INT62512

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Context Info
Confidence 0.64
First Reported 1996
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 6.03
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
uterus 1
medial 1
brain 1
MCs 1
PRS (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 15 99.34 Very High Very High Very High
Spinal cord 3 99.28 Very High Very High Very High
amygdala 37 99.20 Very High Very High Very High
endometriosis 9 99.06 Very High Very High Very High
Dynorphin 11 98.96 Very High Very High Very High
Dopamine 46 97.76 Very High Very High Very High
agonist 36 96.84 Very High Very High Very High
tolerance 2 90.00 High High
nud 2 85.96 High High
pain pelvic 2 83.40 Quite High
Disease Link Frequency Relevance Heat
Sarcoma 28 100.00 Very High Very High Very High
Stress 10 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

10 99.92 Very High Very High Very High
Endometriosis 13 99.06 Very High Very High Very High
Disease 48 97.04 Very High Very High Very High
Aids-related Complex 11 96.28 Very High Very High Very High
Metastasis 5 87.40 High High
Dyspepsia 2 85.96 High High
Reprotox - General 1 1 84.76 Quite High
Cancer 18 84.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The presence of progesterone receptors (PRs) in five patients with IC and three controls was investigated using commercially available antibodies against PRs.
Spec (investigated) Gene_expression (presence) of PRs
1) Confidence 0.64 Published 1996 Journal Br J Urol Section Body Doc Link 8653316 Disease Relevance 0 Pain Relevance 0
RESULTS: Over 85% of bladder MCs expressed high affinity PRs, but the number of PR-positive MCs in patients with IC did not differ significantly from that of controls despite the overall increase in MCs seen in IC.
Gene_expression (expressed) of PRs in MCs
2) Confidence 0.50 Published 1996 Journal Br J Urol Section Body Doc Link 8653316 Disease Relevance 0 Pain Relevance 0
In group B, PRS decreased significantly with IVL and did not change with saline.
Gene_expression (decreased) of PRS
3) Confidence 0.42 Published 2009 Journal Masui Section Body Doc Link 19928509 Disease Relevance 0.15 Pain Relevance 0
Although radiation therapy has an established role in the management of soft tissue sarcoma [8,9], it is seldom used in PRS.
Gene_expression (used) of PRS associated with sarcoma
4) Confidence 0.25 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1592488 Disease Relevance 1.33 Pain Relevance 0.04
Oral cyclophosphamide plus methotrexate in combination with trastuzumab produced 4 PRs providing an objective response rate of 18% (95% CI 5–40%).
Gene_expression (produced) of PRs associated with methotrexate
5) Confidence 0.09 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1579231 Disease Relevance 0.94 Pain Relevance 0.05
By contrast, none of magnocellular DYN cells of the paraventricular and supraoptic nuclei coexpressed immunoreactive PRs.
Gene_expression (coexpressed) of PRs associated with dynorphin
6) Confidence 0.08 Published 2002 Journal Endocrinology Section Abstract Doc Link 12399433 Disease Relevance 0.27 Pain Relevance 0.53
The molecular basis of progesterone resistance in endometriosis may be related to an overall reduction in the levels of progesterone receptors (PRs) and the lack of the PR isoform named progesterone receptor B (PR-B).
Gene_expression (levels) of PRs associated with endometriosis
7) Confidence 0.05 Published 2006 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 16406281 Disease Relevance 1.17 Pain Relevance 0.60
After CRD or PRS, Fos expression was increased in spinal cord section (S1), nucleus tractus solitarius (NTS), paraventricular nucleus (PVN) of the hypothalamus, and in the medial nucleus of the amygdala (MeA).
Gene_expression (expression) of PRS in medial associated with stress, amygdala and spinal cord
8) Confidence 0.04 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19309441 Disease Relevance 1.08 Pain Relevance 0.55
For example, PRs are expressed within the BST and CeA [15], [54] and are activated by DA or D1-like receptor agonists in vitro [14] and in adult female rat brain [55].
Gene_expression (expressed) of PRs in brain associated with dopamine, agonist and amygdala
9) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2359852 Disease Relevance 0 Pain Relevance 0.33
In mice, it has been shown before that PRs are expressed in epithelial, stromal and myometrial cells of the uterus and their location and temporal variation within the tissue are regulated by both estrogens and progesterone [9,25,26].
Gene_expression (expressed) of PRs in uterus
10) Confidence 0.01 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.13 Pain Relevance 0
The mechanism that mediates this P4 effect remains unclear, as in ovariectomized mice, the expression of PRs fall as a consequence of the lack of E2 [7].
Gene_expression (expression) of PRs
11) Confidence 0.01 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0.15 Pain Relevance 0

General Comments

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