INT62521

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Context Info
Confidence 0.82
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 44
Total Number 52
Disease Relevance 2.66
Pain Relevance 47.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
spinal cord 2
spinal 1
AC2 1
sciatic nerve 1
brains 1
Oprm1 (Mus musculus)
Oprm1 - K273A (1)
Pain Link Frequency Relevance Heat
opioid receptor 1542 100.00 Very High Very High Very High
Morphine 1166 100.00 Very High Very High Very High
agonist 158 100.00 Very High Very High Very High
mu opioid receptor 88 100.00 Very High Very High Very High
narcan 44 100.00 Very High Very High Very High
opiate 18 99.92 Very High Very High Very High
neuralgia 12 99.80 Very High Very High Very High
Spinal cord 39 99.68 Very High Very High Very High
Kinase C 370 99.64 Very High Very High Very High
Sciatic nerve 12 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 8 99.06 Very High Very High Very High
Hypoxia 5 98.84 Very High Very High Very High
Urological Neuroanatomy 198 89.20 High High
Drug Dependence 11 88.64 High High
Stress 3 87.64 High High
Neurodegenerative Disease 14 82.08 Quite High
Reperfusion Injury 1 80.80 Quite High
Cv Unclassified Under Development 1 80.04 Quite High
Opiate Addiction 20 77.60 Quite High
Parkinson's Disease 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylation of the mu-opioid receptor may play a role in opioid tolerance and dependence. 3-Isobutyl-1-methylxanthine (IBMX) was found to inhibit basal mu-opioid receptor phosphorylation (IC50 < or = 10 microM) either upon acute treatment or after 8 h pre-treatment in HEK293 cells transfected with the mu-opioid receptor.
Phosphorylation (Phosphorylation) of mu-opioid receptor associated with addiction, tolerance, opioid receptor and opioid
1) Confidence 0.82 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10355588 Disease Relevance 0 Pain Relevance 0.88
These results suggest a new effect of IBMX in inhibiting basal mu-opioid receptor phosphorylation, and provide additional evidence for the involvement of receptor phosphorylation in the development of opioid tolerance and dependence.
Phosphorylation (phosphorylation) of mu-opioid receptor associated with addiction, tolerance, opioid receptor and opioid
2) Confidence 0.82 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10355588 Disease Relevance 0 Pain Relevance 1.38
Phosphorylation of the mu-opioid receptor may play a role in opioid tolerance and dependence. 3-Isobutyl-1-methylxanthine (IBMX) was found to inhibit basal mu-opioid receptor phosphorylation (IC50 < or = 10 microM) either upon acute treatment or after 8 h pre-treatment in HEK293 cells transfected with the mu-opioid receptor.
Phosphorylation (phosphorylation) of mu-opioid receptor associated with addiction, tolerance, opioid receptor and opioid
3) Confidence 0.82 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10355588 Disease Relevance 0 Pain Relevance 1.09
Since it has been shown that PKA activity is enhanced in the brains of morphine-tolerant mice, this decrease in mu-receptor phosphorylation suggests that the mu-receptor may be structurally or conformationally altered in the morphine-tolerant state.
Phosphorylation (phosphorylation) of mu-receptor in brains associated with morphine
4) Confidence 0.80 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9582426 Disease Relevance 0 Pain Relevance 1.17
Chronic morphine administration resulted in a decrease in PKA-induced phosphorylation of the mu-receptor.
Phosphorylation (phosphorylation) of mu-receptor associated with morphine
5) Confidence 0.80 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9582426 Disease Relevance 0 Pain Relevance 1.22
These findings suggest that the phosphorylation of the mu-opioid receptor in the spinal cord under a neuropathic pain-like state may, at least in part, contribute to the reduction in the antinociceptive effect produced by morphine in the mouse.
Phosphorylation (phosphorylation) of mu-opioid receptor in spinal cord associated with neuropathic pain, opioid receptor, antinociceptive, morphine and spinal cord
6) Confidence 0.77 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 14698460 Disease Relevance 0.18 Pain Relevance 1.02
3-Isobutyl-1-methylxanthine inhibits basal mu-opioid receptor phosphorylation and reverses acute morphine tolerance and dependence in mice.
Phosphorylation (phosphorylation) of mu-opioid receptor associated with addiction, narcan, tolerance, opioid receptor and morphine
7) Confidence 0.63 Published 1999 Journal Eur. J. Pharmacol. Section Title Doc Link 10355588 Disease Relevance 0 Pain Relevance 1.46
In addition morphine also stimulated MOR associated PDGF-beta receptor phosphorylation.
