INT62510

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Context Info
Confidence 0.60
First Reported 1996
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 32
Total Number 32
Disease Relevance 11.79
Pain Relevance 5.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
MCs 8
muscle 2
MCS 2
heart 2
visceral 1
MCS (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 10 100.00 Very High Very High Very High
Anterior cingulate 4 99.98 Very High Very High Very High
visual analogue scale 53 99.56 Very High Very High Very High
spastic colon 20 99.56 Very High Very High Very High
Analgesic 4 99.08 Very High Very High Very High
Pain refractory 1 99.04 Very High Very High Very High
antidepressant 74 98.98 Very High Very High Very High
Pain 112 98.80 Very High Very High Very High
deep brain stimulation 2 98.52 Very High Very High Very High
medulla 3 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Interstitial Cystitis 10 100.00 Very High Very High Very High
Overactive Bladder 4 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

7 99.56 Very High Very High Very High
Neuropathic Pain 7 99.52 Very High Very High Very High
Functional Bowel Disorder 18 99.46 Very High Very High Very High
Anaphylaxis 24 99.12 Very High Very High Very High
Intractable Pain 1 99.04 Very High Very High Very High
Apoptosis 116 98.80 Very High Very High Very High
Depression 145 96.20 Very High Very High Very High
Pain 85 96.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As reported by other researchers [44,46-48], we observed increasing mean MCS scores and decreasing mean PCS scores with increasing age.
Positive_regulation (increasing) of MCS
1) Confidence 0.60 Published 2007 Journal BMC Public Health Section Body Doc Link PMC2212642 Disease Relevance 0.11 Pain Relevance 0.11
The mean MCS and PCS scores for VA enrollees who filled out a questionnaire in 1999 or 2000 were 42.8 and 40.7 for women aged 18 to 44 years and 43.4 and 40.2 for men aged 18 to 44.
Positive_regulation (mean) of MCS
2) Confidence 0.43 Published 2007 Journal BMC Public Health Section Body Doc Link PMC2212642 Disease Relevance 0.23 Pain Relevance 0
Although the difference was small, participants who had deployed to Southwest Asia, Kosovo, and Bosnia between 1998 and 2001 had slightly more favorable weighted MCS and PCS scores; this difference persisted in the adjusted MCS but not PCS scores.
Positive_regulation (weighted) of MCS
3) Confidence 0.43 Published 2007 Journal BMC Public Health Section Body Doc Link PMC2212642 Disease Relevance 0.13 Pain Relevance 0
The number of activated MCs was decreased in the intervention group after treatment, showing significant difference as compared with that before treatment as well as with that in the control group after treatment (P<0.01).
Positive_regulation (activated) of MCs in MCs
4) Confidence 0.42 Published 2009 Journal Chin J Integr Med Section Body Doc Link 19568715 Disease Relevance 0.12 Pain Relevance 0
METHODS: Thirty-four patients with intractable neuropathic pain underwent MCS; 19 patients had cerebral lesions, and 15 had non-cerebral lesions.
Positive_regulation (underwent) of MCS
5) Confidence 0.40 Published 2008 Journal Clin Neurophysiol Section Body Doc Link 18329955 Disease Relevance 0 Pain Relevance 0
Mean rCBF in the anterior cingulate increased during MCS in patients with good analgesic efficacy, while it decreased in those with poor clinical outcome; conversely, thalamic rCBF increased in the two groups, albeit to a greater extent in patients with good clinical results.
Positive_regulation (increased) of MCS in anterior associated with analgesic and anterior cingulate
6) Confidence 0.40 Published 1997 Journal Stereotact Funct Neurosurg Section Abstract Doc Link 9711707 Disease Relevance 0.35 Pain Relevance 0.73
Intragranular activation of bladder MCs is a characteristic pathological finding in patients with IC.
Positive_regulation (activation) of MCs in MCs
7) Confidence 0.39 Published 1996 Journal Br J Urol Section Body Doc Link 8653316 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: To investigate the presence of progesterone receptors and the extent and type of degranulation exhibited by the increased numbers of mast cells (MCs) found in interstitial cystitis (IC), a painful bladder disorder which occurs almost exclusively in women, worsens perimenstrually and is characterized by increased numbers of oestradiol receptor (OR)-positive MCs.
Positive_regulation (increased) of MCs in mast cells associated with pain and interstitial cystitis
8) Confidence 0.39 Published 1996 Journal Br J Urol Section Abstract Doc Link 8653316 Disease Relevance 0.17 Pain Relevance 0.27
MCs were activated to various degrees and were often near to neuronal processes.
Positive_regulation (activated) of MCs in MCs
9) Confidence 0.39 Published 1996 Journal Br J Urol Section Body Doc Link 8653316 Disease Relevance 0 Pain Relevance 0
RESULTS: Over 85% of bladder MCs expressed high affinity PRs, but the number of PR-positive MCs in patients with IC did not differ significantly from that of controls despite the overall increase in MCs seen in IC.
Positive_regulation (increase) of MCs in MCs
10) Confidence 0.39 Published 1996 Journal Br J Urol Section Body Doc Link 8653316 Disease Relevance 0 Pain Relevance 0
Eleven consecutive patients undergoing MCS because of neuropathic refractory pain, ranging in age from 25 to 71 years, were included in the study.
Positive_regulation (undergoing) of MCS in MCS associated with pain refractory and neuropathic pain
11) Confidence 0.39 Published 2002 Journal Neurophysiol Clin Section Abstract Doc Link 12490329 Disease Relevance 0.67 Pain Relevance 0.43
BACKGROUND: A subset of patients with irritable bowel syndrome (IBS) have an increased number of mast cells (MCs) in the colonic mucosa.
Positive_regulation (increased) of MCs in mast cells associated with spastic colon
12) Confidence 0.36 Published 2008 Journal Gut Section Abstract Doc Link 18194987 Disease Relevance 0.32 Pain Relevance 0.41
Previously, we have demonstrated a significant augmentation of infiltrated MCs in heart sections of anaphylactic deaths, a high level of serum mast cell tryptase and a severe degree of pulmonary congestion and edema (Perskvist et al 2006).
Positive_regulation (augmentation) of MCs in heart associated with anaphylaxis and edema
13) Confidence 0.30 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350147 Disease Relevance 0.74 Pain Relevance 0
The stimulation of these sites through MCS (motor cortex stimulation) and DBS (deep brain stimulation) has proven effective for treating a number of neuropathic and nociceptive pain states that are not responsive or amenable to other therapies or types of neurostimulation.
Positive_regulation (stimulation) of MCS in cortex associated with deep brain stimulation, neuropathic pain and painful pain
14) Confidence 0.28 Published 2010 Journal Pain Physician Section Abstract Doc Link 20309382 Disease Relevance 0.42 Pain Relevance 0.36
Activated MCs release a wide variety of bioactive mediators.
Positive_regulation (Activated) of MCs in MCs
15) Confidence 0.28 Published 2009 Journal Dig Dis Section Abstract Doc Link 20203509 Disease Relevance 0.18 Pain Relevance 0.04
Its mechanism of action might be through the adjustment of MCs activation to decrease visceral hypersensitivity.


