INT624

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Context Info
Confidence 0.70
First Reported 1976
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 28
Total Number 28
Disease Relevance 15.61
Pain Relevance 4.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GAST) extracellular region (GAST)
Anatomy Link Frequency
plasma 3
uncus 2
thickening 1
GAST (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 16 99.92 Very High Very High Very High
Enkephalin 3 99.32 Very High Very High Very High
Morphine 7 99.30 Very High Very High Very High
narcan 7 99.10 Very High Very High Very High
antagonist 12 98.54 Very High Very High Very High
Serotonin 14 98.32 Very High Very High Very High
abdominal pain 14 98.30 Very High Very High Very High
opiate 7 98.14 Very High Very High Very High
nud 76 98.08 Very High Very High Very High
Cholecystokinin 93 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Gastric Motility Disorder 1 99.80 Very High Very High Very High
Recurrence 11 99.76 Very High Very High Very High
Gastroesophageal Reflux Disease 446 99.66 Very High Very High Very High
Syndrome 37 99.46 Very High Very High Very High
Gastrinoma 25 99.42 Very High Very High Very High
Pathologic Constriction 6 98.94 Very High Very High Very High
Ulcers 86 98.40 Very High Very High Very High
Abdominal Pain 14 98.30 Very High Very High Very High
Dyspepsia 76 98.08 Very High Very High Very High
Metastasis 30 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this context, it should be kept in mind that some gastrinoma patients present without an elevation of serum gastrin levels.
Neg (without) Positive_regulation (elevation) of gastrin associated with gastrinoma
1) Confidence 0.70 Published 2010 Journal Med. Klin. (Munich) Section Abstract Doc Link 20455041 Disease Relevance 0.76 Pain Relevance 0.13
RESULTS: Median fasting serum gastrin levels increased from a pretreatment value of 74-145 pg/mL after 3 months.
Positive_regulation (increased) of gastrin
2) Confidence 0.70 Published 1993 Journal Gastroenterology Section Body Doc Link 8482449 Disease Relevance 0.09 Pain Relevance 0
Plasma radioimmunoassays showed elevated gastrin, chromogranin A and normal levels of gastrin-releasing peptide, and 9 other hormones.
Positive_regulation (elevated) of gastrin in Plasma
3) Confidence 0.69 Published 2001 Journal Gastroenterology Section Abstract Doc Link 11266390 Disease Relevance 1.87 Pain Relevance 0.20
RESULTS: Omeprazole increased serum gastrin levels from 64 (median; range, 52-91) pg/ml to 80.5 (median; range, 56-455) pg/ml (P < 0.05) but did not significantly affect the plasma concentration of aspirin or salicylic acid.
Positive_regulation (increased) of gastrin in plasma
4) Confidence 0.69 Published 2000 Journal Scand. J. Gastroenterol. Section Body Doc Link 10766315 Disease Relevance 0 Pain Relevance 0
After complete drug(s) administration, serum immunoreactive (ir) -gastrin levels increased significantly in the single group (P < 0.001) in contrast to the combination group, and plaunotol significantly inhibited hypergastrinemia induced by omeprazole administration (P < 0.001).
Positive_regulation (increased) of gastrin
5) Confidence 0.68 Published 1995 Journal Dig. Dis. Sci. Section Abstract Doc Link 7821104 Disease Relevance 0.73 Pain Relevance 0.19
We report the case of a 32-year-old Indian man with symptoms suggesting Zollinger-Ellison syndrome including abdominal pain, esaphagitis, duodenal stenosis that did not improve with antisecretory medication, elevated fasting gastrin serum levels that increased after intravenous secretin injections, elevated chromogranin A serum levels and tumoral aspect of pancreatic uncus on CT scan examination.
Positive_regulation (elevated) of gastrin in uncus associated with abdominal pain, pathologic constriction and syndrome
6) Confidence 0.67 Published 2005 Journal Gastroenterol. Clin. Biol. Section Abstract Doc Link 16505764 Disease Relevance 0.67 Pain Relevance 0.10
These studies indicate that an orally administered opiate-receptor antagonist can inhibit gastric acid secretion in response to a meal in humans, yet increase meal-stimulated serum gastrin concentrations.
Positive_regulation (increase) of gastrin associated with antagonist and opiate
7) Confidence 0.50 Published 1985 Journal Regul. Pept. Section Abstract Doc Link 4059587 Disease Relevance 0 Pain Relevance 0.36
In contrast to naloxone, morphine delayed gastric emptying and also enhanced the gastrin response to the meal.
