INT62441

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 56
Total Number 57
Disease Relevance 21.01
Pain Relevance 12.93

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transport (ABCC1) small molecule metabolic process (ABCC1) Golgi apparatus (ABCC1)
nucleolus (ABCC1) ATPase activity (ABCC1) plasma membrane (ABCC1)
Anatomy Link Frequency
liver 4
T98G 2
skeletal muscle myoblast 2
skeletal muscle 2
blood 2
ABCC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 26 100.00 Very High Very High Very High
cINOD 126 99.84 Very High Very High Very High
COX2 6 99.14 Very High Very High Very High
Glutamate 423 99.04 Very High Very High Very High
methotrexate 26 98.96 Very High Very High Very High
qutenza 39 98.68 Very High Very High Very High
Chronic pancreatitis 2 98.60 Very High Very High Very High
COX-2 inhibitor 55 98.40 Very High Very High Very High
rheumatoid arthritis 24 97.72 Very High Very High Very High
Nicotine 240 96.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Breast Cancer 79 100.00 Very High Very High Very High
Biliary Liver Cirrhosis 24 100.00 Very High Very High Very High
Cancer 855 99.98 Very High Very High Very High
Lung Cancer 204 99.60 Very High Very High Very High
Small Cell Lung Cancer 35 99.54 Very High Very High Very High
INFLAMMATION 103 99.12 Very High Very High Very High
Non-small-cell Lung Cancer 104 98.96 Very High Very High Very High
Pancreatitis 3 98.60 Very High Very High Very High
Targeted Disruption 217 98.56 Very High Very High Very High
Colon Cancer 43 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NCI H460 cells expressed MRP-1 protein (by Western blot) and also the toxicity of doxorubicin (a substrate of MRP-1) could be potentiated in this line using non-toxic concentrations of the MRP-1 substrate/inhibitor sulindac.
Gene_expression (expressed) of MRP-1 in H460
1) Confidence 0.78 Published 2004 Journal Anticancer Res. Section Body Doc Link 15152944 Disease Relevance 0.09 Pain Relevance 0
Furthermore, we show that expression of human OATP2B1 in human skeletal muscle myoblast cells by adenoviral vectors increases intracellular accumulation and toxicity of statins and such effects were abrogated when cells overexpressed MRP1.
Gene_expression (overexpressed) of MRP1 in skeletal muscle myoblast
2) Confidence 0.75 Published 2010 Journal Circ. Res. Section Body Doc Link 19940267 Disease Relevance 0.06 Pain Relevance 0
The objective was to evaluate the expression of the multidrug resistance P-glycoprotein (P-gp) in peripheral blood lymphocytes (PBL) of patients with rheumatoid arthritis (RA).
Gene_expression (expression) of multidrug resistance in blood associated with rheumatoid arthritis
3) Confidence 0.75 Published 1996 Journal Br. J. Rheumatol. Section Abstract Doc Link 8646432 Disease Relevance 0.60 Pain Relevance 0.33
Moreover, it has been suggested that COX-2 inhibitors may contribute to maintain high levels of chemotherapeutics in tumor tissues by preventing the overexpression of the multidrug resistance protein MDR1/P-gp.
Gene_expression (overexpression) of multidrug resistance protein MDR1 associated with cancer and cox-2 inhibitor
4) Confidence 0.75 Published 2005 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 15850674 Disease Relevance 0.88 Pain Relevance 0.58
Here, we studied the effect of various NSAIDs on MTX transport in membrane vesicles isolated from cells overexpressing the proximal tubular apical efflux transporters human multidrug resistance protein (MRP) 2/ABCC2 and MRP4/ABCC4.
Gene_expression (overexpressing) of MRP in proximal associated with cinod and methotrexate
5) Confidence 0.75 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17005917 Disease Relevance 0.32 Pain Relevance 0.91
METHODS AND RESULTS: We demonstrate that the uptake transporter OATP2B1 (human organic anion transporting polypeptide 2B1) and the efflux transporters, multidrug resistance-associated protein (MRP)1, MRP4, and MRP5 are expressed on the sarcolemmal membrane of human skeletal muscle fibers and that atorvastatin and rosuvastatin are substrates of these transporters when assessed using a heterologous expression system.
Gene_expression (expressed) of MRP in skeletal muscle
6) Confidence 0.75 Published 2010 Journal Circ. Res. Section Body Doc Link 19940267 Disease Relevance 0.09 Pain Relevance 0
The present study was conducted to investigate the expression of hepatobiliary efflux transporters in livers from patients after toxic acetaminophen (APAP) ingestion, with livers from patients with primary biliary cirrhosis (PBC) serving as positive controls. mRNA and protein expression of multidrug resistance-associated protein (MRP) 1-6, multidrug resistance protein (MDR) 1-3/P-glycoprotein (P-gp), and breast cancer resistance protein (BCRP) in normal (n = 6), APAP overdose (n = 5), and PBC (n = 6) human liver samples were determined by branched DNA and Western blot analysis, respectively.
Gene_expression (expression) of MRP in livers associated with biliary liver cirrhosis, paracetamol, breast cancer and overdose
7) Confidence 0.75 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17627974 Disease Relevance 0.73 Pain Relevance 0.42
Furthermore, the expression of a variety of drug transporters (ABCB1, ABCG2, ABCC1-5) as well as the human transferrin receptor was demonstrated on the mRNA level.
Gene_expression (expression) of ABCC1-5
8) Confidence 0.70 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 19013850 Disease Relevance 0 Pain Relevance 0.14
