INT62386

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Context Info
Confidence 0.20
First Reported 1996
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 7.94
Pain Relevance 3.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IGHG3)
Anatomy Link Frequency
T-cells 4
plasma 2
blood 2
IGHG3 (Homo sapiens)
Pain Link Frequency Relevance Heat
intrathecal 2 100.00 Very High Very High Very High
opioid receptor 2 99.84 Very High Very High Very High
Opioid 4 99.62 Very High Very High Very High
corticosteroid 3 98.76 Very High Very High Very High
agonist 7 97.52 Very High Very High Very High
Inflammation 89 94.48 High High
Multiple sclerosis 8 93.84 High High
Neuritis 8 92.96 High High
backache 1 91.24 High High
nud 1 90.84 High High
Disease Link Frequency Relevance Heat
Disease 109 100.00 Very High Very High Very High
Apoptosis 37 99.70 Very High Very High Very High
Asymptomatic Infections 4 98.64 Very High Very High Very High
Pancreatitis 40 95.08 Very High Very High Very High
Lumbar Puncture Related Headaches 2 95.04 Very High Very High Very High
INFLAMMATION 103 94.48 High High
Demyelinating Disease 8 93.84 High High
Targeted Disruption 2 93.44 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 67 93.28 High High
Malaria 163 93.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although class switching appears to be influenced by intensity of antigen stimulation and the age of the individual, young children appear to be deficient in promoting IgG3 production (17).
Negative_regulation (deficient) of Gene_expression (production) of IgG3
1) Confidence 0.20 Published 2009 Journal Parasite Immunology Section Body Doc Link PMC2759986 Disease Relevance 0.47 Pain Relevance 0
Corticosteroid therapy resulted in improvement of the clinical findings and lowered his serum IgG4 levels.
Negative_regulation (lowered) of Gene_expression (levels) of IgG4 associated with corticosteroid
2) Confidence 0.14 Published 2008 Journal Pathol. Int. Section Abstract Doc Link 18577110 Disease Relevance 2.17 Pain Relevance 0.89
Plasma IgG levels decreased with increasing TCDD plasma concentration (r = -0.35, p = 0.0002).
Negative_regulation (decreased) of Gene_expression (levels) of IgG in plasma
3) Confidence 0.09 Published 2002 Journal Environ Health Perspect Section Abstract Doc Link PMC1241102 Disease Relevance 0.34 Pain Relevance 0.09
Treatment resulted in a decrease in the concentration of myelin basic protein, a decrease in the serum concentration of immunoglobulin G (IgG) and intrathecal IgG synthesis, an increase in the cerebrospinal fluid concentration of transforming growth factor-beta1, and changes in the expression of CD25, CD26, and human leukocyte antigen-DR (HLA-DR) on CD4 T-cells.
Negative_regulation (decrease) of Gene_expression (synthesis) of IgG in T-cells associated with intrathecal
4) Confidence 0.04 Published 2000 Journal Eur. J. Neurol. Section Abstract Doc Link 10886311 Disease Relevance 0.66 Pain Relevance 0.53
Inhibition of IgG production by opioid receptor class (mu-, kappa-, and delta-) selective agonists.
Negative_regulation (Inhibition) of Gene_expression (production) of IgG associated with agonist and opioid receptor
5) Confidence 0.04 Published 1996 Journal J. Neuroimmunol. Section Title Doc Link 8642060 Disease Relevance 0.14 Pain Relevance 0.58
In our study, the IgM antibody levels determined by ELISA on the sera obtained at admission were all above the cutoff levels in all patients, but the IgG levels remained within the normal range in 4 cases.
Negative_regulation (remained) of Gene_expression (levels) of IgG
6) Confidence 0.03 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779323 Disease Relevance 0.52 Pain Relevance 0
The ability of whole blood to produce IgM and IgG following stimulation is also strongly inhibited.
Negative_regulation (inhibited) of Gene_expression (produce) of IgG in blood
7) Confidence 0.03 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15728468 Disease Relevance 0.36 Pain Relevance 0.43
Treatment resulted in a decrease in the concentration of myelin basic protein, a decrease in the serum concentration of immunoglobulin G (IgG) and intrathecal IgG synthesis, an increase in the cerebrospinal fluid concentration of transforming growth factor-beta1, and changes in the expression of CD25, CD26, and human leukocyte antigen-DR (HLA-DR) on CD4 T-cells.
Negative_regulation (decrease) of Gene_expression (synthesis) of IgG in T-cells associated with intrathecal
8) Confidence 0.03 Published 2000 Journal Eur. J. Neurol. Section Abstract Doc Link 10886311 Disease Relevance 0.65 Pain Relevance 0.52
Allergen-injection immunotherapy may induce IL-10 Tregs, leading to both suppression of Th2 responses and a switch from IgE to IgG4 antibody production [73].
Negative_regulation (switch) of Gene_expression (production) of IgG4
9) Confidence 0.02 Published 2006 Journal BMC Med Section Body Doc Link PMC1618394 Disease Relevance 1.10 Pain Relevance 0.17
Pathology of IgG4 disease
Negative_regulation (Pathology) of Gene_expression (disease) of IgG4 associated with disease
10) Confidence 0.02 Published 2006 Journal BMC Med Section Body Doc Link PMC1618394 Disease Relevance 0.86 Pain Relevance 0.31
Given that HAART initiated 4 h p.i. fully prevented apoptosis but partially reduced in vitro IgG production, independent control mechanisms may be involved.
Negative_regulation (reduced) of Gene_expression (production) of IgG associated with apoptosis
11) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695011 Disease Relevance 0.50 Pain Relevance 0.10
(Figure 2.C), but led to a 50% decrease in IL2+IL10-induced IgG production in vitro (data not shown).
Negative_regulation (decrease) of Gene_expression (production) of IgG
12) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695011 Disease Relevance 0.16 Pain Relevance 0

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