INT62372

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Context Info
Confidence 0.50
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 0.46
Pain Relevance 7.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
hypothalamus 2
neurons 2
internal 2
neural 2
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 324 100.00 Very High Very High Very High
mu opioid receptor 120 100.00 Very High Very High Very High
Endogenous opioid 4 100.00 Very High Very High Very High
Kinase C 79 99.92 Very High Very High Very High
Morphine 274 99.68 Very High Very High Very High
chemokine 8 99.68 Very High Very High Very High
Limbic system 4 99.68 Very High Very High Very High
tolerance 71 99.28 Very High Very High Very High
Analgesic 45 99.28 Very High Very High Very High
amygdala 5 96.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 3 93.72 High High
Urological Neuroanatomy 36 78.24 Quite High
Pain 8 78.24 Quite High
INFLAMMATION 1 76.08 Quite High
Hyperalgesia 1 70.16 Quite High
Nociception 14 5.00 Very Low Very Low Very Low
Opiate Addiction 14 5.00 Very Low Very Low Very Low
Pheochromocytoma 10 5.00 Very Low Very Low Very Low
Sprains And Strains 9 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the induction of MOR sensitization was not modified by any doses of MK-801, except for the case of combination of MOR (20 mg/kg) with MK-801 (1 mg/kg) which was highly toxic (i.e., eliciting death or a moribund condition).
Positive_regulation (induction) of Localization (sensitization) of MOR associated with death
1) Confidence 0.50 Published 1996 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 8640458 Disease Relevance 0.09 Pain Relevance 0.20
A second exposure to DAMGO (100 nM) following recovery of internalized muOR immunoreactivity at the cell surface induced a translocation of muOR immunoreactivity in the cytoplasm comparable to the one observed following the first exposure (46.89+/-3.11% versus 43.31+/-3.80%). muOR internalization was prevented by hyperosmolar sucrose, phenylarsine oxide or potassium depletion, which inhibit clathrin-mediated endocytosis. muOR recycling was prevented by pre-treatment with bafilomycin A1, an acidotropic agent that inhibits endosomal acidification, but not by the protein synthesis inhibitor, cycloheximide.
Positive_regulation (induced) of Localization (translocation) of muOR
2) Confidence 0.50 Published 2003 Journal Neuroscience Section Abstract Doc Link 12763066 Disease Relevance 0 Pain Relevance 0.45
These data imply that estrogen treatment stimulates the release of endogenous opioids that activate mu-OR in the limbic system and hypothalamus providing a "neurochemical signature" of steroid activation of these circuits.
Positive_regulation (stimulates) of Localization (release) of mu-OR in hypothalamus associated with endogenous opioid and limbic system
3) Confidence 0.37 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9570823 Disease Relevance 0 Pain Relevance 0.42
In this study, we used laser-scanning microscopy to demonstrate that estrogen treatment induces the translocation of mu-OR immunoreactivity (mu-ORi) from the membrane to an internal location in steroid-sensitive cell groups of the limbic system and hypothalamus.
Positive_regulation (induces) of Localization (translocation) of mu-OR immunoreactivity in internal associated with limbic system
4) Confidence 0.37 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9570823 Disease Relevance 0 Pain Relevance 0.47
translocates to the MOR, activated G?
Positive_regulation (activated) of Localization (translocates) of MOR associated with opioid receptor
5) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.06 Pain Relevance 1.40
These processes occur before repeated morphine administration leads to internalization and recycling of the neural MOR, a process mediated by GRKs and ?
Positive_regulation (leads) of Localization (internalization) of MOR in neural associated with opioid receptor and morphine
6) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.08 Pain Relevance 1.26
In cells treated with morphine, we observed an increase in MOR/GPR177 colocalization (Figure 5A, merged images), suggesting that morphine treatment may cause an increase in the association between the MOR and GPR177.
Positive_regulation (increase) of Localization (colocalization) of MOR associated with opioid receptor and morphine
7) Confidence 0.17 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2841195 Disease Relevance 0 Pain Relevance 1.27
Conversely, activation of chemokine receptors also induces heterologous desensitization of mu-opioid receptors (MOR), a class of key analgesic receptors on neurons.
Positive_regulation (induces) of Localization (desensitization) of MOR in neurons associated with chemokine, analgesic and mu opioid receptor
8) Confidence 0.05 Published 2005 Journal J. Leukoc. Biol. Section Abstract Doc Link 16204635 Disease Relevance 0.22 Pain Relevance 0.91
With 10 ┬ÁM forskolin added to each condition for 5 min, the inhibition of cAMP after 60 min of morphine exposure was visible (Fig. 4B), illustrating that the increased cAMP is not merely a result of desensitization of MOR with this high dose of morphine.
Neg (not) Positive_regulation (increased) of Localization (desensitization) of MOR associated with mu opioid receptor and morphine
9) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.34

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