INT62422

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Context Info
Confidence 0.62
First Reported 1996
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 2.28
Pain Relevance 5.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Mc1r) signal transduction (Mc1r) plasma membrane (Mc1r)
signal transducer activity (Mc1r)
Anatomy Link Frequency
dorsum 4
skin 2
melanocyte 2
pigmentation 2
body regions 2
Mc1r (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 349 100.00 Very High Very High Very High
Multiple sclerosis 5 99.20 Very High Very High Very High
agonist 18 87.44 High High
Inflammation 2 81.20 Quite High
antagonist 15 5.00 Very Low Very Low Very Low
tolerance 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 17 99.84 Very High Very High Very High
Cancer 8 99.48 Very High Very High Very High
Demyelinating Disease 5 99.20 Very High Very High Very High
Microphthalmia 3 81.76 Quite High
INFLAMMATION 2 81.20 Quite High
Stress 10 54.24 Quite High
Infection 1 34.16 Quite Low
Sprains And Strains 5 5.00 Very Low Very Low Very Low
Shock 5 5.00 Very Low Very Low Very Low
Bacterial Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Homologous regulation of melanocortin-1 receptor (MC1R) expression in melanoma tumor cells in vivo.
Regulation (regulation) of Gene_expression (expression) of melanocortin-1 receptor associated with melanocortin 1 receptor, cancer and skin cancer
1) Confidence 0.62 Published 2002 Journal J. Recept. Signal Transduct. Res. Section Title Doc Link 12503610 Disease Relevance 0.39 Pain Relevance 0.53
Here, we report on the regulation of melanocortin-1 receptor (MC1R) expression in melanoma cells implanted into mice.
Regulation (regulation) of Gene_expression (expression) of melanocortin-1 receptor associated with melanocortin 1 receptor and skin cancer
2) Confidence 0.62 Published 2002 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 12503610 Disease Relevance 0.41 Pain Relevance 0.64
Previous work showed that laboratory populations of beach and mainland mice differ by a fixed, single amino acid mutation that reduces Mc1r's signaling potential [18], but additional changes in Mc1r expression levels have not been ruled out as a contributor to the difference in pigmentation (see below).
Regulation (changes) of Gene_expression (expression) of Mc1r in pigmentation associated with melanocortin 1 receptor
3) Confidence 0.61 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.67
This suggests that regulation of MC1R gene expression is distinct from regulation of the other melanocyte-specific genes.
Regulation (regulation) of Gene_expression (expression) of MC1R gene in melanocyte
4) Confidence 0.58 Published 1996 Journal Somat. Cell Mol. Genet. Section Abstract Doc Link 8643993 Disease Relevance 0.21 Pain Relevance 0.09
Homologous regulation of melanocortin-1 receptor (MC1R) expression in melanoma tumor cells in vivo.
Regulation (regulation) of Gene_expression (expression) of MC1R associated with melanocortin 1 receptor, cancer and skin cancer
5) Confidence 0.45 Published 2002 Journal J. Recept. Signal Transduct. Res. Section Title Doc Link 12503610 Disease Relevance 0.39 Pain Relevance 0.53
Here, we report on the regulation of melanocortin-1 receptor (MC1R) expression in melanoma cells implanted into mice.
Regulation (regulation) of Gene_expression (expression) of MC1R associated with melanocortin 1 receptor and skin cancer
6) Confidence 0.45 Published 2002 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 12503610 Disease Relevance 0.41 Pain Relevance 0.64
There was no difference in Mc1r expression level among taxa or among body regions (analysis of variance, p > 0.05) and no correlation between Mc1r expression level and reflectance among taxa across body regions when all taxa were included (Figure 4; r = 0.45, R2 = 0.20, and p = 0.10).
Neg (no) Regulation (difference) of Gene_expression (expression) of Mc1r in body regions associated with melanocortin 1 receptor
7) Confidence 0.45 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.63
As a control, we compared patterns of Mc1r and Agouti expression in skin taken from the dorsum, a region that shows similar levels of pigmentation in beach and mainland subspecies and thus should show little difference in Mc1r and Agouti expression.
Regulation (patterns) of Gene_expression (expression) of Mc1r in dorsum associated with melanocortin 1 receptor
8) Confidence 0.39 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.49
As a control, we compared patterns of Mc1r and Agouti expression in skin taken from the dorsum, a region that shows similar levels of pigmentation in beach and mainland subspecies and thus should show little difference in Mc1r and Agouti expression.
Neg (little) Regulation (difference) of Gene_expression (expression) of Mc1r in dorsum associated with melanocortin 1 receptor
9) Confidence 0.39 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.51
Do hyporesponsive genetic variants of the melanocortin 1 receptor contribute to the etiology of multiple sclerosis?
Regulation (contribute) of Gene_expression (variants) of melanocortin 1 receptor associated with multiple sclerosis and melanocortin 1 receptor
10) Confidence 0.29 Published 2004 Journal Med. Hypotheses Section Title Doc Link 14729004 Disease Relevance 0.42 Pain Relevance 0.54
Dorsal skin showed no significant difference in Mc1r expression among the three taxa (analysis of variance, p = 0.96).
Neg (no) Regulation (difference) of Gene_expression (expression) of Mc1r in skin associated with melanocortin 1 receptor
11) Confidence 0.27 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.56
Although several melanin-based colour polymorphisms in wild birds depend on the expression of the melanocortin-1 receptor gene [MC1R; 8,26,48–51], a number of other genes coding for receptors of other different melanocortins are also involved in melanin production [51].
Regulation (depend) of Gene_expression (expression) of melanocortin-1 receptor gene associated with melanocortin 1 receptor
12) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954797 Disease Relevance 0.05 Pain Relevance 0.10

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