INT62526

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Context Info
Confidence 0.51
First Reported 1995
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 15.24
Pain Relevance 4.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SELE) cell adhesion (SELE) plasma membrane (SELE)
Anatomy Link Frequency
endothelial cells 1
synovium 1
SELE (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 127 100.00 Very High Very High Very High
Inflammatory response 16 100.00 Very High Very High Very High
abatacept 119 99.98 Very High Very High Very High
Infliximab 15 99.98 Very High Very High Very High
methotrexate 31 99.70 Very High Very High Very High
Inflammation 258 99.62 Very High Very High Very High
Pain 28 99.16 Very High Very High Very High
rheumatoid arthritis 322 96.60 Very High Very High Very High
antagonist 37 95.20 Very High Very High Very High
Osteoarthritis 70 94.64 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 275 100.00 Very High Very High Very High
Adhesions 99 100.00 Very High Very High Very High
Cancer 39 99.76 Very High Very High Very High
Necrosis 19 99.52 Very High Very High Very High
Pain 25 99.16 Very High Very High Very High
Sepsis 134 97.56 Very High Very High Very High
Pulmonary Disease 206 97.08 Very High Very High Very High
Arthritis 115 97.08 Very High Very High Very High
Asthma 16 96.72 Very High Very High Very High
Diarrhoea 4 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thrombolytic therapy with urokinase (1,000,000 IU as an intravenous bolus in 5 min, followed by producing reperfusion and reduced the serum levels of sE-selectin (71 +/- 19 ng/ml).
Negative_regulation (reduced) of sE-selectin
1) Confidence 0.51 Published 1995 Journal Int J Microcirc Clin Exp Section Abstract Doc Link 8655256 Disease Relevance 0.88 Pain Relevance 0.22
Thrombolytic therapy with urokinase (1,000,000 IU as an intravenous bolus for 5 minutes, followed by an infusion of an additional 1,000,000 IU for the following two hours) succeeded in producing reperfusion and reduced the serum levels of sE-selectin (52 +/- 13 ng/ml) and sICAM-1 (202 +/- 31 ng/ml).
Negative_regulation (reduced) of sE-selectin
2) Confidence 0.47 Published 1996 Journal Inflamm. Res. Section Abstract Doc Link 8821773 Disease Relevance 1.03 Pain Relevance 0.11
In contrast patients not eligible for thrombolytic therapy and therefore treated with conventional therapy (a continuous i.v. infusion of nitroglycerin at the dose of 50 mg/die) did not show any significant reduction in both sE-selectin and sICAM-1 throughout the study.
Negative_regulation (reduction) of sE-selectin
3) Confidence 0.47 Published 1996 Journal Inflamm. Res. Section Abstract Doc Link 8821773 Disease Relevance 0.80 Pain Relevance 0.09
Moreover, during 24 hours incubation we have investigated the production of endothelin 1 (ET-1), E-selectin and Interleukin 8 (IL-8) and it appears that ozonation enhances IL-8, inhibits E-selectin and hardly modifies ET-1 production.
Negative_regulation (inhibits) of E-selectin
4) Confidence 0.35 Published 2000 Journal Mediators Inflamm Section Abstract Doc Link PMC1781775 Disease Relevance 0.21 Pain Relevance 0.16
This study group observed increased levels of sELAM-1 over the study period in patients with sustained organ dysfunction and in non-survivors, whereas sELAM-1 levels decreased in patients whose organ dysfunction resolved [18].
Negative_regulation (decreased) of sELAM-1
5) Confidence 0.34 Published 2005 Journal Crit Care Section Body Doc Link PMC1269435 Disease Relevance 0.87 Pain Relevance 0.14
The authors also demonstrated that sELAM-1 decreased over time in septic patients while sICAM-1 increased further [11].
Negative_regulation (decreased) of sELAM-1
6) Confidence 0.34 Published 2005 Journal Crit Care Section Body Doc Link PMC1269435 Disease Relevance 0.99 Pain Relevance 0.09
Recently, 2-pyrocatechuic acid was found to be weak inhibitor of Selectin E [53] and potent inhibitor of 15-lipogygenase-catalysed oxygenation of arachidonic acid that is involved in many aspects of inflammatory disease and in particular in the development of colorectal cancer [54].
Negative_regulation (inhibitor) of Selectin E associated with inflammation, colon cancer and disease
