INT62511

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Context Info
Confidence 0.50
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 6.77
Pain Relevance 2.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
MCs 2
muscle 1
bladder 1
bowel 1
primary motor cortex 1
MCS (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 93 99.56 Very High Very High Very High
Pain 65 99.22 Very High Very High Very High
interstitial cystitis 5 99.14 Very High Very High Very High
spastic colon 5 99.14 Very High Very High Very High
Morphine 3 96.96 Very High Very High Very High
Deafferentation 2 93.28 High High
Neuropeptide 1 86.88 High High
Inflammation 2 82.04 Quite High
fibrosis 2 79.80 Quite High
nud 2 74.80 Quite High
Disease Link Frequency Relevance Heat
Overactive Bladder 2 100.00 Very High Very High Very High
Fibromyalgia 92 99.56 Very High Very High Very High
Disease 66 99.48 Very High Very High Very High
Pain 62 99.22 Very High Very High Very High
Functional Bowel Disorder 5 99.14 Very High Very High Very High
Interstitial Cystitis 5 99.14 Very High Very High Very High
Diabetes Mellitus 214 97.04 Very High Very High Very High
Sclerosis 1 91.36 High High
Obesity 30 88.92 High High
Coronary Artery Disease 6 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Disease severity correlated with loss of MCs and reduction in cold perception and pain perception.
Negative_regulation (loss) of MCs in MCs associated with pain and disease
1) Confidence 0.50 Published 2008 Journal Brain Section Abstract Doc Link 18515869 Disease Relevance 0.67 Pain Relevance 0.31
Pain scored 44 and 46 initially (on a scale in which 100 referred to maximum and 0 to no pain) and decreased within the first week to 20 and 28 in the MCS and bandage groups, respectively (P < .001 vs .010).
Negative_regulation (decreased) of MCS
2) Confidence 0.37 Published 2010 Journal J. Vasc. Surg. Section Body Doc Link 19879713 Disease Relevance 0 Pain Relevance 0
Parkinson's disease patients showed a significant increase in tactile and thermal thresholds (P < 0.01), a significant reduction in mechanical pain perception (P < 0.01) and significant loss of epidermal nerve fibres (ENFs) and Meissner corpuscles (MCs) (P < 0.01).
Negative_regulation (loss) of MCs in nerve associated with pain and disease
3) Confidence 0.37 Published 2008 Journal Brain Section Abstract Doc Link 18515869 Disease Relevance 0.78 Pain Relevance 0.29
Twelve patients received both MCS and repetitive transcranial magnetic stimulation (rTMS) of the primary motor cortex.
Negative_regulation (received) of MCS in primary motor cortex
4) Confidence 0.37 Published 2008 Journal Clin Neurophysiol Section Body Doc Link 18329955 Disease Relevance 0 Pain Relevance 0
Common findings between the current study and Voelker et al. include decreased mean PCS scores for those who were married or in the Army, and decreased mean MCS scores for service members who were in the Army, divorced, and had shorter lengths of service.
Negative_regulation (decreased) of MCS
5) Confidence 0.37 Published 2007 Journal BMC Public Health Section Body Doc Link PMC2212642 Disease Relevance 0.57 Pain Relevance 0.27
RESULTS: Over 85% of bladder MCs expressed high affinity PRs, but the number of PR-positive MCs in patients with IC did not differ significantly from that of controls despite the overall increase in MCs seen in IC.
Negative_regulation (number) of MCs in MCs
6) Confidence 0.36 Published 1996 Journal Br J Urol Section Body Doc Link 8653316 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: To investigate the presence of progesterone receptors and the extent and type of degranulation exhibited by the increased numbers of mast cells (MCs) found in interstitial cystitis (IC), a painful bladder disorder which occurs almost exclusively in women, worsens perimenstrually and is characterized by increased numbers of oestradiol receptor (OR)-positive MCs.
Negative_regulation (numbers) of MCs in bladder associated with pain and interstitial cystitis
7) Confidence 0.36 Published 1996 Journal Br J Urol Section Abstract Doc Link 8653316 Disease Relevance 0.17 Pain Relevance 0.27
The number of activated MCs was decreased in the intervention group after treatment, showing significant difference as compared with that before treatment as well as with that in the control group after treatment (P<0.01).
Negative_regulation (number) of MCs in MCs
8) Confidence 0.35 Published 2009 Journal Chin J Integr Med Section Body Doc Link 19568715 Disease Relevance 0.12 Pain Relevance 0
In males, the results confirmed that only social support predicted the PCS and MCS scores, while other variables did not predict either score.
Negative_regulation (predicted) of MCS
9) Confidence 0.35 Published 2008 Journal Biopsychosoc Med Section Body Doc Link PMC2569038 Disease Relevance 0 Pain Relevance 0
The intestinal mucosa of irritable bowel syndrome patients contains on average an increased number of MCs.
Negative_regulation (number) of MCs in bowel associated with spastic colon
10) Confidence 0.26 Published 2006 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 16371078 Disease Relevance 0.55 Pain Relevance 0.41
PURPOSE: Interstitial cystitis is characterized by an increased number of activated MCs in the detrusor muscle.
Negative_regulation (number) of MCs in muscle associated with overactive bladder and interstitial cystitis
11) Confidence 0.24 Published 2006 Journal J. Urol. Section Abstract Doc Link 16407046 Disease Relevance 0.42 Pain Relevance 0.10
There was a significant correlation between the number of infiltrated MCs in the lung sections of the HLT group and the femoral blood tryptase concentration (p < 0.05).