Phosphorylation (phosphorylation) of MOR associated with mu opioid receptor and morphine
8) Confidence 0.63 Published 2006 Journal Current neurovascular research Section Abstract Doc Link 16918381 Disease Relevance 0 Pain Relevance 0.97
Results of radioligand binding and transfected receptor studies indicate that mu-receptor down-regulation and phosphorylation may be critical to the expression of morphine tolerance.
Phosphorylation (phosphorylation) of mu-receptor associated with tolerance and morphine
9) Confidence 0.62 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9582426 Disease Relevance 0 Pain Relevance 0.80
Increased phosphorylated-mu-opioid receptor immunoreactivity in the mouse spinal cord following sciatic nerve ligation.
Phosphorylation (phosphorylated) of mu-opioid receptor in spinal cord associated with neuralgia, sciatic nerve, opioid receptor and spinal cord
10) Confidence 0.59 Published 2004 Journal Neurosci. Lett. Section Title Doc Link 14698460 Disease Relevance 0.16 Pain Relevance 1.25
MOR is glycosylated when expressed in HEK 293 cells; however, analysis of N-glycosidase F-treated membranes indicated that N-glycan chains within the amino-terminal domain of MOR do not contribute significantly to ligand affinities.
Phosphorylation (glycosylated) of MOR associated with mu opioid receptor
11) Confidence 0.56 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10719216 Disease Relevance 0 Pain Relevance 0.90
mu-Opioid receptor down-regulation and cAMP-dependent protein kinase phosphorylation in a mouse model of chronic morphine tolerance.
Phosphorylation (phosphorylation) of mu-Opioid receptor associated with narcan, tolerance, opioid receptor and morphine
12) Confidence 0.54 Published 1998 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9582426 Disease Relevance 0 Pain Relevance 1.17
The present study was designed to determine whether a state of neuropathic pain induced by sciatic nerve ligation could alter phosphorylated-mu-opioid receptor-like immunoreactivity in the superficial dorsal horn of the mouse spinal cord.
Phosphorylation (phosphorylated) of mu-opioid receptor in sciatic nerve associated with dorsal horn, neuropathic pain, opioid receptor, sciatic nerve and spinal cord
13) Confidence 0.52 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 14698460 Disease Relevance 0.16 Pain Relevance 0.90
Under this condition, phosphorylated-mu-opioid receptor-like immunoreactivity was clearly increased on the ipsilateral side in the superficial laminae of the L5 lumbar spinal dorsal horn in nerve-ligated mice.
Phosphorylation (phosphorylated) of mu-opioid receptor in spinal associated with spinal dorsal horn and opioid receptor
14) Confidence 0.52 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 14698460 Disease Relevance 0.17 Pain Relevance 1.00
Tolerance to acute morphine developed as a result of phosphorylation of MOR cytosolic residues, uncoupling from the regulated G proteins which are transferred to RGSZ2 proteins.
Phosphorylation (phosphorylation) of MOR associated with tolerance, opioid receptor and morphine
15) Confidence 0.45 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.04
Similarly, the inhibition of CaMKII prevents MOR phosphorylation and reduces AMPAR function [80].
Phosphorylation (phosphorylation) of MOR associated with opioid receptor
16) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.11
to the MOR to promote the Src-mediated phosphorylation of the Tyr1325 NMDAR2A subunit.
Phosphorylation (phosphorylation) of MOR associated with opioid receptor
17) Confidence 0.44 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2890584 Disease Relevance 0.13 Pain Relevance 0.98
Analysis of MOR phosphorylation
Phosphorylation (phosphorylation) of MOR associated with opioid receptor
18) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.08 Pain Relevance 0.13
EM1/2 and Mor markedly improved mitochondrial respiratory activity with a decrease in state 4 and increases in state 3, respiratory control ratio (RCR) and the oxidative phosphorylation efficiency (ADP/O ratio), suggesting that they may play a protective role in mitochondria.
Phosphorylation (phosphorylation) of Mor in respiratory associated with morphine
19) Confidence 0.41 Published 2008 Journal Life Sci. Section Abstract Doc Link 18272183 Disease Relevance 0.95 Pain Relevance 0.55
The limited capacity of morphine to stimulate both Ser375 phosphorylation and MOR internalization could be due to its high off rate from the activated MOR.
Phosphorylation (phosphorylation) of MOR associated with morphine
20) Confidence 0.39 Published 2007 Journal Mol Pain Section Body Doc Link PMC1947952 Disease Relevance 0.15 Pain Relevance 1.40

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