INT62474

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Context Info
Confidence 0.48
First Reported 1996
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
pore 1
brain 1
Slc6a7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 16 99.32 Very High Very High Very High
Potency 1 93.76 High High
opioid receptor 1 85.44 High High
antagonist 1 80.72 Quite High
opiate 1 79.92 Quite High
Neurotransmitter 2 53.72 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that (1) PROT uptake is electrogenic, (2) individual transporter currents are voltage-independent, and (3) GGFL is a nonsubstrate inhibitor that interacts either with an extracellular domain of PROT or in an externally accessible pore.
PROT Binding (interacts) of in pore associated with enkephalin
1) Confidence 0.48 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10414958 Disease Relevance 0 Pain Relevance 0.60
These findings indicate that enkephalins competitively inhibit mammalian brain PROT through a direct interaction with the transporter protein at or near the L-proline binding site.
PROT Binding (interaction) of in brain associated with enkephalin
2) Confidence 0.34 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8649341 Disease Relevance 0 Pain Relevance 0.85

General Comments

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