INT62487

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Context Info
Confidence 0.73
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 35
Total Number 35
Disease Relevance 36.24
Pain Relevance 2.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HIVEP1) intracellular (HIVEP1) DNA binding (HIVEP1)
cytoplasm (HIVEP1)
Anatomy Link Frequency
T cells 4
macrophages 1
Visceral 1
canal 1
brain 1
HIVEP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 63 99.32 Very High Very High Very High
opiate 10 99.02 Very High Very High Very High
Glutamate 50 98.40 Very High Very High Very High
cocaine 49 98.40 Very High Very High Very High
Neurobehavioral 7 96.40 Very High Very High Very High
Inflammation 50 95.76 Very High Very High Very High
chemokine 52 94.08 High High
Central nervous system 69 92.16 High High
depression 13 91.32 High High
antagonist 29 86.48 High High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 2191 100.00 Very High Very High Very High
Hepatitis C Virus Infection 367 100.00 Very High Very High Very High
Disease 82 100.00 Very High Very High Very High
Leishmaniasis 16 100.00 Very High Very High Very High
Apoptosis 192 99.92 Very High Very High Very High
Infection 593 99.88 Very High Very High Very High
Reprotox - General 2 33 99.72 Very High Very High Very High
Sprains And Strains 56 99.60 Very High Very High Very High
Death 90 99.12 Very High Very High Very High
Parkinson's Disease 9 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To study the intracellular location of GAAPs, an Ab was raised against a GAAP peptide, SSIEDDFNYGSSV (h-GAAP aa 11–23 and v-GAAP aa 10–22).
Localization (location) of GAAP
1) Confidence 0.73 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.30 Pain Relevance 0
Deletion of v-GAAP from VACV did not affect virus replication in cell culture, but affected virulence in a murine model of infection. v-GAAP therefore represents a new virus-encoded apoptosis inhibitor. v-GAAP is remarkable in that it is very closely related to a previously uncharacterised human protein (h-GAAP) that is conserved in a wide range of eukaryotes, is expressed in all 16 human tissues tested, and is essential for cell viability.
Localization (Deletion) of v-GAAP associated with apoptosis and infection
2) Confidence 0.63 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 1.07 Pain Relevance 0.03
Neuronal dysfunction and cell death in patients with human immunodeficiency virus type-1 (HIV-1) infection may be mediated by HIV-1 proteins and products released from infected cells.
Localization (released) of HIV-1 in Neuronal associated with acquired immune deficiency syndrome or hiv infection, infection and death
3) Confidence 0.60 Published 1998 Journal Neuroscience Section Abstract Doc Link 9483506 Disease Relevance 0.76 Pain Relevance 0.07
Localization of HIV-1 in human brain using polymerase chain reaction/in situ hybridization and immunocytochemistry.
Localization (Localization) of HIV in brain associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.47 Published 1996 Journal Ann. Neurol. Section Title Doc Link 8651642 Disease Relevance 1.46 Pain Relevance 0.08
Quantification of HIV-1 RNA
Localization (Quantification) of HIV-1 associated with acquired immune deficiency syndrome or hiv infection
5) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2741601 Disease Relevance 0.15 Pain Relevance 0.08
Compartmentalization of HIV-1 within the Female Genital Tract Is Due to Monotypic and Low-Diversity Variants Not Distinct Viral Populations

