INT62468

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Context Info
Confidence 0.18
First Reported 1996
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.14
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (PTGS1) small molecule metabolic process (PTGS1) aging (PTGS1)
Golgi apparatus (PTGS1) endoplasmic reticulum (PTGS1) lipid metabolic process (PTGS1)
Anatomy Link Frequency
cleavage 2
PTGS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 81.92 Quite High
aspirin 3 43.56 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ApoPGHS-1, pretreated with N-(carboxyheptyl)maleimide, was resistant to trypsin cleavage, suggesting that the carboxylate functionality of the maleimide binds in the cyclooxygenase channel.
Protein_catabolism (cleavage) of ApoPGHS-1 in cleavage
1) Confidence 0.18 Published 1996 Journal J. Med. Chem. Section Abstract Doc Link 8648609 Disease Relevance 0 Pain Relevance 0
All of the selective PGHS-2 inhibitors protected against tryptic cleavage of apoPGHS-1 but did not inhibit the protein's cyclooxygenase activity.
Protein_catabolism (cleavage) of apoPGHS-1 in cleavage
2) Confidence 0.12 Published 1996 Journal Biochemistry Section Abstract Doc Link 8703911 Disease Relevance 0.14 Pain Relevance 0.15

General Comments

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