Positive_regulation (enhanced) of gastrin associated with narcan, gastric motility disorder and morphine
8) Confidence 0.50 Published 1980 Journal Gastroenterology Section Abstract Doc Link 7399233 Disease Relevance 0.10 Pain Relevance 1.05
Double Antibody Gastrin Method is a radioimmunoassay technique for gastrin designed for the quantitative measurement of gastrin in serum, which utilizes labeled synthetic iodinated human gastrin (SHG I-17) (7).
Positive_regulation (measurement) of gastrin
9) Confidence 0.49 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808598 Disease Relevance 0.30 Pain Relevance 0.21
Moreover, enprostil inhibits postprandial gastrin release, whereas H2-blockers increase gastrin levels.
Positive_regulation (increase) of gastrin
10) Confidence 0.46 Published 1991 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 1940188 Disease Relevance 0.75 Pain Relevance 0.22
We report the case of a 32-year-old Indian man with symptoms suggesting Zollinger-Ellison syndrome including abdominal pain, esaphagitis, duodenal stenosis that did not improve with antisecretory medication, elevated fasting gastrin serum levels that increased after intravenous secretin injections, elevated chromogranin A serum levels and tumoral aspect of pancreatic uncus on CT scan examination.
Positive_regulation (increased) of gastrin in uncus associated with abdominal pain, pathologic constriction and syndrome
11) Confidence 0.45 Published 2005 Journal Gastroenterol. Clin. Biol. Section Abstract Doc Link 16505764 Disease Relevance 0.67 Pain Relevance 0.10
By the fourth month following a relapse, the serum gastrin level had significantly increased.
Positive_regulation (increased) of gastrin associated with recurrence
12) Confidence 0.44 Published 2002 Journal Dig. Dis. Sci. Section Abstract Doc Link 11991619 Disease Relevance 2.51 Pain Relevance 0.06
In 3 patients with Zollinger-Ellison syndrome, treated in the same way, elevated serum gastrin was reduced by about 50% and acid secretion by more than 90%.
Positive_regulation (elevated) of gastrin associated with syndrome
13) Confidence 0.38 Published 1976 Journal Z Gastroenterol Verh Section Abstract Doc Link 64056 Disease Relevance 0.51 Pain Relevance 0.17
One of the gastrointestinal motility regulatory factors has been assumed to be the induction of changes in the levels of peptides (gastrin, somatostatin and motilin) in plasma.
Positive_regulation (induction) of gastrin in plasma associated with somatostatin
14) Confidence 0.37 Published 2005 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 15969937 Disease Relevance 0 Pain Relevance 0.39
In the present study, there was a significant increase in the pH with a significant decrease in BAO and a significant increase in serum gastrin after melatonin therapy compared to pretreatment levels.
Positive_regulation (increase) of gastrin
15) Confidence 0.35 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2821302 Disease Relevance 0.26 Pain Relevance 0.03
In addition, there is a significant increase in the residual pressure, a significant decrease in the relaxation duration, a significant increase in the relaxation percentage, a significant increase in the pH with a significant decreased in BAO and a significant increase in serum gastrin and melatonin levels.
Positive_regulation (increase) of gastrin
16) Confidence 0.35 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2821302 Disease Relevance 0.45 Pain Relevance 0.08
There was also a non-significant change in the tone of the LES, a non-significant change in the residual pressure, relaxation duration, relaxation percentage, a significant increase in the pH with a significant decrease in BAO, a significant increase in serum gastrin and a non - significant increase in the melatonin level.
Positive_regulation (increase) of gastrin
17) Confidence 0.35 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2821302 Disease Relevance 0.87 Pain Relevance 0.15
There was also a significant increase in the tone of the LES in the form of increased LES pressure, a significant increase in the residual pressure, a significant decrease in the relaxation duration, a significant increase in the relaxation percentage, a significant increase in the pH with a significant decrease in BAO, and a significant increase in serum gastrin and mean melatonin levels relative to pretreated patients.
Positive_regulation (increase) of gastrin
18) Confidence 0.35 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2821302 Disease Relevance 0.77 Pain Relevance 0.12
It was found that melatonin accelerates the clinical and endoscopic improvement when combined with omeprazole as improvement in combination therapy was completed at shorter duration (at the fourth week) with no further increase in serum gastrin level.
Positive_regulation (increase) of gastrin
19) Confidence 0.35 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2821302 Disease Relevance 0.44 Pain Relevance 0
While patients treated with omeprazole alone or combined with melatonin showed a significant increase in PH and serum gastrin level with a significant decrease in BAO than melatonin alone, however, the combined therapy showed a non-significant increase in serum gastrin or BAO compared with omeprazole alone.
Positive_regulation (increase) of gastrin
20) Confidence 0.35 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2821302 Disease Relevance 0.14 Pain Relevance 0

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