INT62497

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Context Info
Confidence 0.26
First Reported 1995
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.19
Pain Relevance 3.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
granulocyte 1
dorsal horn 1
T-helper cells 1
Il4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 7 100.00 Very High Very High Very High
Eae 102 99.44 Very High Very High Very High
cytokine 68 98.42 Very High Very High Very High
Spinal cord 46 98.32 Very High Very High Very High
Dorsal horn 36 97.92 Very High Very High Very High
withdrawal 24 97.36 Very High Very High Very High
allodynia 24 96.92 Very High Very High Very High
Brush evoked pain 9 95.80 Very High Very High Very High
Dynorphin 3 94.48 High High
Analgesic 13 92.96 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 45 99.60 Very High Very High Very High
Neuropathic Pain 120 96.92 Very High Very High Very High
Hyperalgesia 42 90.76 High High
INFLAMMATION 107 90.04 High High
Ulcers 4 87.60 High High
Edema 4 84.44 Quite High
Hypersensitivity 6 84.36 Quite High
Hemorrhage 2 84.16 Quite High
Pain 37 83.68 Quite High
Nociception 24 81.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Animals inoculated with S4IL4 1 week after SNL showed a statistically significant reduction in mechanical allodynia that was continuous and sustained.
S4IL4 Binding (inoculated) of associated with allodynia and eae
1) Confidence 0.26 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395302 Disease Relevance 0.66 Pain Relevance 0.56
Animals inoculated with S4IL4 1 week after SNL showed a substantial reduction in the levels of IL-1?
S4IL4 Binding (inoculated) of associated with eae
2) Confidence 0.26 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395302 Disease Relevance 0.44 Pain Relevance 0.85
IL-4 produced by subcutaneous inoculation of S4IL4 suppressed expression of p-p38 but not pERK in the dorsal horn.
S4IL4 Binding (inoculation) of in dorsal horn associated with dorsal horn
3) Confidence 0.26 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395302 Disease Relevance 1.12 Pain Relevance 1.10
The supernatant obtained from the BALF was assayed for interleukin-4 (IL-4) and interleukin-13 (IL-13) concentration within one month of processing, using the enzyme-linked immunosorbent assay (ELISA)-based Quantikine M kits specific for rat IL-4 and IL-13 (R&D Systems, Minneapolis, USA), according to the manufacturer's instructions.
IL-4 Binding (specific) of
4) Confidence 0.20 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1876456 Disease Relevance 0.78 Pain Relevance 0.39
SDS-PAGE and immunoblotting analysis of supernatants of bone marrow T-helper cells incubated overnight with melatonin revealed the presence of two proteins with an apparent molecular weight of 15 and 67 kDa, which were recognized by both anti-common opioid sequence (Tyr-Gly-Gly-Phe) and anti-IL4 mAbs.
IL4 Binding (recognized) of in T-helper cells associated with opioid
5) Confidence 0.15 Published 1996 Journal J. Pineal Res. Section Abstract Doc Link 8981257 Disease Relevance 0.14 Pain Relevance 0.74
That effect was attenuated by probiotic therapy. 2) Probiotic therapy seems to be effective in treatment of fungal colonization of GI tract. 3) Lactobacillus acidophilus therapy shortens the duration of fungal colonization of mucosa (enhanced Candida clearance is associated with IL-4, INF-gamma response).
IL-4 Binding (associated) of
6) Confidence 0.04 Published 2006 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 17242486 Disease Relevance 0.64 Pain Relevance 0.07
A number of cytokines are used as haemopoietic growth factors and this review focuses on toxicities associated with granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF), interleukin (IL)-1, IL-3, IL-4, IL-6 and macrophage colony-stimulating factor (M-CSF).
IL-4 Binding (associated) of in granulocyte associated with cytokine
7) Confidence 0.01 Published 1995 Journal Drug Saf Section Abstract Doc Link 8652081 Disease Relevance 0.40 Pain Relevance 0.17

General Comments

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