7) Confidence 0.20 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2948926 Disease Relevance 0.82 Pain Relevance 0.20
plus methotrexate significantly decreases serum IL-18, E-selectin, TIMP1 and MMP9 levels [53].
Negative_regulation (decreases) of E-selectin associated with methotrexate
8) Confidence 0.16 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.53 Pain Relevance 0.22
NO produced by endothelial cells also has anti-inflammatory effects, which include a decrease in soluble vascular cell and intercellular adhesion molecules-1, E-selectin, and tumor necrosis factor ?
Negative_regulation (decrease) of E-selectin in endothelial cells associated with necrosis, inflammation, cancer and adhesions
9) Confidence 0.14 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2599761 Disease Relevance 1.39 Pain Relevance 0.05
In another study, anti-TNF treatment with the antibody infliximab decreases serum E-selectin and ICAM-1 levels, suggesting that this may reflect diminished activation of endothelial cells in the synovium, leading to reduced migration of leukocytes into human RA joints [39].
Negative_regulation (decreases) of E-selectin in synovium associated with infliximab and rheumatoid arthritis
10) Confidence 0.09 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 1.60 Pain Relevance 0.55
At the doses of 2 mg/kg or 10 mg/kg used in further clinical studies, abatacept decreased serum levels of proinflammatory cytokines and inflammatory responses, including soluble IL-2 receptor, IL-6, E-selectin, TNF-alfa, rheumatoid factor, and C-reactive protein levels (Weisman et al. 2006).
Negative_regulation (decreased) of E-selectin associated with inflammatory response, abatacept and cytokine
11) Confidence 0.07 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012435 Disease Relevance 0.53 Pain Relevance 0.64
treatment reduces endothelial E-selectin and vascular cell adhesion molecule-1 in synovial samples, as well as the levels of E-selectin, intercellular adhesion molecule-1, IL-8 and vascular endothelial growth factor in the circulation [129].
Negative_regulation (reduces) of E-selectin associated with adhesions
12) Confidence 0.04 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130001 Disease Relevance 0.78 Pain Relevance 0.16
Reduction in expression of endothelial adhesion molecules (ICAM-1, VCAM-1, E-selectin and P-selectin) also contributes to the anti-inflammatory effect (Seljeflot et al 2002).
Negative_regulation (Reduction) of E-selectin associated with inflammation and adhesions
13) Confidence 0.02 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546474 Disease Relevance 0.83 Pain Relevance 0.26
Several adhesion molecules can now be inhibited pharmacologically, and among these inhibitors, bimosiamose is the leading selectin inhibitor in clinical development (Davenpeck et al 2000; Romano 2005).


Negative_regulation (inhibitor) of selectin associated with adhesions
14) Confidence 0.01 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629979 Disease Relevance 1.35 Pain Relevance 0.41
An additional mechanism of its anti-inflammatory effect may be via suppression of adhesion molecules E-selectin, ICAM-1 and VCAM-1 (67).
Negative_regulation (suppression) of E-selectin associated with inflammation and adhesions
15) Confidence 0.01 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193557 Disease Relevance 1.10 Pain Relevance 0.42
However paradoxically others have argued that selectin blockade may actually reduce pain relief.32 Further clinical trials and laboratory investigations are necessary to elucidate its mechanism of action.
Negative_regulation (blockade) of selectin associated with pain
16) Confidence 0.01 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2846142 Disease Relevance 0.41 Pain Relevance 0.26
Another selectin inhibitor, the imidazole compound OC 229648, is under evaluation for treatment of COPD and asthma (Romano and Slee 2001).
Negative_regulation (inhibitor) of selectin associated with asthma and pulmonary disease
17) Confidence 0.01 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 1.12 Pain Relevance 0.22

General Comments

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