INT62452

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Context Info
Confidence 0.61
First Reported 1995
Last Reported 2009
Negated 3
Speculated 6
Reported most in Abstract
Documents 14
Total Number 20
Disease Relevance 12.11
Pain Relevance 7.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2)
Anatomy Link Frequency
brain 5
spinal cord 1
microglia 1
spinal 1
myocytes 1
Il2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain threshold 2 99.84 Very High Very High Very High
Eae 240 99.76 Very High Very High Very High
Locus ceruleus 6 99.48 Very High Very High Very High
qutenza 1 98.56 Very High Very High Very High
cerebral cortex 90 98.52 Very High Very High Very High
depression 50 98.24 Very High Very High Very High
substance P 2 98.24 Very High Very High Very High
Intracerebroventricular 13 98.16 Very High Very High Very High
dexamethasone 4 97.78 Very High Very High Very High
Neuropathic pain 3 97.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 14 99.84 Very High Very High Very High
Anxiety Disorder 850 99.68 Very High Very High Very High
Endometriosis (extended) 100 99.04 Very High Very High Very High
Nociception 9 98.96 Very High Very High Very High
Depression 60 98.24 Very High Very High Very High
Disease 7 97.66 Very High Very High Very High
Neuropathic Pain 3 97.64 Very High Very High Very High
Ganglion Cysts 6 97.04 Very High Very High Very High
Urological Neuroanatomy 3 96.76 Very High Very High Very High
Syndrome 35 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As IL-2 in the brain is involved in emotional behavior and its effects are area-dependent [3,23], it was of interest to examine the effects of dioscorea on IL-2 levels in the brain of menopausal animals.
Spec (examine) Regulation (effects) of IL-2 in brain associated with endometriosis (extended)
1) Confidence 0.61 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 1.07 Pain Relevance 0.14
These groups were used to examine the effect of dioscorea on behavior and IL-2 levels.
Spec (examine) Regulation (effect) of IL-2
2) Confidence 0.61 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 0.38 Pain Relevance 0
The present study was designed to investigate effects of IL-2 on the physiological properties of capsaicin-sensitive small dorsal root ganglion (DRG) neurons, which are predominantly responsible for nociceptive transmission from the periphery to the spinal cord.
Spec (investigate) Regulation (effects) of IL-2 in DRG associated with nociception, ganglion cysts, dorsal root ganglion, qutenza and spinal cord
3) Confidence 0.45 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12527482 Disease Relevance 0.52 Pain Relevance 0.67
The present data suggest that IL-2 in the brain could play a role in postmenopausal anxiety and could be involved in the mechanisms by which dioscorea decreases anxiety levels in HA OVX rats.
Regulation (role) of IL-2 in brain associated with anxiety disorder
4) Confidence 0.45 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 1.40 Pain Relevance 0.15
[Effect of interleukin-2 on intracellular calcium transients in rat ventricular myocytes].
Regulation ([Effect) of interleukin-2 in myocytes
5) Confidence 0.45 Published 2001 Journal Sheng Li Xue Bao Section Title Doc Link 11930219 Disease Relevance 0.06 Pain Relevance 0.40
Effects of intra-hippocampal injection of interleukin-2 on pain threshold and formaldehyde-induced substance P-like immunoreactivity in periaqueductal gray and spinal cord.
Regulation (Effects) of interleukin-2 in spinal cord associated with pain threshold, central grey, spinal cord and substance p
6) Confidence 0.44 Published 1999 Journal Zhongguo Yao Li Xue Bao Section Title Doc Link 11245094 Disease Relevance 0.20 Pain Relevance 0.47
The serum proinflammatory cytokines IL-1, IL-6 and TNF-a and the serum globulin fraction were elevated in AID rats, parameters which were more or less normalised by melanin treatment in contrast to the reduced serum levels of IL-2 which were not affected.
Neg (not) Regulation (affected) of IL-2 associated with disease and cytokine
7) Confidence 0.39 Published 1998 Journal Arzneimittelforschung Section Abstract Doc Link 9706378 Disease Relevance 0.98 Pain Relevance 0.41
As in the case of IL-1 and IL-2, dexamethasone (DEX), the highly active synthetic glucocorticoid, although not altering basal CRF release, completely blocked the response to IL-2.
Regulation (response) of IL-2 associated with dexamethasone
8) Confidence 0.38 Published 1995 Journal Neuroimmunomodulation Section Abstract Doc Link 8646567 Disease Relevance 0.06 Pain Relevance 0.53
This study was to examine the effects of microinjection of human recombinant interleukin 2 (IL-2) into locus coeruleus (LC) on spinal nociception.
Spec (examine) Regulation (effects) of interleukin 2 in spinal associated with nociception and locus ceruleus
9) Confidence 0.29 Published 2000 Journal Neuropeptides Section Abstract Doc Link 11021983 Disease Relevance 0.26 Pain Relevance 0.31
The aim of the present study was to investigate the effects of dioscorea (wild yam), a Chinese medicine, on emotional behavior and IL-2 levels in the brain of ovariectomized (OVX) rats.


