INT62450

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Context Info
Confidence 0.43
First Reported 1995
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 5
Disease Relevance 0.59
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2, Crh) extracellular region (Il2, Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
melanocyte 2
Il2 (Rattus norvegicus)
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 25 99.30 Very High Very High Very High
Opioid 15 98.32 Very High Very High Very High
opiate 5 92.72 High High
Calcium channel 5 92.60 High High
dexamethasone 20 92.20 High High
Disease Link Frequency Relevance Heat
Stress 10 99.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibitor of cyclooxygenase, indomethacin (IND), also blocked IL-2-induced CRF release just as it has previously been shown to block IL-1- and IL-6-induced CRF release.
IL-2-induced Positive_regulation (induced) of Localization (release) of CRF release
1) Confidence 0.43 Published 1995 Journal Neuroimmunomodulation Section Abstract Doc Link 8646567 Disease Relevance 0.05 Pain Relevance 0.51
At concentrations of 5 x 10(-6) and 10(-5) M, it produced a marked increase in CRF release; however, the simultaneous exposure of MBHs to each of these concentrations of NAL plus IL-2 caused a dose-dependent decrease in IL-2-induced CRF release, suggesting that beta-endorphin or other opioid peptides may play a role in IL-2-induced CRF release.
IL-2-induced Positive_regulation (induced) of Localization (decrease) of CRF release associated with narcan and opioid
2) Confidence 0.43 Published 1995 Journal Neuroimmunomodulation Section Abstract Doc Link 8646567 Disease Relevance 0.13 Pain Relevance 0.60
As has been previously shown for IL-1 and IL-6, IL-2-induced CRF release was blocked by alpha-melanocyte-stimulating hormone (alpha-MSH), which at high concentrations also reduced basal CRF release.
IL-2-induced Positive_regulation (induced) of Localization (release) of CRF release in melanocyte
3) Confidence 0.43 Published 1995 Journal Neuroimmunomodulation Section Abstract Doc Link 8646567 Disease Relevance 0.07 Pain Relevance 0.58
Since the release of luteinizing-hormone-releasing hormone (LHRH) is modified by stress, we evaluated the action of LHRH on CRF release and the release induced by IL-2.
IL-2 Positive_regulation (induced) of Localization (release) of CRF release associated with stress
4) Confidence 0.43 Published 1995 Journal Neuroimmunomodulation Section Abstract Doc Link 8646567 Disease Relevance 0.17 Pain Relevance 0.45
Although LHRH failed to alter basal CRF release, except for a slight decrease at 10(-7) M, it completely blocked IL-2-induced CRF release at this concentration.
IL-2-induced Positive_regulation (induced) of Localization (release) of CRF release
5) Confidence 0.43 Published 1995 Journal Neuroimmunomodulation Section Abstract Doc Link 8646567 Disease Relevance 0.16 Pain Relevance 0.50

General Comments

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