INT62426

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2011
Negated 9
Speculated 5
Reported most in Abstract
Documents 127
Total Number 135
Disease Relevance 42.99
Pain Relevance 48.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Mc1r) signal transduction (Mc1r) plasma membrane (Mc1r)
signal transducer activity (Mc1r)
Anatomy Link Frequency
melanocyte 21
T cells 15
epidermis 12
pigmentation 6
macrophage 2
Mc1r (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 2846 100.00 Very High Very High Very High
Neuropathic pain 105 100.00 Very High Very High Very High
antagonist 152 99.96 Very High Very High Very High
imagery 45 99.96 Very High Very High Very High
agonist 387 99.92 Very High Very High Very High
Central nervous system 30 99.68 Very High Very High Very High
Inflammation 1107 99.56 Very High Very High Very High
Multiple sclerosis 10 99.24 Very High Very High Very High
Central grey 15 98.44 Very High Very High Very High
tolerance 244 98.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 330 100.00 Very High Very High Very High
Skin Cancer 1819 99.90 Very High Very High Very High
Amelanotic Melanoma 1 99.84 Very High Very High Very High
Hypersensitivity 387 99.72 Very High Very High Very High
INFLAMMATION 1208 99.56 Very High Very High Very High
Targeted Disruption 156 99.52 Very High Very High Very High
Cancer 1149 99.48 Very High Very High Very High
Melanoma 34 99.44 Very High Very High Very High
Demyelinating Disease 10 99.24 Very High Very High Very High
Sarcoma 2 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surprisingly, many of the Mc1r-dependent genes are expressed in cells other than melanocytes, even though Mc1r expression in the skin is confined almost exclusively to epidermal melanocytes.
Gene_expression (expression) of Mc1r in melanocytes associated with melanocortin 1 receptor
1) Confidence 0.78 Published 2006 Journal Pigment Cell Res. Section Abstract Doc Link 16704453 Disease Relevance 0.06 Pain Relevance 0.60
The melanocortin 1 receptor (Mc1r) plays a central role in cutaneous biology, but is expressed at very low levels by a small fraction of cells in the skin.
Gene_expression (expressed) of Mc1r in skin associated with melanocortin 1 receptor
2) Confidence 0.78 Published 2006 Journal Pigment Cell Res. Section Abstract Doc Link 16704453 Disease Relevance 0.09 Pain Relevance 0.35
The melanocortin 1 receptor (Mc1r) plays a central role in cutaneous biology, but is expressed at very low levels by a small fraction of cells in the skin.
Gene_expression (expressed) of melanocortin 1 receptor in skin associated with melanocortin 1 receptor
3) Confidence 0.78 Published 2006 Journal Pigment Cell Res. Section Abstract Doc Link 16704453 Disease Relevance 0.09 Pain Relevance 0.35
After implantation into mice and exposure to the natural MC1R agonist alpha-melanocyte-stimulating hormone (alpha-MSH), cell-surface MC1R expression was evaluated by competition binding experiments in tumor membrane preparations.
Gene_expression (expression) of MC1R in melanocyte associated with melanocortin 1 receptor, cancer and agonist
4) Confidence 0.78 Published 2002 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 12503610 Disease Relevance 0.42 Pain Relevance 0.82
Here, we report on the regulation of melanocortin-1 receptor (MC1R) expression in melanoma cells implanted into mice.
Gene_expression (expression) of MC1R associated with melanocortin 1 receptor and skin cancer
5) Confidence 0.78 Published 2002 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 12503610 Disease Relevance 0.41 Pain Relevance 0.64
Homologous regulation of melanocortin-1 receptor (MC1R) expression in melanoma tumor cells in vivo.
Gene_expression (expression) of melanocortin-1 receptor associated with melanocortin 1 receptor, cancer and skin cancer
6) Confidence 0.78 Published 2002 Journal J. Recept. Signal Transduct. Res. Section Title Doc Link 12503610 Disease Relevance 0.39 Pain Relevance 0.53
Homologous regulation of melanocortin-1 receptor (MC1R) expression in melanoma tumor cells in vivo.
Gene_expression (expression) of MC1R associated with melanocortin 1 receptor, cancer and skin cancer
7) Confidence 0.78 Published 2002 Journal J. Recept. Signal Transduct. Res. Section Title Doc Link 12503610 Disease Relevance 0.39 Pain Relevance 0.53
Here, we report on the regulation of melanocortin-1 receptor (MC1R) expression in melanoma cells implanted into mice.
Gene_expression (expression) of melanocortin-1 receptor associated with melanocortin 1 receptor and skin cancer
8) Confidence 0.78 Published 2002 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 12503610 Disease Relevance 0.41 Pain Relevance 0.64
The finding that melanocortin-1 receptor (MC1R) is overexpressed in isolated melanoma cells and melanoma tissues led to the radiolabeling of several alpha-melanocyte-stimulating hormone (alpha-MSH) analogs for early detection and treatment of melanoma.