Positive_regulation (activation) of MCs in visceral
16) Confidence 0.28 Published 2009 Journal Chin J Integr Med Section Body Doc Link 19568715 Disease Relevance 0 Pain Relevance 0
The activation of mast cells (MCs) of six patients chosen from each group was detected as well before and after treatment.
Positive_regulation (activation) of MCs in MCs
17) Confidence 0.28 Published 2009 Journal Chin J Integr Med Section Body Doc Link 19568715 Disease Relevance 0.15 Pain Relevance 0
The intestinal mucosa of irritable bowel syndrome patients contains on average an increased number of MCs.
Positive_regulation (increased) of MCs in bowel associated with spastic colon
18) Confidence 0.28 Published 2006 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 16371078 Disease Relevance 0.55 Pain Relevance 0.41
PURPOSE: Interstitial cystitis is characterized by an increased number of activated MCs in the detrusor muscle.
Positive_regulation (increased) of MCs in muscle associated with overactive bladder and interstitial cystitis
19) Confidence 0.25 Published 2006 Journal J. Urol. Section Abstract Doc Link 16407046 Disease Relevance 0.42 Pain Relevance 0.10
PURPOSE: Interstitial cystitis is characterized by an increased number of activated MCs in the detrusor muscle.
Positive_regulation (activated) of MCs in muscle associated with overactive bladder and interstitial cystitis
20) Confidence 0.25 Published 2006 Journal J. Urol. Section Abstract Doc Link 16407046 Disease Relevance 0.42 Pain Relevance 0.10

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