INT62522

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Context Info
Confidence 0.13
First Reported 1996
Last Reported 1997
Negated 1
Speculated 1
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
opiate 3 100.00 Very High Very High Very High
agonist 15 99.78 Very High Very High Very High
Kinase C 3 99.02 Very High Very High Very High
tolerance 2 97.08 Very High Very High Very High
addiction 2 96.52 Very High Very High Very High
Morphine 4 94.84 High High
Immobilon 1 92.88 High High
Enkephalin 2 88.72 High High
mu opioid receptor 6 84.24 Quite High
methadone 3 83.52 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, basal phosphorylation was found to be Ca2+ dependent; however, several inhibitors of protein kinase C and Ca2+-calmodulin dependent kinases failed to affect basal mu receptor phosphorylation.
Neg (failed) Regulation (affect) of Phosphorylation (phosphorylation) of mu receptor associated with kinase c
1) Confidence 0.13 Published 1996 Journal FEBS Lett. Section Abstract Doc Link 8654566 Disease Relevance 0 Pain Relevance 0.43
The gradual agonist dependent modulation of basal mu receptor phosphorylation suggests a novel regulatory mechanism which may play a role in narcotic tolerance and dependence.
Regulation (modulation) of Phosphorylation (phosphorylation) of mu receptor associated with addiction, tolerance and agonist
2) Confidence 0.13 Published 1996 Journal FEBS Lett. Section Abstract Doc Link 8654566 Disease Relevance 0 Pain Relevance 0.47
To better understand the nature of the agonist-induced mu receptor phosphorylation events, we have investigated the effects of a variety of opiate ligands of varying potencies and intrinsic activities on mu receptor phosphorylation and desensitization.
Spec (investigated) Regulation (effects) of Phosphorylation (phosphorylation) of mu receptor associated with agonist and opiate
3) Confidence 0.02 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9360954 Disease Relevance 0 Pain Relevance 1.06

General Comments

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