INT62336

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Context Info
Confidence 0.70
First Reported 1995
Last Reported 2008
Negated 3
Speculated 2
Reported most in Abstract
Documents 38
Total Number 46
Disease Relevance 14.45
Pain Relevance 5.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hdc) lyase activity (Hdc) cellular amino acid metabolic process (Hdc)
Anatomy Link Frequency
ear skin 5
stomach 4
gingiva 3
dental pulp 3
liver 2
Hdc (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 457 99.98 Very High Very High Very High
cytokine 92 99.98 Very High Very High Very High
Hyperalgesia 2 99.80 Very High Very High Very High
Antinociceptive 1 99.48 Very High Very High Very High
bradykinin 8 99.40 Very High Very High Very High
Pain 23 98.66 Very High Very High Very High
dexamethasone 10 97.48 Very High Very High Very High
cerebral cortex 12 96.68 Very High Very High Very High
antagonist 10 94.56 High High
aspirin 5 94.48 High High
Disease Link Frequency Relevance Heat
Crystal Associated Disease 496 100.00 Very High Very High Very High
INFLAMMATION 465 99.84 Very High Very High Very High
Stress 41 99.80 Very High Very High Very High
Hyperalgesia 2 99.80 Very High Very High Very High
Disease 60 99.74 Very High Very High Very High
Necrosis 29 98.82 Very High Very High Very High
Pain 23 98.66 Very High Very High Very High
Cancer 35 98.64 Very High Very High Very High
Aging 4 96.24 Very High Very High Very High
Arthropathy 8 96.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since mast cells are known to produce histamine through a difference mechanism than HDC induction, we compared LPS-induced HDC activity in dental pulp and gingiva to that in ear skin (a tissue rich in mast cells) and liver (a tissues lacking in mast cells).
Positive_regulation (induced) of HDC in ear skin
1) Confidence 0.70 Published 2006 Journal Arch. Oral Biol. Section Abstract Doc Link 16769033 Disease Relevance 0.14 Pain Relevance 0.03
Still, the relative increase in LPS-induced HDC activity in dental pulp and gingiva were much greater than that in ear skin.
Positive_regulation (increase) of HDC in ear skin
2) Confidence 0.70 Published 2006 Journal Arch. Oral Biol. Section Abstract Doc Link 16769033 Disease Relevance 0.23 Pain Relevance 0.06
Following 3-day treatment of RCS, which is the essential period for the induction of hyperalgesia in mice, HDC mRNA level and enzyme activity increased in the stomach.
Positive_regulation (increased) of HDC in stomach associated with stress and hyperalgesia
3) Confidence 0.70 Published 1995 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 8750791 Disease Relevance 0.89 Pain Relevance 0.10
Administration of these drugs, orally or intraperitoneally, elevated histidine decarboxylase activity in the stomach but not in the liver, lung or spleen, dexamethasone being the most potent.
Neg (not) Positive_regulation (elevated) of histidine decarboxylase in lung associated with dexamethasone
4) Confidence 0.68 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12535861 Disease Relevance 0.22 Pain Relevance 0.23
These results and our previously reported findings (elevation of histidine decarboxylase activity by lipopolysaccharide, interleukin-1 and tumour necrosis factor, and by different types of stress) suggest that an elevation of histidine decarboxylase activity in the stomach may be a common feature of the responses to ulcerogenic stimuli.
Positive_regulation (elevation) of histidine decarboxylase in stomach associated with stress, necrosis and cancer
5) Confidence 0.68 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12535861 Disease Relevance 0.30 Pain Relevance 0.25
The histamine newly formed via the induction of HDC is released immediately and may be involved in a variety of immune responses.
Positive_regulation (induction) of HDC
6) Confidence 0.67 Published 2001 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 11496827 Disease Relevance 0.43 Pain Relevance 0.24
However, the histamine-forming enzyme, histidine decarboxylase (HDC), is induced in a variety of tissues in response (i) to gram-positive and gram-negative bacterial components (lipopolysaccharides, peptidoglycan, and enterotoxin A) and (ii) to various cytokines (IL-1, IL-3, IL-12, IL-18, TNF, G-CSF, and GM-CSF).
Positive_regulation (induced) of histidine decarboxylase associated with cytokine
7) Confidence 0.67 Published 2001 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 11496827 Disease Relevance 0.17 Pain Relevance 0.13
[Induction of histidine decarboxylase in inflammation and immune responses].
