INT62400

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Context Info
Confidence 0.67
First Reported 1996
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 34
Total Number 41
Disease Relevance 35.53
Pain Relevance 7.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 11
monocytes 9
mononuclear cells 6
neutrophil 4
microglia 2
Il1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1226 100.00 Very High Very High Very High
cytokine 865 100.00 Very High Very High Very High
anakinra 208 99.16 Very High Very High Very High
agonist 128 98.72 Very High Very High Very High
Inflammatory response 176 98.24 Very High Very High Very High
ischemia 80 96.96 Very High Very High Very High
Inflammatory mediators 57 95.76 Very High Very High Very High
chemokine 52 95.24 Very High Very High Very High
Central nervous system 40 88.56 High High
Multiple sclerosis 20 87.28 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 1453 100.00 Very High Very High Very High
Crystal Associated Disease 722 100.00 Very High Very High Very High
Adhesions 31 100.00 Very High Very High Very High
Injury 87 99.92 Very High Very High Very High
Targeted Disruption 135 99.82 Very High Very High Very High
Fever 130 99.80 Very High Very High Very High
Cancer 284 99.76 Very High Very High Very High
Dehydration 7 99.74 Very High Very High Very High
Apoptosis 279 99.66 Very High Very High Very High
Necrosis 75 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These genes are regulated separately, and coordinated induction in the same cell is required for secretion of the biologically active IL-12p70 heterodimer [236].
Positive_regulation (required) of Localization (secretion) of IL-1
1) Confidence 0.67 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.14 Pain Relevance 0.06
Apart from the inflammasome, IL-1 secretion by macrophages in contact with MSU can also be induced through a TLR-dependent mechanism [5].
Positive_regulation (induced) of Localization (secretion) of IL-1 in macrophages associated with crystal associated disease
2) Confidence 0.48 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906806 Disease Relevance 0.71 Pain Relevance 0.20
MSU and calcium pyrophosphate dihydrate crystals directly activate the inflammasome via NALP3 in monocytes or macrophages to release active IL-1?
Positive_regulation (active) of Localization (release) of IL-1 in macrophages associated with crystal associated disease
3) Confidence 0.35 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906806 Disease Relevance 0.77 Pain Relevance 0.18
MSU and calcium pyrophosphate dihydrate crystals directly activate the inflammasome via NALP3 in monocytes or macrophages to release active IL-1?
Positive_regulation (activate) of Localization (release) of IL-1 in macrophages associated with crystal associated disease
4) Confidence 0.35 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906806 Disease Relevance 0.79 Pain Relevance 0.18
A pilot study of IL-1 inhibition by anakinra in acute gout

Monosodium urate crystals stimulate monocytes and macrophages to release IL-1?

