INT62374

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2010
Negated 2
Speculated 9
Reported most in Abstract
Documents 158
Total Number 168
Disease Relevance 77.87
Pain Relevance 76.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (NGF) signal transduction (NGF) extracellular space (NGF)
extracellular region (NGF)
Anatomy Link Frequency
nerve 39
nociceptor 8
skin 6
sensory nerve 5
brain 4
NGF (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 2791 100.00 Very High Very High Very High
Pain 1382 100.00 Very High Very High Very High
substance P 444 100.00 Very High Very High Very High
Neuropeptide 345 100.00 Very High Very High Very High
nociceptor 126 100.00 Very High Very High Very High
nMDA receptor 19 100.00 Very High Very High Very High
Hyperalgesia 54 99.96 Very High Very High Very High
Inflammation 512 99.84 Very High Very High Very High
dexamethasone 91 99.84 Very High Very High Very High
neuralgia 13 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 88 100.00 Very High Very High Very High
Lung Cancer 411 99.98 Very High Very High Very High
Pain 1375 99.96 Very High Very High Very High
Rheumatoid Arthritis 555 99.84 Very High Very High Very High
INFLAMMATION 544 99.84 Very High Very High Very High
Nociception 270 99.84 Very High Very High Very High
Diabetes Mellitus 93 99.84 Very High Very High Very High
Cold Sores 1107 99.82 Very High Very High Very High
Stroke 329 99.80 Very High Very High Very High
Death 115 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NGF and glial cell line-derived neurotrophic factor (GDNF) are both produced by basal keratinocytes and neurotrophin (NT-3) by suprabasal keratinocytes: relative mRNA expression was significantly lower in early diabetic neuropathy skin compared to controls, for NGF (P < 0.02), BDNF (P < 0.05), NT-3 (P < 0.05), GDNF (< 0.02), but not NT4/5, Trk A or p75 neurotrophin receptor (all P > 0.05).
Gene_expression (produced) of NGF in keratinocytes associated with nerve growth factor, trk a and diabetic neuropathy
1) Confidence 0.78 Published 2004 Journal Prog. Brain Res. Section Abstract Doc Link 14699981 Disease Relevance 1.34 Pain Relevance 0.97
The prostate is one of the most abundant sources of nerve growth factor (NGF) in different species, including humans.
Gene_expression (sources) of nerve growth factor in nerve associated with nerve growth factor
2) Confidence 0.78 Published 2010 Journal Growth Factors Section Abstract Doc Link 20166899 Disease Relevance 0.40 Pain Relevance 0.29
The co-expression of both NGF receptors, p75(NGFR) and tropomyosin-related kinase A (trkA), represents a crucial condition for the antiproliferative effect of NGF; indeed, p75(NGFR) is progressively lost during prostate tumorigenesis and its disappearance represents a malignancy marker of prostate adenocarcinoma (PCa).
Gene_expression (co-expression) of NGF associated with malignant neoplastic disease, nerve growth factor and prostate cancer
3) Confidence 0.78 Published 2010 Journal Growth Factors Section Abstract Doc Link 20166899 Disease Relevance 0.62 Pain Relevance 0.37
The prostate is one of the most abundant sources of nerve growth factor (NGF) in different species, including humans.
Gene_expression (sources) of NGF in nerve associated with nerve growth factor
4) Confidence 0.78 Published 2010 Journal Growth Factors Section Abstract Doc Link 20166899 Disease Relevance 0.40 Pain Relevance 0.29
The high-affinity NGF receptor, trkA, is selectively expressed by nociceptive sensory neurons particularly those containing sensory neuropeptides such as substance P and CGRP. 4.
Gene_expression (expressed) of NGF in sensory neurons associated with nociception, nerve growth factor, neuropeptide and substance p
5) Confidence 0.78 Published 1996 Journal Philos. Trans. R. Soc. Lond., B, Biol. Sci. Section Abstract Doc Link 8730782 Disease Relevance 0.79 Pain Relevance 1.03
The endogenous production of NGF regulates the sensitivity of nociceptive systems.
Gene_expression (production) of NGF associated with nociception and nerve growth factor
6) Confidence 0.78 Published 1996 Journal Philos. Trans. R. Soc. Lond., B, Biol. Sci. Section Abstract Doc Link 8730782 Disease Relevance 0.57 Pain Relevance 0.75
Behavioural and electrophysiological studies have shown that sequestration of constitutively produced NGF leads to decrease nociceptor sensitivity. 2.
Gene_expression (produced) of NGF in nociceptor associated with nerve growth factor and nociceptor
7) Confidence 0.78 Published 1996 Journal Philos. Trans. R. Soc. Lond., B, Biol. Sci. Section Abstract Doc Link 8730782 Disease Relevance 0.64 Pain Relevance 0.88
RESULTS: Both doses of NGF produced significant improvements in average and maximum daily pain compared with placebo.
