INT62425

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Context Info
Confidence 0.29
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.44
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Tyrp1) oxidoreductase activity (Tyrp1)
Anatomy Link Frequency
plasma 4
neurons 2
fibroblast 2
nociceptor 2
afferent neuron 2
Tyrp1 (Mus musculus)
Pain Link Frequency Relevance Heat
TRP channel 21 100.00 Very High Very High Very High
Spinal cord 12 99.00 Very High Very High Very High
nociceptor 57 97.76 Very High Very High Very High
Calcitonin gene-related peptide 66 93.04 High High
unmyelinated 12 88.96 High High
melanocortin 1 receptor 1 74.56 Quite High
Lasting pain 3 72.96 Quite High
ASIC 3 70.56 Quite High
c fibre 51 70.40 Quite High
withdrawal 3 70.08 Quite High
Disease Link Frequency Relevance Heat
Microphthalmia 3 99.48 Very High Very High Very High
Bacterial Respiratory Disease 5 99.04 Very High Very High Very High
Stress 86 97.16 Very High Very High Very High
Infection 11 95.32 Very High Very High Very High
Congenital Anomalies 4 86.96 High High
Pain 3 72.96 Quite High
Targeted Disruption 48 67.60 Quite High
Skin Cancer 1 62.80 Quite High
INFLAMMATION 14 61.12 Quite High
Depression 22 51.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Marked increase in plasma Trp and altered plasma Trp metabolite levels in Tdo-/- adult mice
Regulation (altered) of Gene_expression (levels) of Trp in plasma
1) Confidence 0.29 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.09 Pain Relevance 0
Since the only fibroblast chromosome detected in the unpigmented microcell hybrid was mouse chromosome 1, these results also suggest that the extinguisher locus affecting the expression of the tyrosinase, TRP-1, TRP-2, and microphthalmia genes in hybrid cells is located on that mouse chromosome (or on a fragment of another chromosome present in the unpigmented monochromosomal microcell hybrid but undetected in our analyses).
Regulation (affecting) of Gene_expression (expression) of TRP-1 in fibroblast associated with microphthalmia
2) Confidence 0.28 Published 1996 Journal Somat. Cell Mol. Genet. Section Abstract Doc Link 8643993 Disease Relevance 0.33 Pain Relevance 0.07
Marked increase in plasma Trp and altered plasma Trp metabolite levels in Tdo-/- adult mice
Regulation (altered) of Gene_expression (levels) of Trp in plasma
3) Confidence 0.21 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.09 Pain Relevance 0
Surprisingly, GCs which primarily activate the TDO-driven Trp catabolism [22], [27] don't have the leading role for Trp depletion or for the loss of the antibacterial defense in our model of repeated stress.
Regulation (role) of Gene_expression (depletion) of Trp associated with stress and bacterial respiratory disease
4) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.80 Pain Relevance 0.12
The expression of TRP channels is selectively altered in mutant DRG neurons.
Regulation (altered) of Gene_expression (expression) of TRP in neurons associated with trp channel
5) Confidence 0.09 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.36
The effects of the ret mutation on TRP channel expression reveal the regulation of subsets of genes expressed in nociceptor populations.
Regulation (effects) of Gene_expression (expression) of TRP in nociceptor associated with trp channel and nociceptor
6) Confidence 0.09 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.53
Thus, GFRalpha2 mutants require more analysis to provide details regarding the alterations in afferent neuron physiology and in TRP channel expression that may underlie the behavioural phenotype.
Regulation (alterations) of Gene_expression (expression) of TRP in afferent neuron associated with trp channel
7) Confidence 0.06 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.14 Pain Relevance 0.33

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