INT62525

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Context Info
Confidence 0.70
First Reported 1995
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 38
Total Number 41
Disease Relevance 46.00
Pain Relevance 5.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SELE) cell adhesion (SELE) plasma membrane (SELE)
Anatomy Link Frequency
endothelial cells 5
endothelium 3
leukocyte 2
brain 1
platelet 1
SELE (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 7 99.44 Very High Very High Very High
Inflammatory stimuli 2 98.68 Very High Very High Very High
Neuropeptide 27 98.20 Very High Very High Very High
Angina 31 97.92 Very High Very High Very High
qutenza 4 97.60 Very High Very High Very High
cytokine 323 97.48 Very High Very High Very High
Neuritis 1 97.48 Very High Very High Very High
substance P 36 97.04 Very High Very High Very High
Inflammation 795 95.96 Very High Very High Very High
Inflammatory response 73 95.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 719 100.00 Very High Very High Very High
Myocardial Infarction 99 99.92 Very High Very High Very High
Pre-eclampsia 139 99.84 Very High Very High Very High
Endotoxemia 3 99.68 Very High Very High Very High
Injury 140 99.60 Very High Very High Very High
Coronary Artery Disease 423 99.48 Very High Very High Very High
Diabetes Mellitus 876 99.34 Very High Very High Very High
Nicotine Addiction 847 99.32 Very High Very High Very High
Cardiovascular Disease 83 98.98 Very High Very High Very High
Shock 23 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Patients with acute myocardial infarction had increased serum levels of soluble E-selectin (sE-selectin = 255 +/- 12 ng/ml) compared to both patients with angina pectoris (sE-selectin = 51 +/- 14 ng/ml).
Positive_regulation (increased) of E-selectin associated with angina and myocardial infarction
1) Confidence 0.70 Published 1995 Journal Int J Microcirc Clin Exp Section Abstract Doc Link 8655256 Disease Relevance 0.95 Pain Relevance 0.24
The discrepancies in these association studies also imply that changes trigerred by the mutation may be partly discernible from those resulting from elevated E-selectin levels.
Positive_regulation (elevated) of E-selectin
2) Confidence 0.59 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1933415 Disease Relevance 0.92 Pain Relevance 0
It is noteworthy that both CAD and DM2 are independently thought to be characterized by endothelial dysfunction [19,29,30], and an elevation in soluble E-selectin levels has been identified as a biomarker for both disorders.
Positive_regulation (elevation) of E-selectin associated with coronary artery disease and diabetes mellitus
3) Confidence 0.59 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1933415 Disease Relevance 1.35 Pain Relevance 0
While a large number of studies available in the literature have associated changes in DM2 or CAD primarily with either an increase in E-selectin levels or S128R polymorphism, only a few of these investigations have addressed this issue directly.
Positive_regulation (increase) of E-selectin associated with coronary artery disease and diabetes mellitus
4) Confidence 0.59 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1933415 Disease Relevance 1.23 Pain Relevance 0
Diclofenac also inhibited LPS-induced increases in E-selectin, ICAM-1 and VCAM-1 mRNAs, indicating that the action of diclofenac is to inhibit synthesis of these molecules.
Positive_regulation (increases) of E-selectin associated with diclofenac
5) Confidence 0.58 Published 1996 Journal Life Sci. Section Abstract Doc Link 8691982 Disease Relevance 0.33 Pain Relevance 0.38
Patients with acute myocardial infarction (AMI) had increased serum levels of soluble E-selectin (sE-selectin; AMI + urokinase = 312 +/- 20 ng/ml; AMI + nitroglycerin = 334 +/- 15 ng/ml) and soluble ICAM-1 (sICAM-1; AMI + urokinase = 629 +/- 30 ng/ml; AMI + nitroglycerin = 655 +/- 25 ng/ml) compared to both patients with chronic angina (sE-selectin = 67 +/- 10 ng/ml; sICAM-1 = 230 +/- 20 ng/ml) and healthy control subjects (sE-selectin = 53 +/- 15 ng/ml; sICAM-1 200 +/- 16 ng/ml).
Positive_regulation (increased) of soluble E-selectin associated with angina and myocardial infarction
6) Confidence 0.56 Published 1996 Journal Inflamm. Res. Section Abstract Doc Link 8821773 Disease Relevance 1.74 Pain Relevance 0.21
This study group observed increased levels of sELAM-1 over the study period in patients with sustained organ dysfunction and in non-survivors, whereas sELAM-1 levels decreased in patients whose organ dysfunction resolved [18].
Positive_regulation (increased) of sELAM-1
7) Confidence 0.54 Published 2005 Journal Crit Care Section Body Doc Link PMC1269435 Disease Relevance 0.92 Pain Relevance 0.11
For instance, elevated sE-selectin and sICAM-1 have been shown to activate leukocytes following neurological insult [24], whereas high sL-selectin levels are closely associated with decreased cellular interactions and reduced microvascular damage in critically injured patients [79].
