INT62361

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Context Info
Confidence 0.43
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.22
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PTH) extracellular region (PTH) cell-cell signaling (PTH)
Anatomy Link Frequency
parathyroid 6
spine 2
PTH (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 1 88.00 High High
Pain 4 83.28 Quite High
headache 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bone Cancer 8 94.72 High High
Multiple Myeloma 8 93.56 High High
Cancer 4 93.36 High High
Hypercalcemia 29 92.44 High High
Metastasis 1 85.00 Quite High
Pain 4 83.28 Quite High
Osteoporosis 37 83.08 Quite High
Rickets 1 82.48 Quite High
Disease 2 80.80 Quite High
Carcinoma 3 80.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sufficient levels of vitamin D, assessed by measuring 25-hydroxyvitamin D (25(OH)D) concentrations, can be defined as the 25(OH)D concentration that either prevents an increase in parathyroid hormone (PTH), a serum calcium regulator suppressed by 25(OH)D, or optimizes calcium absorption [1].
Negative_regulation (prevents) of Positive_regulation (increase) of parathyroid hormone in parathyroid
1) Confidence 0.43 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC3017021 Disease Relevance 0.17 Pain Relevance 0.08
The reduced serum calcitriol in both patients and the elevated parathyroid hormone observed in the first patient before treatment returned to normal.
Negative_regulation (reduced) of Positive_regulation (elevated) of parathyroid hormone in parathyroid
2) Confidence 0.41 Published 1999 Journal Am. J. Med. Sci. Section Abstract Doc Link 10408763 Disease Relevance 0.74 Pain Relevance 0.06
Laboratory findings revealed a decreased parathyroid hormone (PTH) level and marked elevation of parathyroid hormone-related protein (PTHRP).
Negative_regulation (decreased) of Positive_regulation (elevation) of PTH in parathyroid
3) Confidence 0.41 Published 1995 Journal Surg. Today Section Abstract Doc Link 8640024 Disease Relevance 1.12 Pain Relevance 0.09
In the TOP trial, at month 18 PTH treatment increased lumbar spine BMD by 6.5%, compared with a 0.3% decrease in the placebo group (P = 0.001).18 There were also significantly greater increases in the PTH group in total hip (2.1%), femoral neck (2.5%), and trochanter BMD (1.6%).28 At the distal radius BMD decreased in the PTH group by a mean of 3.4% (P = 0.001).18
Negative_regulation (decreased) of Positive_regulation (increases) of PTH in spine
4) Confidence 0.37 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971708 Disease Relevance 0.19 Pain Relevance 0

General Comments

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