INT62500

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Context Info
Confidence 0.56
First Reported 1996
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 4.54
Pain Relevance 4.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ptgs1) aging (Ptgs1) Golgi apparatus (Ptgs1)
endoplasmic reticulum (Ptgs1) cytoplasm (Ptgs1) lipid binding (Ptgs1)
Anatomy Link Frequency
lung 2
spinal 1
neurons 1
renal medulla 1
afferent neurons 1
Ptgs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 48 99.84 Very High Very High Very High
qutenza 9 99.84 Very High Very High Very High
COX2 7 99.42 Very High Very High Very High
cOX1 4 99.42 Very High Very High Very High
medulla 5 99.28 Very High Very High Very High
cINOD 13 99.24 Very High Very High Very High
Perioperative pain 6 99.16 Very High Very High Very High
anesthesia 3 98.90 Very High Very High Very High
substance P 8 98.60 Very High Very High Very High
ketamine 2 98.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 54 99.84 Very High Very High Very High
Injury 8 99.60 Very High Very High Very High
Post Operative Pain 6 99.16 Very High Very High Very High
Hypertension 3 98.78 Very High Very High Very High
Ganglion Cysts 7 92.52 High High
Cirrhosis 8 92.16 High High
Pain 60 87.20 High High
Glioma 2 83.80 Quite High
Pressure And Volume Under Development 2 83.60 Quite High
Apoptosis 6 76.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to investigate a possible interaction between ketoprofen and caffeine on prostaglandin (PG) biosynthesis and cyclooxygenase (COX) mRNA expression in the rat renal medulla ex vivo.
Transcription (expression) of cyclooxygenase in renal medulla associated with medulla
1) Confidence 0.56 Published 2001 Journal Pharmacology Section Abstract Doc Link 11729362 Disease Relevance 0.09 Pain Relevance 0.41
In contrast, the expression of mRNA for cyclooxygenase-1 was constitutive and was never affected by NSAIDs.
Transcription (expression) of cyclooxygenase-1 associated with cinod
2) Confidence 0.36 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9851595 Disease Relevance 0.44 Pain Relevance 0.59
OBJECTIVE AND DESIGN: The purpose of the present study was to evaluate the effect of urethane, pentobarbital sodium and ketamine-xylazine anesthesia upon constitutive and inducible cyclooxygenase (COX-1; COX-2) and nitric oxide synthase (eNOS; iNOS) mRNA levels in the lung.
Transcription (levels) of cyclooxygenase in lung associated with anesthesia and ketamine
3) Confidence 0.26 Published 2000 Journal Inflamm. Res. Section Abstract Doc Link 11211925 Disease Relevance 0 Pain Relevance 0.15
The cyclooxygenase activity of the membrane protein prostaglandin H2 synthase isoform 1 (PGHS-1) is the target of the nonsteroidal antiinflammatory drugs (NSAIDs).
Transcription (activity) of prostaglandin H2 synthase isoform 1 associated with inflammation and cinod
4) Confidence 0.25 Published 1996 Journal Biochemistry Section Abstract Doc Link 8652509 Disease Relevance 0.17 Pain Relevance 0.25
Different patterns of spinal cyclooxygenase-1 and cyclooxygenase-2 mRNA expression in inflammatory and postoperative pain.
Transcription (expression) of cyclooxygenase-1 in spinal associated with inflammation, perioperative pain and cox1
5) Confidence 0.18 Published 2006 Journal Basic Clin. Pharmacol. Toxicol. Section Title Doc Link 16918720 Disease Relevance 0.74 Pain Relevance 0.90
The aim of this study was to examine the impact of ablation of capsaicin-sensitive neurons and the tachykinin NK(1) receptor antagonist A5330 on the susceptibility of the portal hypertensive gastric mucosa to ethanol-induced injury and its effects on gastric cyclooxygenase (COX) and nitric oxide synthase (NOS) mRNA expression.
Transcription (expression) of gastric cyclooxygenase in neurons associated with qutenza, antagonist, injury and hypertension
6) Confidence 0.12 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18555214 Disease Relevance 0.89 Pain Relevance 0.53
The AA is subsequently transformed by cyclooxygenase (COX) and lipoxygenase pathways to prostaglandins, thromboxane, and leukotrienes, collectively termed eicosanoids.
Transcription (transformed) of cyclooxygenase
7) Confidence 0.10 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2315656 Disease Relevance 1.67 Pain Relevance 0.93
By immunoblotting and reverse-transcription polymerase chain reaction, we showed that gamma-mangostin concentration-dependently inhibited lipopolysaccharide (LPS)-induced expression of COX-2 protein and its mRNA, but not those of constitutive COX-1 cyclooxygenase.
Transcription (expression) of COX-1 cyclooxygenase
8) Confidence 0.09 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15322259 Disease Relevance 0.16 Pain Relevance 0
Nitric oxide synergistically potentiates interleukin-1 beta-induced increase of cyclooxygenase-2 mRNA levels, resulting in the facilitation of substance P release from primary afferent neurons: involvement of cGMP-independent mechanisms.
Transcription (levels) of cyclooxygenase in afferent neurons associated with cox2 and substance p
9) Confidence 0.08 Published 2002 Journal Neuropharmacology Section Title Doc Link 12384172 Disease Relevance 0.38 Pain Relevance 0.52
Urethane suppresses rat lung inducible cyclooxygenase and nitric oxide synthase mRNA levels.
Transcription (levels) of cyclooxygenase in lung associated with cox1
10) Confidence 0.08 Published 2000 Journal Inflamm. Res. Section Title Doc Link 11211925 Disease Relevance 0 Pain Relevance 0.24

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