Positive_regulation (elevated) of sE-selectin in leukocytes
8) Confidence 0.53 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.92 Pain Relevance 0.03
A number of the molecules which mediate leukocyte-endothelial adhesion have been identified; these include vascular cellular adhesion molecule-1 (VCAM-1), intracellular adhesion molecule-1 (ICAM-1) and E-selectin (4-6).
Positive_regulation (include) of E-selectin in leukocyte associated with adhesions
9) Confidence 0.48 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816332 Disease Relevance 1.20 Pain Relevance 0.12
Kitamura et al. [233] observed a significant increase in serum sE-selectin levels in heavy smokers (20–40 cigarettes day-1; 92 ng ml-1), compared to non-smokers (67 ng ml-1).
Positive_regulation (increase) of sE-selectin associated with nicotine addiction
10) Confidence 0.47 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.66 Pain Relevance 0
Kitamura et al. [233] observed a significant increase in serum sE-selectin levels in heavy smokers (20–40 cigarettes day-1; 92 ng ml-1), compared to non-smokers (67 ng ml-1).
Positive_regulation (increase) of sE-selectin associated with nicotine addiction
11) Confidence 0.47 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.66 Pain Relevance 0
The aim was to investigate circulating E-selectin and Intercellular Adhesion Molecule-1 (ICAM-1) in acute myocardial infarction.
Spec (investigate) Positive_regulation (circulating) of E-selectin associated with myocardial infarction and adhesions
12) Confidence 0.47 Published 1996 Journal Inflamm. Res. Section Abstract Doc Link 8821773 Disease Relevance 0.79 Pain Relevance 0.08
We investigated the induction of adhesion molecules such as L-selectin, E-selectin, ICAM-1, VCAM-1 and Mac-1 on Schwann cells by proinflammatory cytokines.
Spec (investigated) Positive_regulation (nduction ) of E-selectin in Schwann cells associated with adhesions and cytokine
13) Confidence 0.46 Published 1999 Journal J. Neurol. Sci. Section Abstract Doc Link 10561528 Disease Relevance 0.56 Pain Relevance 0.32
Patients with acute myocardial infarction had increased serum levels of soluble E-selectin (sE-selectin = 255 +/- 12 ng/ml) compared to both patients with angina pectoris (sE-selectin = 51 +/- 14 ng/ml).
Positive_regulation (increased) of sE-selectin associated with angina and myocardial infarction
14) Confidence 0.44 Published 1995 Journal Int J Microcirc Clin Exp Section Abstract Doc Link 8655256 Disease Relevance 0.95 Pain Relevance 0.24
To begin with, as mentioned above, an elevation in E-selectin levels appears to be a feature of certain groups of patients with CAD, restenosis as well as DM2.
Positive_regulation (elevation) of E-selectin associated with coronary artery disease, diabetes mellitus and cardiovascular disease
15) Confidence 0.40 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1933415 Disease Relevance 1.53 Pain Relevance 0
One study involving first degree relatives has indicated that soluble E-selectin levels are elevated in patients with DM2 carrying the 128R allele in comparison with their non-diabetic relatives [10].
Positive_regulation (elevated) of E-selectin associated with diabetes mellitus
16) Confidence 0.40 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1933415 Disease Relevance 1.60 Pain Relevance 0.09
While a number of studies have also associated elevated soluble E-selectin levels with this mutation and identified it as a risk factor for DM2 in general [14-16], others seem to point to a gender (female)-related association of the soluble E-selectin levels with the disease [17-21], independent of obesity and elevated levels of inflammatory markers or other cell-adhesion molecules.
Positive_regulation (elevated) of E-selectin associated with diabetes mellitus, inflammatory marker, obesity, disease and adhesions
17) Confidence 0.40 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1933415 Disease Relevance 1.59 Pain Relevance 0.04
Besides, it is still unclear whether the elevation in soluble E-selectin levels in such patients is directly linked to the S128R mutation or not.
Spec (whether) Positive_regulation (elevation) of E-selectin
18) Confidence 0.40 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1933415 Disease Relevance 1.54 Pain Relevance 0.04
Bersinger et al. (29) suggested that the level of E-selectin in the serum of preeclamptic women was within normal pregnancy ranges, whereas Bretelle et al. (30) reported that sE-selectin was significantly increased in preeclampsia compared with the normal controls.
Positive_regulation (increased) of sE-selectin associated with pre-eclampsia
19) Confidence 0.38 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816332 Disease Relevance 1.15 Pain Relevance 0.07
For sE-selectin level, the mean value was significantly elevated in both mild (52.40±27.42 ng/mL, p=0.011) and severe preeclampsia (61.94±36.8 ng/mL, p=0.000) compared with normal pregnancy group (33.94±16) (Fig. 1C).
Positive_regulation (elevated) of sE-selectin associated with pre-eclampsia
20) Confidence 0.38 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816332 Disease Relevance 1.08 Pain Relevance 0

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