Gene_expression (overexpressed) of MC1R in melanocyte associated with melanocortin 1 receptor and skin cancer
9) Confidence 0.77 Published 2008 Journal Nucl. Med. Biol. Section Abstract Doc Link 18158948 Disease Relevance 0.83 Pain Relevance 0.20
The finding that melanocortin-1 receptor (MC1R) is overexpressed in isolated melanoma cells and melanoma tissues led to the radiolabeling of several alpha-melanocyte-stimulating hormone (alpha-MSH) analogs for early detection and treatment of melanoma.
Gene_expression (overexpressed) of melanocortin-1 receptor in melanocyte associated with melanocortin 1 receptor and skin cancer
10) Confidence 0.77 Published 2008 Journal Nucl. Med. Biol. Section Abstract Doc Link 18158948 Disease Relevance 0.84 Pain Relevance 0.20
Indeed, previous work from our group and others indicates that while Mc1r expression is confined mainly to melanocytes, Mc1r deficiency leads to substantial changes in gene expression throughout the skin and suggests that melanocytes influence the behavior of surrounding cells via paracrine mechanisms.
Gene_expression (expression) of Mc1r in skin
11) Confidence 0.77 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.44 Pain Relevance 0.45
MC1R is a G protein-coupled receptor expressed in melanocytes and elsewhere and mice lacking MC1R have yellow hair, whilst humans with variant MC1R protein have red hair.
Gene_expression (expressed) of MC1R in hair
12) Confidence 0.77 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2938350 Disease Relevance 0.60 Pain Relevance 0.65
There was no difference in Mc1r expression level among taxa or among body regions (analysis of variance, p > 0.05) and no correlation between Mc1r expression level and reflectance among taxa across body regions when all taxa were included (Figure 4; r = 0.45, R2 = 0.20, and p = 0.10).
Gene_expression (expression) of Mc1r in body regions associated with melanocortin 1 receptor
13) Confidence 0.77 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.63
There was no difference in Mc1r expression level among taxa or among body regions (analysis of variance, p > 0.05) and no correlation between Mc1r expression level and reflectance among taxa across body regions when all taxa were included (Figure 4; r = 0.45, R2 = 0.20, and p = 0.10).
Gene_expression (expression) of Mc1r in body regions associated with melanocortin 1 receptor
14) Confidence 0.77 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.57
Previous work showed that laboratory populations of beach and mainland mice differ by a fixed, single amino acid mutation that reduces Mc1r's signaling potential [18], but additional changes in Mc1r expression levels have not been ruled out as a contributor to the difference in pigmentation (see below).
Gene_expression (expression) of Mc1r in pigmentation associated with melanocortin 1 receptor
15) Confidence 0.77 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.66
We also compared levels of Mc1r expression between the three taxa for four body regions (rostrum, cheek, eyebrow, and earbase) that show large differences in pigmentation between beach and mainland mice.
Gene_expression (expression) of Mc1r in cheek associated with melanocortin 1 receptor
16) Confidence 0.77 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.67
Dorsal skin showed no significant difference in Mc1r expression among the three taxa (analysis of variance, p = 0.96).
Gene_expression (expression) of Mc1r in skin associated with melanocortin 1 receptor
17) Confidence 0.77 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.56
Radiolabeled alpha-melanocyte stimulating hormone (a-MSH) analogues have been used to define the expression, affinity and function of the melanocortin-1 receptor (MC1-R).
Gene_expression (expression) of melanocortin-1 receptor in melanocyte associated with melanocortin 1 receptor
18) Confidence 0.76 Published 2010 Journal G Ital Dermatol Venereol Section Abstract Doc Link 20467398 Disease Relevance 0.25 Pain Relevance 0.18
Radiolabeled alpha-melanocyte stimulating hormone (a-MSH) analogues have been used to define the expression, affinity and function of the melanocortin-1 receptor (MC1-R).
Gene_expression (expression) of MC1-R in melanocyte associated with melanocortin 1 receptor
19) Confidence 0.76 Published 2010 Journal G Ital Dermatol Venereol Section Abstract Doc Link 20467398 Disease Relevance 0.25 Pain Relevance 0.18
This study demonstrates that 64Cu-DOTA-NAPamide is a promising molecular probe for alpha-MSH receptor positive melanoma PET imaging as well as MC1R expression imaging in living mice.
Gene_expression (expression) of MC1R associated with skin cancer and imagery
20) Confidence 0.76 Published 2007 Journal Bioconjug. Chem. Section Abstract Doc Link 17348700 Disease Relevance 1.05 Pain Relevance 0.26

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