INT62373

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 34
Total Number 35
Disease Relevance 25.87
Pain Relevance 22.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (NGF) signal transduction (NGF) extracellular space (NGF)
extracellular region (NGF)
Anatomy Link Frequency
nerve 10
skin 8
hippocampus 2
nociceptors 1
neuronal 1
NGF (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 321 100.00 Very High Very High Very High
diabetic neuropathy 55 99.92 Very High Very High Very High
Peripheral nerve injury 5 99.92 Very High Very High Very High
Inflammation 29 99.84 Very High Very High Very High
sodium channel 9 99.80 Very High Very High Very High
substance P 40 99.76 Very High Very High Very High
Pain 99 99.68 Very High Very High Very High
hypoalgesia 9 99.60 Very High Very High Very High
Hippocampus 17 99.52 Very High Very High Very High
Neuropeptide 32 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 72 99.92 Very High Very High Very High
Diabetic Neuropathy 54 99.92 Very High Very High Very High
Nervous System Injury 21 99.92 Very High Very High Very High
Neuroma 16 99.92 Very High Very High Very High
Diabetes Mellitus 114 99.84 Very High Very High Very High
INFLAMMATION 33 99.84 Very High Very High Very High
Mycobacterium Infection 15 99.84 Very High Very High Very High
Pain 82 99.68 Very High Very High Very High
Hypoalagesia 9 99.60 Very High Very High Very High
Cold Sores 375 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We describe an early length-dependent dysfunction of sensory small-diameter fibers, prior to dysfunction of sympathetic fibers, with depletion of skin NGF and the sensory neuropeptide substance P.
Negative_regulation (depletion) of NGF in sympathetic associated with nerve growth factor, neuropeptide and substance p
1) Confidence 0.59 Published 1996 Journal Nat. Med. Section Abstract Doc Link 8640566 Disease Relevance 1.05 Pain Relevance 1.01
Serum deprivation and NGF induce and modulate voltage-gated Na(+) currents in human astrocytoma cell lines.
Negative_regulation (deprivation) of NGF associated with anaplastic astrocytoma
2) Confidence 0.59 Published 2001 Journal Glia Section Title Doc Link 11284020 Disease Relevance 0.37 Pain Relevance 0.21
In diabetics, there was an early length-dependent dysfunction of small-diameter sensory fibres, with depletion of skin NGF and the sensory neuropeptide substance P.
Negative_regulation (depletion) of NGF in skin associated with nerve growth factor, diabetes mellitus, neuropeptide and substance p
3) Confidence 0.59 Published 1996 Journal Philos. Trans. R. Soc. Lond., B, Biol. Sci. Section Abstract Doc Link 8730784 Disease Relevance 0.91 Pain Relevance 0.56
Immunostaining showed depletion of NGF in keratinocytes in diabetic skin.
Negative_regulation (depletion) of NGF in skin associated with nerve growth factor and diabetes mellitus
4) Confidence 0.59 Published 1996 Journal Philos. Trans. R. Soc. Lond., B, Biol. Sci. Section Abstract Doc Link 8730784 Disease Relevance 1.08 Pain Relevance 0.61
NGF levels were decreased in leprosy-affected skin and nerve.
Negative_regulation (decreased) of NGF in skin associated with nerve growth factor and mycobacterium infection
5) Confidence 0.59 Published 1996 Journal Philos. Trans. R. Soc. Lond., B, Biol. Sci. Section Abstract Doc Link 8730784 Disease Relevance 1.10 Pain Relevance 0.58
In injured nerves, NGF levels were reduced when compared to intact nerve, except acutely distal to injury; NGF-immunostaining was seen in Schwann cells in distal segments, including neuromas.
Neg (except) Negative_regulation (reduced) of NGF in nerve associated with nerve growth factor, injury and neuroma
6) Confidence 0.59 Published 1996 Journal Philos. Trans. R. Soc. Lond., B, Biol. Sci. Section Abstract Doc Link 8730784 Disease Relevance 1.10 Pain Relevance 0.61
NGF levels were generally depleted in injured nerves, but relatively preserved acutely in nerve segments distal to injury.
Negative_regulation (depleted) of NGF in nerve associated with nerve growth factor and injury
7) Confidence 0.59 Published 1997 Journal Neuroreport Section Abstract Doc Link 9223080 Disease Relevance 0.61 Pain Relevance 0.62
To explain the mechanism at the basis of this analgesic effect different hypotheses have been proposed: effect on inflammatory cells, reduction of basal NGF tone, induction of beta-endorphin release from keratinocytes, direct action on nociceptors.
Negative_regulation (reduction) of NGF in nociceptors associated with inflammation, nociceptor and analgesic
8) Confidence 0.57 Published 2009 Journal J. Soc. Biol. Section Abstract Doc Link 19358815 Disease Relevance 0.95 Pain Relevance 1.38
Immunostaining shows depletion of NGF in keratinocytes in diabetic skin.
