INT62360

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Context Info
Confidence 0.70
First Reported 1995
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 31
Total Number 32
Disease Relevance 28.23
Pain Relevance 3.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PTHLH) intracellular (PTHLH) cell-cell signaling (PTHLH)
cytoplasm (PTHLH) extracellular space (PTHLH) extracellular region (PTHLH)
Anatomy Link Frequency
parathyroid 6
mammary gland 2
erythrocyte 1
MDA-MB-231 1
urine 1
PTHLH (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 62 98.80 Very High Very High Very High
Osteoarthritis 180 98.70 Very High Very High Very High
Inflammation 94 98.06 Very High Very High Very High
rheumatoid arthritis 68 97.76 Very High Very High Very High
palliative 7 95.84 Very High Very High Very High
Pain 18 95.52 Very High Very High Very High
Arthritis 52 95.20 Very High Very High Very High
abdominal pain 2 94.28 High High
Mechanotransduction 32 93.36 High High
vincristine 3 83.80 Quite High
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 78 100.00 Very High Very High Very High
Hypercalcemia 222 99.86 Very High Very High Very High
Necrosis 1 99.34 Very High Very High Very High
Myeloid Leukemia 9 99.20 Very High Very High Very High
Cancer 214 99.16 Very High Very High Very High
Galactorrhea 222 99.04 Very High Very High Very High
Metastasis 102 99.00 Very High Very High Very High
Pancreatitis 4 98.84 Very High Very High Very High
Small Cell Lung Cancer 4 98.72 Very High Very High Very High
Frailty 184 98.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both serum calcium and PTH-rP levels were elevated.
Positive_regulation (elevated) of PTH-rP
1) Confidence 0.70 Published 2008 Journal J Hepatobiliary Pancreat Surg Section Abstract Doc Link 18836809 Disease Relevance 1.59 Pain Relevance 0.09
On admission, when the patient's serum calcium level was 16.0 mg/dl, his serum parathyroid hormone-related protein (PTHrP) level was elevated to 118.3 pmol/l.
Positive_regulation (elevated) of PTHrP in parathyroid
2) Confidence 0.70 Published 2002 Journal Rinsho Ketsueki Section Abstract Doc Link 11925871 Disease Relevance 1.02 Pain Relevance 0.12
On admission, when the patient's serum calcium level was 16.0 mg/dl, his serum parathyroid hormone-related protein (PTHrP) level was elevated to 118.3 pmol/l.
Positive_regulation (elevated) of parathyroid hormone-related protein in parathyroid
3) Confidence 0.70 Published 2002 Journal Rinsho Ketsueki Section Abstract Doc Link 11925871 Disease Relevance 1.04 Pain Relevance 0.12
Furthermore, RT-PCR analysis revealed that the patient's CML cells expressed PTHrP mRNA, and a high level of PTHrP was detected in the supernatant of cultured mononuclear cells derived from the patient's peripheral blood.
Positive_regulation (level) of PTHrP in blood associated with myeloid leukemia
4) Confidence 0.70 Published 2002 Journal Rinsho Ketsueki Section Abstract Doc Link 11925871 Disease Relevance 0.99 Pain Relevance 0.11
Laboratory findings revealed a decreased parathyroid hormone (PTH) level and marked elevation of parathyroid hormone-related protein (PTHRP).
Positive_regulation (elevation) of PTHRP in parathyroid
5) Confidence 0.69 Published 1995 Journal Surg. Today Section Abstract Doc Link 8640024 Disease Relevance 1.14 Pain Relevance 0.09
CONCLUSIONS: These data indicate a central role for TGFbeta in the pathogenesis of osteolytic bone metastases from breast carcinoma by 1) the induction of PTHrP through the Smad signaling pathway and 2) the potentiation of ER-alpha-mediated transcription induced by a constitutively active ER-alpha.
Positive_regulation (induction) of PTHrP
6) Confidence 0.67 Published 2000 Journal Cancer Section Body Doc Link 10898330 Disease Relevance 0 Pain Relevance 0
The parathyroid hormone-related peptide (PTHrP) was elevated at 2.5 units (normal < 1.8).
Positive_regulation (elevated) of PTHrP in parathyroid
7) Confidence 0.66 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1950877 Disease Relevance 1.07 Pain Relevance 0
PTHrP, which was elevated in our patient, plays a key role in the humoral hypercalcaemia of malignancy.
Positive_regulation (elevated) of PTHrP associated with malignant neoplastic disease and hypercalcemia
8) Confidence 0.66 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1950877 Disease Relevance 1.73 Pain Relevance 0.11
It should be noted here that the concentrations of C-PTHrP in our carrier patients were much lower than those in RA patients [18], and were not correlated with erythrocyte sedimentation rate or C-reactive protein, suggesting that the mechanism(s) involved in the activation of PTHrP in HTLV-I associated monoarthritis differ from that of RA.
Positive_regulation (activation) of PTHrP in erythrocyte associated with rheumatoid arthritis
9) Confidence 0.65 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464878 Disease Relevance 1.09 Pain Relevance 0.50
Laboratory findings showed not only hypercalcemia, but also increased serum levels of PTHrP and a few of proinflammatory cytokines, such as TNF-alpha, and IL-6.
Positive_regulation (increased) of PTHrP associated with hypercalcemia and cytokine
10) Confidence 0.64 Published 2007 Journal Rinsho Ketsueki Section Abstract Doc Link 17695305 Disease Relevance 0.55 Pain Relevance 0.24
Laboratory findings revealed a decreased parathyroid hormone (PTH) level and marked elevation of parathyroid hormone-related protein (PTHRP).
Positive_regulation (elevation) of hormone-related protein in parathyroid
11) Confidence 0.60 Published 1995 Journal Surg. Today Section Abstract Doc Link 8640024 Disease Relevance 1.14 Pain Relevance 0.09
Although the duration of hyperprolactinemia was sufficient to produce expressible galactorrhea in a majority of the participants, breast milk PTHrP levels increase with increasing duration of lactation [51-53] and women with longstanding prolactinomas and lactating women [20,33,34] are exposed to elevated prolactin levels for months, not days.
Positive_regulation (increase) of PTHrP associated with galactorrhea and prolactinoma
12) Confidence 0.57 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1950489 Disease Relevance 0.42 Pain Relevance 0
There was also no increase in PTHrP during r-hPRL treatment, an observation that is surprising in light of the association between PTHrP and prolactin in lactating women and women with hyperprolactinemia [20,33,34] and interventional studies in animals [47,48].
Neg (no) Positive_regulation (increase) of PTHrP associated with galactorrhea
13) Confidence 0.57 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1950489 Disease Relevance 0.44 Pain Relevance 0
Nevertheless, it is possible that the duration of prolactin exposure in the current study was insufficient to increase PTHrP.
Positive_regulation (increase) of PTHrP
14) Confidence 0.57 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1950489 Disease Relevance 0.41 Pain Relevance 0
Inhibition of actomyosin contractility by blebbistatin and inhibition of ROCK-I by Y-27632 induced a significant decrease in PTHrP mRNA expression in both MDA-MB-231 and RWGT2 cells (Figure 4B), suggesting that the upregulation of PTHrP on rigid substrates is mediated by ROCK.
Positive_regulation (upregulation) of PTHrP in MDA-MB-231
15) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0 Pain Relevance 0.12
Because the level of blood parathyroid hormone-related protein was elevated, we considered that esophageal small cell carcinoma caused human hypercalcemia of malignancy and that metastatic bone tumors caused local osteolytic hypercalcemia, eventually leading to severe acute pancreatitis.
Positive_regulation (elevated) of parathyroid hormone-related protein in parathyroid associated with malignant neoplastic disease, pancreatitis, hypercalcemia, small cell lung cancer and bone cancer
16) Confidence 0.45 Published 2007 Journal Fukushima J Med Sci Section Abstract Doc Link 17957966 Disease Relevance 1.78 Pain Relevance 0.09
This effect, and the high levels of PTHrP, give rise to widespread bony resorption [2,7] and our patient's bone scan is consistent with this.
Positive_regulation (levels) of PTHrP
17) Confidence 0.44 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1950877 Disease Relevance 1.33 Pain Relevance 0.16
We present the case of an elderly Jamaican woman with severe hypercalcaemia and a raised PTHrP who was found to have lymphoma and was positive for HTLV-1.



