INT62507

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Context Info
Confidence 0.16
First Reported 1996
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 2.45
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Scr (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 8 90.80 High High
ischemia 13 87.80 High High
bradykinin 10 84.88 Quite High
peptic ulcer disease 1 65.68 Quite High
antagonist 8 62.52 Quite High
agonist 5 58.00 Quite High
Inflammation 28 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Migraine 4 5.00 Very Low Very Low Very Low
endometriosis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Renal Failure 196 91.04 High High
Cv Unclassified Under Development 12 87.80 High High
Renal Failure 4 87.20 High High
Crystal Associated Disease 32 84.48 Quite High
Disorders Of Creatine Metabolism 5 78.00 Quite High
Kidney Stones 76 76.24 Quite High
Disease 41 75.20 Quite High
Immunization 1 67.68 Quite High
Ulcers 1 65.36 Quite High
Reperfusion Injury 32 63.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the variant does not affect SCr in young individuals but rather how SCr increases with age.
Neg (not) Regulation (affect) of SCr
1) Confidence 0.16 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912386 Disease Relevance 0.25 Pain Relevance 0
No changes in SCr or CsA level were noted in the patients who received ranitidine.
Neg (No) Regulation (changes) of SCr
2) Confidence 0.11 Published 1996 Journal Clin Transplant Section Abstract Doc Link 8652895 Disease Relevance 0.58 Pain Relevance 0.10
B1KO had a significant reduction in sCr at all times analyzed, meanwhile B2KO mice presented lower sCr values only at 4 and 24 h.
Regulation (values) of sCr
3) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 0.35 Pain Relevance 0.26
These subjects had 5.2 SCr measurements on average (geometric mean) and we used the median SCr value for each individual in the subsequent analysis.
Regulation (value) of SCr
4) Confidence 0.10 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912386 Disease Relevance 0.55 Pain Relevance 0.05
We also show that this variant interacts with age-related increase in SCr levels with little or no effect on SCr before the age of 50 years, followed by a rapidly growing effect with increasing age.
Neg (little) Regulation (effect) of SCr
5) Confidence 0.10 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912386 Disease Relevance 0.73 Pain Relevance 0
For example, when testing for an interaction effect on SCr between age and the rs4293393-T allele count, the null model included as covariates age, sex and the rs4293393-T allele count.
Regulation (effect) of SCr
6) Confidence 0.10 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912386 Disease Relevance 0 Pain Relevance 0

General Comments

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