Background

Localization (Compartmentalization) of HIV-1 associated with acquired immune deficiency syndrome or hiv infection
6) Confidence 0.40 Published 2009 Journal PLoS ONE Section Title Doc Link PMC2741601 Disease Relevance 0.63 Pain Relevance 0
Raltegravir was also >1000-fold more selective for HIV-1 integrase as compared with other phosphoryltransferases tested, including the polymerase and RNase H activities of HIV-1 reverse transcriptase and the human polymerases ?
Localization (selective) of HIV associated with acquired immune deficiency syndrome or hiv infection
7) Confidence 0.27 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504063 Disease Relevance 0.60 Pain Relevance 0
Moreover, [39] found the lectins from R. communis to inhibit HIV-1 reverse transcriptase.
Localization (reverse transcriptase) of HIV-1 associated with acquired immune deficiency syndrome or hiv infection
8) Confidence 0.18 Published 2008 Journal J Ethnobiol Ethnomed Section Body Doc Link PMC2390512 Disease Relevance 1.11 Pain Relevance 0.22
Evidence detailing the epidemiology of HIV-SGD suggests the involvement of a viral opportunist in its pathogenesis, yet the specific etiology of HIV-SGD remains unclear.
Localization (etiology) of HIV-SGD associated with acquired immune deficiency syndrome or hiv infection
9) Confidence 0.12 Published 2010 Journal Infect Agent Cancer Section Body Doc Link PMC3002692 Disease Relevance 1.11 Pain Relevance 0
-secreting, HIV-1-specific T cells persisting at one year post vaccination.
Localization (secreting) of HIV-1 in T cells associated with acquired immune deficiency syndrome or hiv infection
10) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965084 Disease Relevance 0.43 Pain Relevance 0
To evaluate inhibition of HIV-1 replication by these three genetic inhibitors, we transduced a CD4+ cell line (CEMx174) with the HIV-shI-GFP, VRX494, or M589 vectors.
Localization (replication) of HIV-1 associated with acquired immune deficiency syndrome or hiv infection
11) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925957 Disease Relevance 0.89 Pain Relevance 0
Binding antibodies were likely functional in part, given the correlation with the ability to neutralize HIV SF162, a strain that is relatively easy to neutralize.
Localization (neutralize) of HIV associated with acquired immune deficiency syndrome or hiv infection and sprains and strains
12) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810329 Disease Relevance 0.72 Pain Relevance 0
After three vaccinations of ADMVA, two volunteers were able to neutralize the subtype C viruses, and three volunteers (one placebo and two high dose volunteers) were able to neutralize HIV-1 laboratory strain NL43. 21/36 ADMVA recipients (58%) were able to neutralize the laboratory HIV strain SF162 at Week 28, which trended towards agreement with the formation of anti-gp120 binding antibodies (Kappa?
Localization (neutralize) of HIV associated with acquired immune deficiency syndrome or hiv infection and sprains and strains
13) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810329 Disease Relevance 1.21 Pain Relevance 0
Resident brain macrophages or microglia infected with HIV-1 or exposed to HIV-encoded proteins secrete proinflammatory cytokines e.g. interleukin-1?
Localization (secrete) of HIV in macrophages associated with acquired immune deficiency syndrome or hiv infection and cytokine
14) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.99 Pain Relevance 0.21
We hereby report an unusual case presentation of Visceral leishmaniasis/HIV co-infection with additional features of Parkinsonism and hyperuriciemia in an Indian male patient aged about 50 years.


Localization (presentation) of HIV in Visceral associated with parkinson's disease, leishmaniasis, acquired immune deficiency syndrome or hiv infection and infection
15) Confidence 0.07 Published 2008 Journal Cases J Section Abstract Doc Link PMC2561008 Disease Relevance 1.32 Pain Relevance 0
(Fig. 3) results in enhanced HIV replication, a process that correlates with activation of NF-?
Localization (replication) of HIV associated with acquired immune deficiency syndrome or hiv infection
16) Confidence 0.06 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.33 Pain Relevance 0
In simplified terms, activation of lymphocytes outside of the nervous system favors their promiscuous entry [43,27], and when infected by HIV, these activated CD4 cells can release HIV into the surrounding fluid.
Localization (release) of HIV in lymphocytes associated with acquired immune deficiency syndrome or hiv infection
17) Confidence 0.06 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1299327 Disease Relevance 1.17 Pain Relevance 0.12
Opiates exacerbate human immunodeficiency virus type 1 (HIV-1) Tat(1-72)-induced release of key proinflammatory cytokines by astrocytes, which may accelerate HIV neuropathogenesis in opiate abusers.
Localization (release) of HIV-1 in astrocytes associated with acquired immune deficiency syndrome or hiv infection, opiate and cytokine
18) Confidence 0.05 Published 2006 Journal Glia Section Abstract Doc Link 16206161 Disease Relevance 0.65 Pain Relevance 0.50
Preparation of HIV and SHIV challenge virus
Localization (Preparation) of HIV associated with acquired immune deficiency syndrome or hiv infection
19) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765621 Disease Relevance 0.55 Pain Relevance 0
Following the diagnosis of HIV infection among males, sexual dysfunction results from psychological factors, physical factors, and changes in sexual habits (e.g., adherence to safe sex practices).5 Low sexual desire and erectile dysfunction may be associated with older age and depression in men with HIV.6 Erectile dysfunction may occur as the result of the psychosocial impact of HIV diagnosis5 following the decrease in testosterone levels that accompanies some medications,7 testicular atrophy, or vacuolar myelopathy.8 Highly active antiretroviral therapy (HAART) has previously been shown to provide the best clinical management for HIV-infected patients, as it decreases the prevalence of hypogonadism and advanced HIV disease, which are principal causes of sexual dysfunction in people infected with HIV.7
Localization (disease) of HIV associated with spinal cord diseases, reprotox - general 2, reprotox - general 3, depression, hypoactive sexual desire disorder, acquired immune deficiency syndrome or hiv infection, disease and infection
20) Confidence 0.05 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2882546 Disease Relevance 3.03 Pain Relevance 0.26

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