INT62523

Context Info Confidence 0.53 First Reported 1996 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 11 Total Number 12 Disease Relevance 0.75 Pain Relevance 12.51

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)

Anatomy Link Frequency spinal 2 spinal cord 2 Oprm1 (Mus musculus)

Pain Link Frequency Relevance Heat opioid receptor 243 100.00 agonist 51 100.00 mu opioid receptor 40 100.00 Spinal cord 8 100.00 Neuropathic pain 4 100.00 Morphine 142 99.88 antagonist 21 99.56 Buprenorphine 12 99.14 methadone 18 99.12 antinociception 5 99.04

Disease Link Frequency Relevance Heat Neuropathic Pain 4 100.00 Pain 4 75.20 Opiate Addiction 10 72.44 Urological Neuroanatomy 18 63.28 Targeted Disruption 2 46.44 Neurodegenerative Disease 6 22.12 Pheochromocytoma 10 5.00 Nociception 7 5.00 Sprains And Strains 6 5.00 Intractable Pain 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition morphine also stimulated MOR associated PDGF-beta receptor phosphorylation.

Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of MOR associated with mu opioid receptor and morphine

1) Confidence 0.53 Published 2006 Journal Current neurovascular research Section Abstract Doc Link 16918381 Disease Relevance 0 Pain Relevance 0.97

These findings suggest that the phosphorylation of the mu-opioid receptor in the spinal cord under a neuropathic pain-like state may, at least in part, contribute to the reduction in the antinociceptive effect produced by morphine in the mouse.

Spec (may) Positive_regulation (contribute) of Phosphorylation (phosphorylation) of mu-opioid receptor in spinal cord associated with neuropathic pain, opioid receptor, antinociceptive, morphine and spinal cord

2) Confidence 0.47 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 14698460 Disease Relevance 0.18 Pain Relevance 1.02

Under this condition, phosphorylated-mu-opioid receptor-like immunoreactivity was clearly increased on the ipsilateral side in the superficial laminae of the L5 lumbar spinal dorsal horn in nerve-ligated mice.

Positive_regulation (increased) of Phosphorylation (phosphorylated) of mu-opioid receptor in spinal associated with spinal dorsal horn and opioid receptor

3) Confidence 0.38 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 14698460 Disease Relevance 0.17 Pain Relevance 1.01

to the MOR to promote the Src-mediated phosphorylation of the Tyr1325 NMDAR2A subunit.

Positive_regulation (mediated) of Phosphorylation (phosphorylation) of MOR associated with opioid receptor

4) Confidence 0.27 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2890584 Disease Relevance 0.13 Pain Relevance 0.98

Periplakin inhibits G-protein activation when MOR is bound by an agonist [18], while PCKI1 inhibits agonist-induced phosphorylation of MOR by G-protein coupled receptor kinase 2 [19].

Positive_regulation (induced) of Phosphorylation (phosphorylation) of MOR associated with agonist and opioid receptor

5) Confidence 0.23 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2841195 Disease Relevance 0.27 Pain Relevance 1.38

Pretreatment with the agonist morphine, followed by drug removal, resulted in a sustained increase of basal mu receptor phosphorylation.

Positive_regulation (increase) of Phosphorylation (phosphorylation) of mu receptor associated with agonist and morphine

6) Confidence 0.15 Published 1996 Journal FEBS Lett. Section Abstract Doc Link 8654566 Disease Relevance 0 Pain Relevance 0.47

Buprenorphine and full antagonists each antagonized the enhanced mu receptor phosphorylation induced by morphine or DAMGO.

Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of mu receptor associated with antagonist, morphine and buprenorphine

7) Confidence 0.03 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9360954 Disease Relevance 0 Pain Relevance 1.42

This generally good fit between the efficacies of opiates in mu receptor activation, phosphorylation, and desensitization supports the idea that activated receptor/agonist/G-protein complexes and/or receptor conformational changes induced by agonists are required for agonist-induced mu receptor phosphorylation.

Positive_regulation (required) of Phosphorylation (phosphorylation) of mu receptor associated with agonist and opiate

8) Confidence 0.03 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9360954 Disease Relevance 0 Pain Relevance 1.19

Buprenorphine and full antagonists each antagonized the enhanced mu receptor phosphorylation induced by morphine or DAMGO.

Positive_regulation (induced) of Phosphorylation (phosphorylation) of mu receptor associated with antagonist, morphine and buprenorphine

9) Confidence 0.03 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9360954 Disease Relevance 0 Pain Relevance 1.44

This generally good fit between the efficacies of opiates in mu receptor activation, phosphorylation, and desensitization supports the idea that activated receptor/agonist/G-protein complexes and/or receptor conformational changes induced by agonists are required for agonist-induced mu receptor phosphorylation.

Positive_regulation (induced) of Phosphorylation (phosphorylation) of mu receptor associated with agonist and opiate

10) Confidence 0.03 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9360954 Disease Relevance 0 Pain Relevance 1.18

To better understand the nature of the agonist-induced mu receptor phosphorylation events, we have investigated the effects of a variety of opiate ligands of varying potencies and intrinsic activities on mu receptor phosphorylation and desensitization.

Positive_regulation (agonist-induced) of Phosphorylation (phosphorylation) of mu receptor associated with agonist and opiate

11) Confidence 0.02 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9360954 Disease Relevance 0 Pain Relevance 0.83

Mu opioid receptors are subject to phosphorylation and desensitization through actions of at least two distinct biochemical pathways: agonist-dependent mu receptor phosphorylation and desensitization induced by a biochemically distinct second pathway dependent on protein kinase C activation (1).

Positive_regulation (induced) of Phosphorylation (phosphorylation) of mu receptor associated with kinase c, agonist and mu opioid receptor

12) Confidence 0.02 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9360954 Disease Relevance 0 Pain Relevance 0.61

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