Negative_regulation (number) of MCs in lung
12) Confidence 0.19 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350147 Disease Relevance 0.40 Pain Relevance 0.26
In contrast, although figure 4 shows that the MCS also declines with age, the declining health status broadly parallels that found in the general population as a whole, being at most about one third to one half a standard deviation below the population norms.


Negative_regulation (declines) of MCS
13) Confidence 0.07 Published 2003 Journal BMC Pulm Med Section Body Doc Link PMC317322 Disease Relevance 0.08 Pain Relevance 0
Hussain et al. [11] reported PCS and MCS summary scores and results according to several patient characteristics.
Negative_regulation (reported) of MCS
14) Confidence 0.06 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1187913 Disease Relevance 0.33 Pain Relevance 0.09
The decrease in MCS was relatively smaller than in PCS and about equal for the high-risk and T2D groups (approximately ?
Negative_regulation (decrease) of MCS associated with diabetes mellitus
15) Confidence 0.03 Published 2008 Journal International Journal of Clinical Practice Section Body Doc Link PMC2423273 Disease Relevance 0.85 Pain Relevance 0
Covariates determined to be significant were entered into a multivariable regression model predicting SF12-PCS and SF12-MCS.
Negative_regulation (predicting) of SF12-MCS
16) Confidence 0.03 Published 2008 Journal BJU Int. Section Body Doc Link 17924985 Disease Relevance 0.14 Pain Relevance 0
For the CG, a significant decline in PCS and MCS was observed between baseline and at follow-up (PCS: p = 0.023; MCS: p = 0.001).
Negative_regulation (decline) of MCS
17) Confidence 0.02 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC2894785 Disease Relevance 0.15 Pain Relevance 0.08
Organisational (provider) variables, i.e. a greater (patient) list size impacted negatively on the MCS and Self efficacy, whereas a higher number of physicians per practice determined MCS positively.
Spec (determined) Negative_regulation (determined) of MCS
18) Confidence 0.02 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC2945966 Disease Relevance 0.41 Pain Relevance 0.14
For both PCS and MCS, as household incomes decreased, respondentsÂ’ HRQoL decreased, such that those with incomes < $22,500 reported the greatest impact on HRQoL (p < 0.001 vs. ?
Negative_regulation (decreased) of MCS
19) Confidence 0.02 Published 2008 Journal International Journal of Clinical Practice Section Body Doc Link PMC2423273 Disease Relevance 0.78 Pain Relevance 0
We were also interested in whether baseline psychosocial risk markers, and follow-up threatening life events (assessed for the 6-months prior to follow-up), that predict the onset of CWP were associated with poor SF12-MCS and SF12-PCS scores, and quantified each of these relationships using the same univariate multinomial method.
Negative_regulation (poor) of SF12-MCS associated with fibrositis
20) Confidence 0.01 Published 2009 Journal Pain Section Body Doc Link PMC2631192 Disease Relevance 0.28 Pain Relevance 0.14

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