Positive_regulation (positive) of PTHrP associated with lymphatic system cancer and hypercalcemia
18) Confidence 0.44 Published 2007 Journal J Med Case Reports Section Abstract Doc Link PMC1950877 Disease Relevance 0.71 Pain Relevance 0
In view of the co-existence of lymphoma and hypercalcaemia, with elevated PTHrP, in this woman of Jamaican origin, Human T cell lymphotrophic virus type-1 (HTLV-1) serology was sought, and was positive, giving a presumptive diagnosis of HTLV-1-induced acute adult T cell leukaemia/lymphoma (ATLL).


Positive_regulation (elevated) of PTHrP in T cell associated with leukemia, lymphatic system cancer, hypercalcemia and adult t-cell leukemia-lymphoma
19) Confidence 0.44 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1950877 Disease Relevance 1.41 Pain Relevance 0.10
Although Tax expression was not correlated with cytokine concentration in SF, probably owing to the time discrepancy between SF aspiration and tissue preparation, Tax expression in synoviocytes might be responsible, at least in part, for the increased concentrations of PTHrP, sIL-2R and IL-6 in SF of carrier patients.
Positive_regulation (increased) of PTHrP associated with cytokine
20) Confidence 0.44 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464878 Disease Relevance 0.68 Pain Relevance 0.27

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