Positive_regulation (stimulate) of in macrophages Localization (release) of IL-1 in monocytes associated with anakinra and crystal associated disease
5) Confidence 0.35 Published 2007 Journal Arthritis Res Ther Section Title Doc Link PMC1906806 Disease Relevance 0.92 Pain Relevance 0.24
The recent finding that MSU crystals induce IL-1 release by activation of the NALP3 inflammasome led us to investigate whether IL-1 blockade could inhibit inflammation provoked by MSU.
Positive_regulation (induce) of Localization (release) of IL-1 associated with inflammation and crystal associated disease
6) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906806 Disease Relevance 1.06 Pain Relevance 0.40
Among the many cytokines implicated [2,3], IL-1 may have a special role in the inflammatory network, as MSU crystals stimulate IL-1 release by monocytes and synovial mononuclear cells [4].
Positive_regulation (stimulate) of Localization (release) of IL-1 in mononuclear cells associated with inflammation, crystal associated disease and cytokine
7) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906806 Disease Relevance 0.96 Pain Relevance 0.39
Two hours thereafter, peritoneal (pMphi) and splenic macrophages (sMphi) were harvested and assessed not only for their ability to release IL-1 and IL-6, but also for cytokine gene expression using semiquantitative reverse transcription and PCR.
Positive_regulation (assessed) of Localization (release) of IL-1 in splenic macrophages associated with cytokine
8) Confidence 0.26 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8955229 Disease Relevance 0.58 Pain Relevance 0.32
Microglial activation causes the release of free radicals [10] and of inflammatory cytokines, including IL-1?
Positive_regulation (causes) of Localization (release) of IL-1 associated with inflammation and cytokine
9) Confidence 0.24 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 1.19 Pain Relevance 0.30
B activation results from the rich abundance of IL1?
Positive_regulation (activation) of Localization (abundance) of IL1
10) Confidence 0.24 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.85 Pain Relevance 0.29
Previous studies from this laboratory had shown that exposure of mice to cold water stress leads to an increase in the secretion of interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF alpha) from their peritoneal macrophages.
Positive_regulation (increase) of Localization (secretion) of IL-1 in peritoneal macrophages associated with necrosis, cancer and dehydration
11) Confidence 0.19 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8642417 Disease Relevance 0.68 Pain Relevance 0.15
T lymphocyte mitogens such as Con A are thought to act through several subsequent steps, initially inducing IL-1 secretion in macrophages.
Positive_regulation (inducing) of Localization (secretion) of IL-1 in T lymphocyte
12) Confidence 0.18 Published 2005 Journal BMC Complement Altern Med Section Body Doc Link PMC1084244 Disease Relevance 0.37 Pain Relevance 0.06
The results show that MSU crystals initiate an inflammatory cascade, the starting point being the release of active IL-1?
Positive_regulation (active) of Localization (release) of IL-1 associated with inflammation and crystal associated disease
13) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 0.73 Pain Relevance 0.08
Macrophages deficient for components of the NLRP3 inflammasome were unable to secrete active IL-1?
Neg (unable) Positive_regulation (active) of Neg (unable) Localization (secrete) of IL-1 in Macrophages
14) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 0.59 Pain Relevance 0.03
A pilot study of IL-1 inhibition by anakinra in acute gout

Monosodium urate crystals stimulate monocytes and macrophages to release IL-1?

Positive_regulation (stimulate) of Localization (release) of IL-1 in monocytes associated with anakinra and crystal associated disease
15) Confidence 0.12 Published 2007 Journal Arthritis Res Ther Section Title Doc Link PMC1906806 Disease Relevance 0.92 Pain Relevance 0.24
TT was based on observations by several investigators who recognized that uric acid/urate crystals can stimulate secretion of IL-1?
Positive_regulation (stimulate) of Localization (secretion) of IL-1
16) Confidence 0.07 Published 2010 Journal Curr Allergy Asthma Rep Section Body Doc Link PMC2892083 Disease Relevance 1.04 Pain Relevance 0.15
In addition, transgenic sickle cell disease mice compared with wild mice exhibit a heightened proinflammatory state to microbial molecules, as marked by elevated neutrophil counts, increased secretion of soluble vascular adhesion molecules, and increased secretion of proinflammatory cytokines (IL-1?
Positive_regulation (increased) of Localization (secretion) of IL-1 in neutrophil associated with sickle cell anemia, targeted disruption, adhesions and cytokine
17) Confidence 0.07 Published 2010 Journal Curr Allergy Asthma Rep Section Body Doc Link PMC2892083 Disease Relevance 2.05 Pain Relevance 0.31
In addition, mononuclear cells from FMF patients release higher levels of IL-1?
Positive_regulation (levels) of Localization (release) of IL-1 in mononuclear cells associated with fever
18) Confidence 0.07 Published 2010 Journal Curr Allergy Asthma Rep Section Body Doc Link PMC2892083 Disease Relevance 1.98 Pain Relevance 0.24
Evidence also indicates that uric acid/urate crystals can stimulate secretion of IL-1?
Positive_regulation (stimulate) of Localization (secretion) of IL-1
19) Confidence 0.07 Published 2010 Journal Curr Allergy Asthma Rep Section Body Doc Link PMC2892083 Disease Relevance 1.11 Pain Relevance 0.15
The pathogenesis of lethal sepsis remains obscure, but is mediated in part by excessive release of early (e.g., TNF and IL-1) and late (e.g., HMGB1) proinflammatory cytokines.
Positive_regulation (mediated) of Localization (release) of IL-1 associated with sepsis and cytokine
20) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 1.03 Pain Relevance 0.19

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