Spec (investigate) Regulation (effects) of IL-2 in brain
10) Confidence 0.27 Published 2007 Journal Ann Gen Psychiatry Section Abstract Doc Link PMC1971263 Disease Relevance 0.64 Pain Relevance 0.07
Furthermore, the effects of dioscorea on behavior and IL-2 levels were dependent on the anxiety levels of the OVX rats and had task-dependent behavioral consequences, indicating that cytokine responses to treatment might be involved in the individual differences in anxiety levels.


Regulation (effects) of IL-2 associated with anxiety disorder and cytokine
11) Confidence 0.27 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 1.16 Pain Relevance 0.37
Furthermore, the effects of dioscorea on behavior and IL-2 levels were dependent on the anxiety levels of the OVX rats and had task-dependent behavioral consequences, indicating that cytokine responses to treatment might be involved in the individual differences in anxiety levels.


Regulation (dependent) of IL-2 associated with anxiety disorder and cytokine
12) Confidence 0.27 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 1.15 Pain Relevance 0.39
IL-2 levels in the brain areas analyzed were not influenced by the animals being subjected to the FST (data not shown), so the combined data for these two groups were used.
Neg (not) Regulation (influenced) of IL-2 in brain associated with eae
13) Confidence 0.27 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 0.59 Pain Relevance 0.32
As shown in Table 5, none of the dosages of dioscorea used affected IL-2 levels in the prefrontal cortex and cerebral cortex in sham-operated rats.
Regulation (affected) of IL-2 in cerebral cortex associated with cerebral cortex
14) Confidence 0.27 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 0.61 Pain Relevance 0.33
The effects of dioscorea on IL-2 levels in brain tissue were also examined using an enzyme linked immunosorbent assay (ELISA).


Spec (examined) Regulation (effects) of IL-2 in brain
15) Confidence 0.27 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 1.17 Pain Relevance 0.21
The concentrations of IL-1alpha, IL-1beta, IL-2, TNF-alpha and TGF-beta were increased in bronchoalveolar lavage specimens following gastric fluid aspiration compared to normal saline.


Regulation (concentrations) of IL-2
16) Confidence 0.16 Published 2007 Journal Respir Res Section Abstract Doc Link PMC2213655 Disease Relevance 0.72 Pain Relevance 0.22
SNC 80 also had no effect on concanavalin A-, anti-T cell receptor-, interleukin-2- and anti-T cell receptor + interleukin-2-induced splenic and thymic lymphocyte proliferation in most experiments.
Neg (no) Regulation (effect) of interleukin-2 in lymphocyte
17) Confidence 0.15 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9694952 Disease Relevance 0 Pain Relevance 0.22
The effect of adenovirus-mediated interleukin-2 (IL-2) gene on rat basal nociceptive response and chronic neuropathic pain was explored.
Regulation (effect) of interleukin-2 associated with nociception and neuropathic pain
18) Confidence 0.12 Published 2003 Journal Gene Ther. Section Abstract Doc Link 12883536 Disease Relevance 0.53 Pain Relevance 0.43
As shown in Table 5, none of the dosages of dioscorea used affected IL-2 levels in the prefrontal cortex and cerebral cortex in sham-operated rats.
Regulation (affected) of IL-2 in cortex associated with cerebral cortex
19) Confidence 0.09 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 0.61 Pain Relevance 0.33
Phenytoin attenuated by approximately 50% the release of IL-1 alpha, IL-1 beta, and TNF-alpha from LPS-stimulated microglia, but had minimal effects on the release of IL-2, IL-4, IL-6, IL-10, MCP-1, and TGF-alpha.
Regulation (effects) of IL-2 in microglia
20) Confidence 0.01 Published 2009 Journal Glia Section Abstract Doc Link 19115387 Disease Relevance 0 Pain Relevance 1.67

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