INT62481

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Context Info
Confidence 0.60
First Reported 1996
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Link Frequency
brain 1
Penk (Rattus norvegicus)
Slc6a7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 16 100.00 Very High Very High Very High
Potency 1 91.44 High High
opioid receptor 1 87.44 High High
antagonist 1 82.72 Quite High
opiate 1 81.92 Quite High
Neurotransmitter 2 63.84 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings indicate that enkephalins competitively inhibit mammalian brain PROT through a direct interaction with the transporter protein at or near the L-proline binding site.
enkephalin Negative_regulation (inhibit) of PROT in brain associated with enkephalin
1) Confidence 0.60 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8649341 Disease Relevance 0 Pain Relevance 0.86
Des-Tyr-Leu-enkephalin (GGFL), a competitive peptide inhibitor of PROT, reduced the rat PROT-associated current to control levels.
Des-Tyr-Leu-enkephalin Negative_regulation (inhibitor) of PROT associated with enkephalin
2) Confidence 0.03 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10414958 Disease Relevance 0 Pain Relevance 0.65

General Comments

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