Negative_regulation (depletion) of NGF in keratinocytes associated with nerve growth factor and diabetes mellitus
9) Confidence 0.43 Published 1996 Journal Nat. Med. Section Abstract Doc Link 8640566 Disease Relevance 1.14 Pain Relevance 0.98
We propose that a decrease in endogenous skin-derived NGF influences the presentation of diabetic polyneuropathy, although metabolic or vascular abnormalities may be the cause of the neuropathy.
Negative_regulation (decrease) of NGF in skin associated with nerve growth factor, congenital anomalies, diabetic neuropathy and neuropathic pain
10) Confidence 0.43 Published 1996 Journal Nat. Med. Section Abstract Doc Link 8640566 Disease Relevance 1.18 Pain Relevance 0.96
In animal models, NGF is depleted in diabetic nerves and NGF deprivation produces hypoalgesia.
Negative_regulation (deprivation) of NGF in nerves associated with nerve growth factor, diabetes mellitus and hypoalgesia
11) Confidence 0.43 Published 1996 Journal Nat. Med. Section Abstract Doc Link 8640566 Disease Relevance 0.59 Pain Relevance 0.80
In animal models, NGF is depleted in diabetic nerves and NGF deprivation produces hypoalgesia.
Negative_regulation (depleted) of NGF in nerves associated with nerve growth factor, diabetes mellitus and hypoalgesia
12) Confidence 0.43 Published 1996 Journal Nat. Med. Section Abstract Doc Link 8640566 Disease Relevance 0.53 Pain Relevance 0.78
We describe a significant correlation between NGF depletion and decreased skin axon-reflex vasodilation, mediated by small sensory fibers partly via substance P release.
Negative_regulation (depletion) of NGF in skin associated with nerve growth factor, increased venous pressure under development and substance p
13) Confidence 0.43 Published 1996 Journal Nat. Med. Section Abstract Doc Link 8640566 Disease Relevance 1.09 Pain Relevance 1.00
The NGF depletion correlated significantly with decreased skin axon-reflex vasodilatation, which is mediated by small sensory fibres at least partly via substance P release.
Negative_regulation (depletion) of NGF in skin associated with nerve growth factor, increased venous pressure under development and substance p
14) Confidence 0.43 Published 1996 Journal Philos. Trans. R. Soc. Lond., B, Biol. Sci. Section Abstract Doc Link 8730784 Disease Relevance 1.02 Pain Relevance 0.57
Decreased NGF in leprosy skin may explain cutaneous hypoalgesia even with inflammation and rhNGF may restore sensation, as spared nerve fibers show Trk A-staining.
Negative_regulation (Decreased) of NGF in nerve associated with inflammation, nerve growth factor, mycobacterium infection, trk a and hypoalgesia
15) Confidence 0.43 Published 2004 Journal Prog. Brain Res. Section Abstract Doc Link 14699981 Disease Relevance 1.18 Pain Relevance 0.74
While NGF levels are acutely reduced in injured nerve trunks, neuropathic patients with chronic skin hyperalgesia and allodynia show marked local increases of NGF levels; here anti-NGF agents may provide analgesia.
Negative_regulation (reduced) of NGF in skin associated with hyperalgesia, allodynia, nerve growth factor, neuropathic pain and analgesia
16) Confidence 0.43 Published 2004 Journal Prog. Brain Res. Section Abstract Doc Link 14699981 Disease Relevance 1.15 Pain Relevance 1.28
NGF is depleted in early human diabetic neuropathy skin, in correlation with dysfunction of nociceptor fibers.
Negative_regulation (depleted) of NGF in skin associated with nerve growth factor, nociceptor and diabetic neuropathy
17) Confidence 0.43 Published 2004 Journal Prog. Brain Res. Section Abstract Doc Link 14699981 Disease Relevance 1.22 Pain Relevance 0.82
It remains to be tested whether recombinant human NGF prevents, stabilizes, or ameliorates small fiber human neuropathies.
Spec (whether) Negative_regulation (prevents) of NGF associated with nerve growth factor
18) Confidence 0.43 Published 1997 Journal Neurology Section Abstract Doc Link 9040746 Disease Relevance 1.03 Pain Relevance 1.17
In addition, evidence shows that reduced availability of NGF may contribute to the pathogenesis of diabetic neuropathy, and animal models of neuropathy respond to the exogenous administration of NGF.
Negative_regulation (reduced) of NGF associated with nerve growth factor, diabetic neuropathy and neuropathic pain
19) Confidence 0.43 Published 2002 Journal Int. Rev. Neurobiol. Section Abstract Doc Link 12198818 Disease Relevance 0.67 Pain Relevance 0.58
Furthermore, blocking exogenous NGF or BDNF by binding it to antibody prevents tarenflurbil from protecting human neuronal cells from Abeta_{42} and H_{2}O_{2} cytotoxicity.
Negative_regulation (blocking) of NGF in neuronal associated with nerve growth factor
20) Confidence 0.43 Published 2008 Journal J. Alzheimers Dis. Section Abstract Doc Link 18997293 Disease Relevance 0.33 Pain Relevance 0.38

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