Suppression of ROS formation by antioxidant N-acetylcysteine (NAC) downregulated the induction of MRP1 and MRP3 expression.
Gene_expression (expression) of MRP1
9) Confidence 0.69 Published 2002 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11820781 Disease Relevance 0.65 Pain Relevance 0.38
In this study, we reported that among the six members of the multidrug resistance protein gene (MRP1 to MRP6) family which encode membrane transporters for a diverse group of antitumor agents, expression of MRP1 and MRP3 but not the others in human colorectal cancer cell lines was induced by sulindac.
Gene_expression (expression) of MRP1 associated with colon cancer
10) Confidence 0.69 Published 2002 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11820781 Disease Relevance 0.64 Pain Relevance 0.46
METHODS AND RESULTS: We demonstrate that the uptake transporter OATP2B1 (human organic anion transporting polypeptide 2B1) and the efflux transporters, multidrug resistance-associated protein (MRP)1, MRP4, and MRP5 are expressed on the sarcolemmal membrane of human skeletal muscle fibers and that atorvastatin and rosuvastatin are substrates of these transporters when assessed using a heterologous expression system.
Gene_expression (expressed) of resistance-associated protein in skeletal muscle
11) Confidence 0.66 Published 2010 Journal Circ. Res. Section Body Doc Link 19940267 Disease Relevance 0.09 Pain Relevance 0
Also, capsaicin, daidzein, piperine and sesamin increased significantly the mRNA expression of MRP1 or MRP3.
Gene_expression (expression) of MRP1 associated with qutenza
12) Confidence 0.65 Published 2010 Journal Biol. Pharm. Bull. Section Abstract Doc Link 20118549 Disease Relevance 0 Pain Relevance 0.31
In an in vitro model of differentiated, primary human skeletal muscle myoblast cells, we demonstrate basal membrane expression and drug efflux activity of MRP1, which contributes to reducing intracellular statin accumulation.
Gene_expression (expression) of MRP1 in skeletal muscle myoblast
13) Confidence 0.65 Published 2010 Journal Circ. Res. Section Body Doc Link 19940267 Disease Relevance 0.07 Pain Relevance 0
Caco-2 [36] or MDR1-MDCK (Madin Darby canine kidney cells transfected with the human multidrug resistance MDR1 gene) [37] cell monolayers were grown to confluence on collagen-coated, microporous, polycarbonate membranes in 12-well microtitre plates.
Gene_expression (transfected) of multidrug resistance in MDCK
14) Confidence 0.65 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3006138 Disease Relevance 0 Pain Relevance 0
Herein we review general mechanisms of drug resistance, including multidrug resistance by P-glycoprotein and the multidrug resistance protein family in association with specific agents and their metabolism, emergence of refractory tumors associated with multiple resistance mechanisms, and resistance factors unique to host-tumor-drug interactions.
Gene_expression (resistance) of multidrug resistance associated with cancer
15) Confidence 0.65 Published 2007 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 17993229 Disease Relevance 1.62 Pain Relevance 0
In addition to GCS, which modulates intracellular glutathione levels, other Nrf2 downstream genes, including GST, UDP-glucuronosyl transferase, and multidrug resistance proteins, also contribute to the Nrf2-mediated protection against arsenic toxicity (Hayashi et al. 2003; Kobayashi and Yamamoto 2006; Maher et al. 2005; Vernhet et al. 2001; Xu et al. 2005; Zhang 2006).
Gene_expression (proteins) of multidrug resistance associated with toxicity
16) Confidence 0.65 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0.35 Pain Relevance 0
Many transporters such as multidrug resistance proteins and p-glycoprotein are important in uptake and removal of xenobiotics (Hayashi et al. 2003; Maher et al. 2005; Vernhet et al. 2001; Xu et al. 2005).
Gene_expression (proteins) of multidrug resistance
17) Confidence 0.65 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0 Pain Relevance 0
In contrast, a multidrug resistance (MDR) phenotype due to expression of the multidrug resistance-associated protein (MRP) is most prominent in T98G cells and is amenable to modulation by indomethacin, suggesting that inhibition of MRP is at least in partly responsible for the potentiation of doxorubicin and vincristine cytotoxicity by NSAID.
Gene_expression (expression) of MRP in T98G associated with vincristine and cinod
18) Confidence 0.65 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10364464 Disease Relevance 0.27 Pain Relevance 1.06
RESULTS: Sulindac was shown to significantly potentiate the tumour growth inhibitor activity of doxorubicin in this MRP-1-overexpressing human tumour xenograft model.
Gene_expression (overexpressing) of MRP-1-overexpressing
19) Confidence 0.59 Published 2004 Journal Anticancer Res. Section Body Doc Link 15152944 Disease Relevance 0.07 Pain Relevance 0
However, in the HL60/ADR and COR L23R cell lines, in which multidrug resistance is due to overexpression of the multidrug resistance-associated protein MRP, a significant increase in cytotoxicity was observed in the presence of the active NSAIDs.
Gene_expression (overexpression) of multidrug resistance associated with cinod
20) Confidence 0.58 Published 1998 Journal Eur. J. Cancer Section Abstract Doc Link 9849488 Disease Relevance 0.32 Pain Relevance 0.60

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