Gene_expression (produced) of NGF
8) Confidence 0.77 Published 2000 Journal Neurology Section Body Doc Link 10720278 Disease Relevance 0.12 Pain Relevance 0
There was no difference in NGF and TrkA expression between early (stages I and II) and advanced (stage III) tumor stages and between well-/moderately differentiated (grades 1 and 2) and poorly differentiated (grade 3) tumors.
Gene_expression (expression) of NGF
9) Confidence 0.77 Published 1999 Journal J. Clin. Oncol. Section Body Doc Link 10561305 Disease Relevance 0.13 Pain Relevance 0
However, tumors with high NGF/TrkA expression levels exhibited more frequent perineural invasion (P <.01).
Gene_expression (expression) of NGF
10) Confidence 0.77 Published 1999 Journal J. Clin. Oncol. Section Body Doc Link 10561305 Disease Relevance 0.11 Pain Relevance 0
Following subcutaneous inoculation of HSV vectors expressing nerve growth factor (NGF) or neurotrophin-3 (NT-3), neurons in the DRG were transduced to produce NGF or NT-3 in vivo.
Gene_expression (produce) of NGF in neurons associated with cold sores and nerve growth factor
11) Confidence 0.77 Published 2004 Journal Brain Section Abstract Doc Link 14749293 Disease Relevance 0.77 Pain Relevance 0.32
Following subcutaneous inoculation of HSV vectors expressing nerve growth factor (NGF) or neurotrophin-3 (NT-3), neurons in the DRG were transduced to produce NGF or NT-3 in vivo.
Gene_expression (expressing) of nerve growth factor in neurons associated with cold sores and nerve growth factor
12) Confidence 0.77 Published 2004 Journal Brain Section Abstract Doc Link 14749293 Disease Relevance 0.77 Pain Relevance 0.31
Following subcutaneous inoculation of HSV vectors expressing nerve growth factor (NGF) or neurotrophin-3 (NT-3), neurons in the DRG were transduced to produce NGF or NT-3 in vivo.
Gene_expression (expressing) of NGF in neurons associated with cold sores and nerve growth factor
13) Confidence 0.77 Published 2004 Journal Brain Section Abstract Doc Link 14749293 Disease Relevance 0.77 Pain Relevance 0.31
DISCUSSION: We did not detect any difference between patients with neuropathic versus nociceptive pain and nonpainful controls for spinal CNTF, BDNF, and NGF levels.
Gene_expression (levels) of NGF in spinal
14) Confidence 0.77 Published 2009 Journal Clin J Pain Section Body Doc Link 19920725 Disease Relevance 0.21 Pain Relevance 0
TGF-beta1 increased expression and synthesis of both fibronectin and nerve growth factor (NGF), whereas dexamethasone stimulated fibronectin synthesis but inhibited NGF expression.
Gene_expression (expression) of NGF in nerve associated with nerve growth factor and dexamethasone
15) Confidence 0.76 Published 2007 Journal J Endod Section Abstract Doc Link 17931932 Disease Relevance 0.17 Pain Relevance 0.68
TGF-beta1 increased expression and synthesis of both fibronectin and nerve growth factor (NGF), whereas dexamethasone stimulated fibronectin synthesis but inhibited NGF expression.
Gene_expression (expression) of NGF in nerve associated with nerve growth factor and dexamethasone
16) Confidence 0.76 Published 2007 Journal J Endod Section Abstract Doc Link 17931932 Disease Relevance 0.16 Pain Relevance 0.70
The application of both TGF-beta1 and dexamethasone resulted in an additional effect on fibronectin; however, dexamethasone inhibited the TGF-beta1-induced NGF expression.
Gene_expression (expression) of NGF associated with nerve growth factor and dexamethasone
17) Confidence 0.76 Published 2007 Journal J Endod Section Abstract Doc Link 17931932 Disease Relevance 0.14 Pain Relevance 0.71
TGF-beta1 increased expression and synthesis of both fibronectin and nerve growth factor (NGF), whereas dexamethasone stimulated fibronectin synthesis but inhibited NGF expression.
Gene_expression (expression) of nerve growth factor in nerve associated with nerve growth factor and dexamethasone
18) Confidence 0.76 Published 2007 Journal J Endod Section Abstract Doc Link 17931932 Disease Relevance 0.17 Pain Relevance 0.68
Different roles of dexamethasone on transforming growth factor-beta1-induced fibronectin and nerve growth factor expression in dental pulp cells.
Gene_expression (expression) of nerve growth factor in dental pulp associated with nerve growth factor and dexamethasone
19) Confidence 0.76 Published 2007 Journal J Endod Section Title Doc Link 17931932 Disease Relevance 0.19 Pain Relevance 0.60
Nicotine is one such agent, which, when administered directly to the hippocampus in rats, produces long-lasting elevation of NGF production.
Gene_expression (production) of NGF in hippocampus associated with nerve growth factor, nicotine and hippocampus
20) Confidence 0.76 Published 2001 Journal Biol. Psychiatry Section Abstract Doc Link 11230869 Disease Relevance 0.56 Pain Relevance 0.82

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