Positive_regulation (Induction) of histidine decarboxylase associated with inflammation and cytokine
8) Confidence 0.67 Published 2001 Journal Nippon Yakurigaku Zasshi Section Title Doc Link 11496827 Disease Relevance 0.46 Pain Relevance 0.35
Reviewing our work and that of Schayer and Kahlson, the pioneers in this field, lead us to the conclusion that nowadays we need to understand that histamine can be produced via the induction of HDC by a mechanism coupled with the cytokine network.
Positive_regulation (induction) of HDC associated with cytokine
9) Confidence 0.67 Published 2001 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 11496827 Disease Relevance 0.87 Pain Relevance 0.34
However, the histamine-forming enzyme, histidine decarboxylase (HDC), is induced in a variety of tissues in response (i) to gram-positive and gram-negative bacterial components (lipopolysaccharides, peptidoglycan, and enterotoxin A) and (ii) to various cytokines (IL-1, IL-3, IL-12, IL-18, TNF, G-CSF, and GM-CSF).
Positive_regulation (induced) of HDC associated with cytokine
10) Confidence 0.67 Published 2001 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 11496827 Disease Relevance 0.17 Pain Relevance 0.13
LPS also induced a marked increase in the HDC activity in liver and ear skin at 6 h after LPS injection.
Positive_regulation (increase) of HDC in ear skin
11) Confidence 0.61 Published 2006 Journal Arch. Oral Biol. Section Abstract Doc Link 16769033 Disease Relevance 0.12 Pain Relevance 0.03
HDC is induced even in mast-cell-deficient mice.
Positive_regulation (induced) of HDC
12) Confidence 0.58 Published 2001 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 11496827 Disease Relevance 0.21 Pain Relevance 0.19
IL-6, Irg1, PROK-2, Hdc and PUMA-g mRNA upregulation in MSU-stimulated mouse peritoneal macrophages
Positive_regulation (upregulation) of Hdc in peritoneal macrophages associated with crystal associated disease
13) Confidence 0.52 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 0.69 Pain Relevance 0
Validating induction of Hdc, TREM-1, PUMA-g, Irg1 and PROK-2 mRNAs by MSU crystals in the air pouch membrane
Positive_regulation (induction) of Hdc associated with crystal associated disease
14) Confidence 0.52 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 0.22 Pain Relevance 0.03
Our results, however, suggest that histamine may also arise from increased Hdc levels during MSU crystal inflammation.
Positive_regulation (increased) of Hdc associated with inflammation and crystal associated disease
15) Confidence 0.52 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 1.22 Pain Relevance 0.48
The possible participation of histidine decarboxylase in gastric lesions is discussed on the basis of the known actions of histamine, our findings and the effect of histamine H(2) receptor antagonists on histidine decarboxylase activity.
Spec (possible) Positive_regulation (participation) of histidine decarboxylase associated with antagonist
16) Confidence 0.49 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12535861 Disease Relevance 0.28 Pain Relevance 0.25
Our results indicate that LPS stimulated marked elevations of HDC activity in dental pulp and gingiva.
Positive_regulation (stimulated) of HDC in gingiva
17) Confidence 0.47 Published 2006 Journal Arch. Oral Biol. Section Abstract Doc Link 16769033 Disease Relevance 0.16 Pain Relevance 0.04
Our results indicate that LPS stimulated marked elevations of HDC activity in dental pulp and gingiva.
Positive_regulation (elevations) of HDC in gingiva
18) Confidence 0.47 Published 2006 Journal Arch. Oral Biol. Section Abstract Doc Link 16769033 Disease Relevance 0.16 Pain Relevance 0.04
Still, the relative increase in LPS-induced HDC activity in dental pulp and gingiva were much greater than that in ear skin.
Positive_regulation (induced) of HDC in ear skin
19) Confidence 0.47 Published 2006 Journal Arch. Oral Biol. Section Abstract Doc Link 16769033 Disease Relevance 0.23 Pain Relevance 0.06
Following 1-day treatment of RCS, stomach HDC activity, but not its mRNA level, increased two fold.
Positive_regulation (increased) of HDC in stomach associated with stress
20) Confidence 0.47 Published 1995 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 8750791 Disease Relevance 0.85 Pain Relevance 0.09

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