INT62448

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Context Info
Confidence 0.59
First Reported 1995
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.36
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2, Crh) extracellular region (Il2, Crh) response to stress (Crh)
cytoplasm (Crh)
Il2 (Rattus norvegicus)
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 9 99.42 Very High Very High Very High
narcan 15 99.06 Very High Very High Very High
opiate 3 89.32 High High
dexamethasone 12 81.28 Quite High
Calcium channel 3 70.76 Quite High
Disease Link Frequency Relevance Heat
Stress 6 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-2 significantly stimulated CRF release at concentrations of 10(-13) and 10(-14) M, whereas increasing the concentration to 10(-12) to 10(-10) M did not produce significant release of CRF.
IL-2 Positive_regulation (stimulated) of CRF release
1) Confidence 0.59 Published 1995 Journal Neuroimmunomodulation Section Abstract Doc Link 8646567 Disease Relevance 0.16 Pain Relevance 0.11
At concentrations of 5 x 10(-6) and 10(-5) M, it produced a marked increase in CRF release; however, the simultaneous exposure of MBHs to each of these concentrations of NAL plus IL-2 caused a dose-dependent decrease in IL-2-induced CRF release, suggesting that beta-endorphin or other opioid peptides may play a role in IL-2-induced CRF release.
IL-2-induced Positive_regulation (induced) of CRF release associated with narcan and opioid
2) Confidence 0.43 Published 1995 Journal Neuroimmunomodulation Section Abstract Doc Link 8646567 Disease Relevance 0.13 Pain Relevance 0.60
At concentrations of 5 x 10(-6) and 10(-5) M, it produced a marked increase in CRF release; however, the simultaneous exposure of MBHs to each of these concentrations of NAL plus IL-2 caused a dose-dependent decrease in IL-2-induced CRF release, suggesting that beta-endorphin or other opioid peptides may play a role in IL-2-induced CRF release.
IL-2-induced Positive_regulation (induced) of CRF release associated with narcan and opioid
3) Confidence 0.43 Published 1995 Journal Neuroimmunomodulation Section Abstract Doc Link 8646567 Disease Relevance 0.07 Pain Relevance 0.59

General Comments

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