INT62424

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Context Info
Confidence 0.71
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 10
Disease Relevance 3.67
Pain Relevance 4.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Mc1r) signal transduction (Mc1r) plasma membrane (Mc1r)
signal transducer activity (Mc1r)
Anatomy Link Frequency
melanocyte 2
nerve 1
skin 1
midbrain 1
Mc1r (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 257 100.00 Very High Very High Very High
Central nervous system 3 99.68 Very High Very High Very High
Central grey 3 98.44 Very High Very High Very High
Inflammation 57 98.00 Very High Very High Very High
Spinal cord 12 97.08 Very High Very High Very High
midbrain 3 97.08 Very High Very High Very High
Pain 63 95.20 Very High Very High Very High
antagonist 19 92.28 High High
agonist 27 86.84 High High
Opioid 12 78.00 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 3 98.44 Very High Very High Very High
Injury 54 98.28 Very High Very High Very High
INFLAMMATION 60 98.00 Very High Very High Very High
Obesity 17 96.12 Very High Very High Very High
Pain 72 95.20 Very High Very High Very High
Sprains And Strains 33 93.60 High High
Nervous System Injury 6 93.08 High High
Targeted Disruption 25 91.20 High High
Microphthalmia 6 89.16 High High
Cancer 2 88.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following axotomy, no alteration in MC1R mRNA expression is seen in dorsal root ganglia and decreases in both MC2R and MC3R, but MC4R mRNA increases following axotomy [48], perhaps suggesting a greater role for MC4R than MC1R in nerve injury.
Transcription (expression) of MC1R in nerve associated with nervous system injury and melanocortin 1 receptor
1) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2938350 Disease Relevance 1.09 Pain Relevance 1.08
To quantify Mc1r and Agouti transcript levels in wild type and melanic mice from New Hampshire, we used quantitative real-time PCR to detect Mc1r and Agouti mRNA in the skin of 4-day-old (P4) pups, a time when Agouti expression is high [52].
Transcription (detect) of Mc1r in skin associated with melanocortin 1 receptor
2) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713407 Disease Relevance 0 Pain Relevance 0.36
A point mutation resulting in the replacement of glutamate with lysine was present in at least one allele of the MC1R gene in all melanic birds and was absent in all yellow morph birds.
Transcription (allele) of MC1R gene
3) Confidence 0.69 Published 2001 Journal Curr. Biol. Section Body Doc Link 11369199 Disease Relevance 0 Pain Relevance 0
MC1R mRNA and protein are also expressed in the central nervous system, in the periaqueductal gray matter of the midbrain [18], an area known to be involved in pain modulation [19].
Transcription (expressed) of MC1R in midbrain associated with pain, melanocortin 1 receptor, midbrain, central nervous system and central grey
4) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2938350 Disease Relevance 0.42 Pain Relevance 1.52
A number of additional physiological roles have been ascribed to MC1R, in particular in mediating the established anti-inflammatory activity of ?
Transcription (ascribed) of MC1R associated with inflammation and melanocortin 1 receptor
5) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2938350 Disease Relevance 0.52 Pain Relevance 0.95
In contrast to the results with the melanocyte-specific genes mentioned above, transcripts for the melanocortin 1 receptor gene (MC1R) were present in the monochromosomal unpigmented microcell hybrid (although absent in the whole-cell hybrids).
Transcription (transcripts) of MC1R in melanocyte associated with melanocortin 1 receptor
6) Confidence 0.67 Published 1996 Journal Somat. Cell Mol. Genet. Section Abstract Doc Link 8643993 Disease Relevance 0.23 Pain Relevance 0.10
In contrast to the results with the melanocyte-specific genes mentioned above, transcripts for the melanocortin 1 receptor gene (MC1R) were present in the monochromosomal unpigmented microcell hybrid (although absent in the whole-cell hybrids).
Transcription (transcripts) of melanocortin 1 receptor gene in melanocyte associated with melanocortin 1 receptor
7) Confidence 0.67 Published 1996 Journal Somat. Cell Mol. Genet. Section Abstract Doc Link 8643993 Disease Relevance 0.23 Pain Relevance 0.10
The key findings included 1) that the coat color phenotype in the lethal yellow (A(Y)/a) mouse is due to antagonism of the melanocortin-1 receptor (MC1R) by the agouti gene product; 2) the MC3R and MC4R are expressed in CNS centers involved in energy homeostasis, and 3) the combined results of pharmacological studies showing that agouti is an antagonist of the MC4R and transgenic studies showing that inhibition or loss of the MC4R recapitulate the lethal yellow phenotype.
Transcription (antagonism) of MC1R associated with targeted disruption, melanocortin 1 receptor and antagonist
8) Confidence 0.63 Published 2002 Journal Neuropeptides Section Abstract Doc Link 12359499 Disease Relevance 0.30 Pain Relevance 0.15
The key findings included 1) that the coat color phenotype in the lethal yellow (A(Y)/a) mouse is due to antagonism of the melanocortin-1 receptor (MC1R) by the agouti gene product; 2) the MC3R and MC4R are expressed in CNS centers involved in energy homeostasis, and 3) the combined results of pharmacological studies showing that agouti is an antagonist of the MC4R and transgenic studies showing that inhibition or loss of the MC4R recapitulate the lethal yellow phenotype.
Transcription (antagonism) of melanocortin-1 receptor associated with targeted disruption, melanocortin 1 receptor and antagonist
9) Confidence 0.63 Published 2002 Journal Neuropeptides Section Abstract Doc Link 12359499 Disease Relevance 0.30 Pain Relevance 0.15
We show that incubation of cells with MSH/isobutylmethylxanthine (IBMX) resulted in strong melanogenic and morphologic responses in high metastatic hybrids compared to parental cells and the low metastatic hybrid, and that high metastatic hybrids exhibit increased mRNA expression for MC1-R accompanied by increased 125I-alphaMSH binding.
Transcription (expression) of MC1-R
10) Confidence 0.41 Published 1999 Journal Pigment Cell Res. Section Abstract Doc Link 10614575 Disease Relevance 0.58 Pain Relevance 0.14

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