0.57 Pain Relevance 0
Large, frequently intrasinusoidal tumor cells expressed CD138, EMA, weakly IgA and kappa, but were negative for other B-cell markers, T-cell markers and CD30.
Neg (negative) Gene_expression (negative) of CD30 in T-cell associated with cancer
20) Confidence 0.41 Published 2005 Journal Pol J Pathol Section Abstract Doc Link 15921012 Disease Relevance 1.14 Pain Relevance 0.07

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