INT62421

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Context Info
Confidence 0.68
First Reported 1996
Last Reported 2008
Negated 1
Speculated 3
Reported most in Abstract
Documents 8
Total Number 11
Disease Relevance 5.48
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpc2) nuclear envelope (Trpc2) plasma membrane (Trpc2)
nucleus (Trpc2) transmembrane transport (Trpc2)
Anatomy Link Frequency
tears 1
Blood 1
macrophage 1
aorta 1
melanocyte 1
Trpc2 (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 5 100.00 Very High Very High Very High
Sciatica 4 97.68 Very High Very High Very High
imagery 2 93.56 High High
TRP channel 50 75.04 Quite High
tetrodotoxin 1 67.52 Quite High
antagonist 1 50.16 Quite High
Pain 1 41.36 Quite Low
backache 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 161 100.00 Very High Very High Very High
Microphthalmia 9 100.00 Very High Very High Very High
Intervertebral Disk Degeneration 18 99.84 Very High Very High Very High
Glioblastoma 26 99.16 Very High Very High Very High
Nerve Root Compression 4 97.68 Very High Very High Very High
Skin Cancer 8 96.88 Very High Very High Very High
Disease 10 96.64 Very High Very High Very High
Recurrence 4 91.56 High High
Metastasis 1 89.16 High High
Obesity 2 87.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reverse transcription polymerase chain reaction examinations revealed expression of TRPC2, 4, and 6, as well as InsP3R1 and 2 in ICCs.
Gene_expression (expression) of TRPC2
1) Confidence 0.68 Published 2005 Journal J. Biol. Rhythms Section Abstract Doc Link 15654067 Disease Relevance 0 Pain Relevance 0.09
Since the only fibroblast chromosome detected in the unpigmented microcell hybrid was mouse chromosome 1, these results also suggest that the extinguisher locus affecting the expression of the tyrosinase, TRP-1, TRP-2, and microphthalmia genes in hybrid cells is located on that mouse chromosome (or on a fragment of another chromosome present in the unpigmented monochromosomal microcell hybrid but undetected in our analyses).
Gene_expression (expression) of TRP-2 in fibroblast associated with microphthalmia
2) Confidence 0.57 Published 1996 Journal Somat. Cell Mol. Genet. Section Abstract Doc Link 8643993 Disease Relevance 0.33 Pain Relevance 0.08
A pigmented subclone of this microcell hybrid, however, re-expressed the tyrosinase, TRP-1, TRP-2, and microphthalmia genes.
Gene_expression (expressed) of TRP-2 associated with microphthalmia
3) Confidence 0.57 Published 1996 Journal Somat. Cell Mol. Genet. Section Abstract Doc Link 8643993 Disease Relevance 0.34 Pain Relevance 0
In addition, we observed the presence of TRPC2 in the aorta, but very low signals for TRPC4 and C5.
Gene_expression (presence) of TRPC2 in aorta
4) Confidence 0.51 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0.09 Pain Relevance 0.07
Here we report analyses regarding expression of the melanocyte-stimulating hormone (MSH) receptor (melanocortin-1 receptor, MC1-R) and the melanogenic proteins, tyrosinase (E.C. 1.14.18.1), tyrosinase-related protein 1 (TRP-1), and the tyrosinase-related protein 2 (TRP-2, E.C. 5.3.2.3), by a panel of cell lines consisting of parental Cloudman S91 melanoma cells, macrophages from DBA/2J mice, artificially derived macrophage x melanoma hybrids of high and low metastatic potential, and a naturally occurring highly metastatic hybrid between a Cloudman S91 tumor cell and a DBA/2J tumor-infiltrating cell.
Spec (analyses) Gene_expression (expression) of TRP-2 in macrophage associated with melanocortin 1 receptor, cancer and skin cancer
5) Confidence 0.50 Published 1999 Journal Pigment Cell Res. Section Abstract Doc Link 10614575 Disease Relevance 0.62 Pain Relevance 0.17
Analysis of melanocyte-specific transcripts using reverse transcription, combined with the polymerase chain reaction (RT-PCR), demonstrated that tyrosinase, TRP-1, TRP-2, and microphthalmia transcripts were all absent in unpigmented whole-cell hybrids and in the monochromosomal unpigmented microcell hybrid.
Neg (absent) Gene_expression (absent) of TRP-2 in melanocyte associated with microphthalmia
6) Confidence 0.44 Published 1996 Journal Somat. Cell Mol. Genet. Section Abstract Doc Link 8643993 Disease Relevance 0.33 Pain Relevance 0
Trp2 was found only in affected individuals (4%), whereas Trp3 was present in both affected (24%) and unaffected (9%) individuals.
Gene_expression (found) of Trp2
7) Confidence 0.38 Published 2005 Journal Spine Section Body Doc Link 16371896 Disease Relevance 0.08 Pain Relevance 0
RESULTS: The Trp2 allele was present in 20% of the population and was associated with a fourfold increase in the risk of developing anular tears at 30 to 39 years and a 2.4-fold increase in the risk of developing DDD and endplate herniations at 40 to 49 years.
Gene_expression (present) of Trp2 in tears
8) Confidence 0.38 Published 2005 Journal Spine Section Body Doc Link 16371896 Disease Relevance 0.06 Pain Relevance 0
GBMs over express tumor antigens such as MAGE, Her2/neu, Tyrosinase, Trp-1, Trp-2, gp100, IL13R?
Gene_expression (express) of Trp-2 associated with cancer
9) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291560 Disease Relevance 2.15 Pain Relevance 0
However, it is not known whether the Trp2 or Trp3 alleles contribute to disc degeneration (DD).
Spec (whether) Gene_expression (contribute) of Trp2 associated with intervertebral disk degeneration
10) Confidence 0.10 Published 2006 Journal Eur Spine J Section Abstract Doc Link 16133074 Disease Relevance 0.73 Pain Relevance 0.13
Blood samples were analysed for the presence of COL9A3 and COL9A2 tryptophan alleles (Trp3 and Trp2 alleles).
Spec (analysed) Gene_expression (presence) of Trp2 in Blood
11) Confidence 0.10 Published 2006 Journal Eur Spine J Section Abstract Doc Link 16133074 Disease Relevance 0.77 Pain Relevance 0.12

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