INT6239

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Context Info
Confidence 0.45
First Reported 1992
Last Reported 2004
Negated 1
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 0.34
Pain Relevance 7.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)
Anatomy Link Frequency
neurons 4
cerebral cortex 2
Oprd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 22 100.00 Very High Very High Very High
Opioid 17 100.00 Very High Very High Very High
analgesia 11 100.00 Very High Very High Very High
mu opioid receptor 5 100.00 Very High Very High Very High
Dopamine 3 100.00 Very High Very High Very High
cytokine 1 100.00 Very High Very High Very High
Analgesic 1 100.00 Very High Very High Very High
agonist 12 98.70 Very High Very High Very High
antinociception 1 97.88 Very High Very High Very High
Morphine 25 97.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 2 100.00 Very High Very High Very High
Hyperalgesia 5 97.24 Very High Very High Very High
Influenza Virus Infection 1 5.00 Very Low Very Low Very Low
Opiate Addiction 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study we have analyzed the regulation of delta-opioid receptor mRNA and the regulation of delta-opioid receptor activated astroglial Ca2+ responses in primary cultures from the rat cerebral cortex.
Spec (analyzed) Regulation (regulation) of Spec (analyzed) Regulation (regulation) of delta-opioid receptor in cerebral cortex associated with opioid receptor and cerebral cortex
1) Confidence 0.45 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9302088 Disease Relevance 0 Pain Relevance 0.70
At the transcriptional level, most recent studies have revealed both positive and negative roles for various transcription factors, vitamin A hormones and cytokines in opioid receptor gene regulation.
Regulation (roles) of Regulation (regulation) of opioid receptor gene associated with opioid receptor and cytokine
2) Confidence 0.36 Published 2002 Journal Curr Opin Pharmacol Section Abstract Doc Link 11786311 Disease Relevance 0 Pain Relevance 0.34
This indicates that the absence of G(z alpha) does not affect opioid receptor affinity or receptor up or down regulation.
Neg (not) Regulation (affect) of Regulation (regulation) of opioid receptor associated with opioid receptor
3) Confidence 0.26 Published 2000 Journal Brain Res. Section Abstract Doc Link 10869496 Disease Relevance 0 Pain Relevance 1.25
However, the critical role of the endogenous glycolipid GM1 ganglioside in regulating Gs-coupled, excitatory opioid receptor functions has not been addressed in any of the recent reviews of opioid stimulatory mechanisms.
Regulation (role) of Regulation (regulating) of opioid receptor associated with opioid receptor and opioid
4) Confidence 0.26 Published 1998 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 9786023 Disease Relevance 0 Pain Relevance 0.69
Effect of adrenal and sex hormones on opioid analgesia and opioid receptor regulation.
Regulation (Effect) of Regulation (regulation) of opioid receptor associated with analgesic, opioid receptor, opioid and analgesia
5) Confidence 0.19 Published 1992 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 1325057 Disease Relevance 0 Pain Relevance 1.56
The present study investigated the molecular interactions of these two systems by determining the role of dopamine D1 and D2 receptors in the modulation of opioid receptor-mediated signal transduction.
Regulation (role) of Regulation (modulation) of opioid receptor associated with dopamine and opioid receptor
6) Confidence 0.09 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10698003 Disease Relevance 0 Pain Relevance 0.66
The endogenous glycolipid GM1 ganglioside plays a critical role in nociceptive neurons in regulating opioid receptor excitatory signaling demonstrated to mediate "paradoxical" morphine hyperalgesia and to contribute to opioid tolerance/dependence.
Regulation (role) of Regulation (regulating) of opioid receptor in neurons associated with nociception, addiction, hyperalgesia, tolerance, opioid receptor, opioid and morphine
7) Confidence 0.01 Published 2004 Journal Brain Res. Section Abstract Doc Link 14672816 Disease Relevance 0.34 Pain Relevance 1.10
These results provide the first evidence for the occurrence of mu receptor endocytosis in neurons by endogenously released opioids and show that agonist-dependent mu receptor endocytosis could serve as a mechanism to regulate mu opioid receptor responsiveness to ligand stimulation when the opioid receptor reserve is reduced.
Regulation (regulate) of Regulation (responsiveness) of opioid receptor in neurons associated with mu opioid receptor, agonist, opioid receptor and opioid
8) Confidence 0.00 Published 2000 Journal Neuroscience Section Abstract Doc Link 10854754 Disease Relevance 0 Pain Relevance 0.96

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