INT62543

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1996
Last Reported 2010
Negated 10
Speculated 3
Reported most in Abstract
Documents 231
Total Number 234
Disease Relevance 187.58
Pain Relevance 52.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
endothelial cells 19
monocyte 11
lung 10
macrophages 9
neutrophil 9
Icam1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 3605 100.00 Very High Very High Very High
chemokine 770 100.00 Very High Very High Very High
metalloproteinase 498 100.00 Very High Very High Very High
Central nervous system 413 100.00 Very High Very High Very High
allodynia 14 100.00 Very High Very High Very High
cytokine 1488 99.92 Very High Very High Very High
Sciatic nerve 273 99.92 Very High Very High Very High
dexamethasone 21 99.92 Very High Very High Very High
ischemia 454 99.82 Very High Very High Very High
antagonist 180 99.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 4003 100.00 Very High Very High Very High
Adhesions 1813 100.00 Very High Very High Very High
Cancer 915 100.00 Very High Very High Very High
Apoptosis 691 100.00 Very High Very High Very High
Necrosis 234 100.00 Very High Very High Very High
Neuropathic Pain 20 100.00 Very High Very High Very High
Multiple Sclerosis 616 99.96 Very High Very High Very High
Cardiovascular Disease 177 99.96 Very High Very High Very High
Pressure And Volume Under Development 150 99.90 Very High Very High Very High
Injury 1958 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The initial step in atherosclerosis is the adhesion of leukocytes to activated endothelial cells mediated by intracellular adhesion molecule-1 (ICAM-1).2 Soluble ICAM-1 (sICAM-1) is a circulating form of ICAM-1 and has been shown to reflect cell surface expression of ICAM-1 in human vascular endothelial cells.
Gene_expression (expression) of ICAM-1 in endothelial cells associated with atherosclerosis and adhesions
1) Confidence 0.78 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 1.89 Pain Relevance 0.19
Rebamipide reduces indomethacin-induced gastric injury in mice via down-regulation of ICAM-1 expression.
Gene_expression (expression) of ICAM-1 associated with injury
2) Confidence 0.78 Published 2005 Journal Dig. Dis. Sci. Section Title Doc Link 16184426 Disease Relevance 0.83 Pain Relevance 0.29
Therefore, rebamipide may reduce indomethacin-induced gastric mucosal injuries through its antioxidant effect, which inhibits the neutrophil activation step following up-regulation of ICAM-1 expression on endothelial cells.
Gene_expression (expression) of ICAM-1 in endothelial cells associated with injury
3) Confidence 0.78 Published 2005 Journal Dig. Dis. Sci. Section Abstract Doc Link 16184426 Disease Relevance 0.72 Pain Relevance 0.17
Furthermore, rebamipide pre-treatment notably decreased intercellular adhesion molecule-1 (ICAM-1) expression that was up-regulated in gastric tissue treated with indomethacin.
Gene_expression (expression) of ICAM-1 associated with adhesions
4) Confidence 0.78 Published 2005 Journal Dig. Dis. Sci. Section Abstract Doc Link 16184426 Disease Relevance 0.80 Pain Relevance 0.20
Furthermore, rebamipide pre-treatment notably decreased intercellular adhesion molecule-1 (ICAM-1) expression that was up-regulated in gastric tissue treated with indomethacin.
Gene_expression (expression) of intercellular adhesion molecule-1 associated with adhesions
5) Confidence 0.78 Published 2005 Journal Dig. Dis. Sci. Section Abstract Doc Link 16184426 Disease Relevance 0.81 Pain Relevance 0.21
Elevated concentrations of ICAM-1 were reported to be associated with an increased risk of stroke 6 whereas no correlation was found between the expression of ICAM-1 and the severity of symptomatic carotid disease 26.
Gene_expression (expression) of ICAM-1 associated with stroke and disease
6) Confidence 0.73 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 0.67 Pain Relevance 0.03
Of these, increased expression of P-selectin, ICAM-1 and CCL12 after carrageenan injection could be verified by real-time RT-PCR on both the right and left sides, and increased in P-selectin and ICAM-1 further verified by Western blot analysis.
Gene_expression (expression) of ICAM-1
7) Confidence 0.71 Published 2009 Journal Pain Section Abstract Doc Link 19167818 Disease Relevance 0.58 Pain Relevance 0.44
This opposite modulatory role of interleukin-1 and dexamethasone on intercellular adhesion molecule-1 expression was also, for the first time, observed in vivo using mouse peritoneal macrophages: a four-fold increase in intercellular adhesion molecule-1 expression was measured after local administration of the cytokine (5 micrograms/kg) and this effect was greatly inhibited (> 70%) by co-injection with 1 microgram dexamethasone.
Gene_expression (expression) of intercellular adhesion molecule-1 in peritoneal macrophages associated with dexamethasone, adhesions and cytokine
8) Confidence 0.71 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8660354 Disease Relevance 0.44 Pain Relevance 0.30
Differential spinal expression of major histocompatibility complex (MHC) class II, platelet-endothelial cellular adhesion molecule (PECAM), intercellular adhesion molecule (ICAM) and CD4 was observed in the two injury models.
Gene_expression (expression) of intercellular adhesion molecule in platelet associated with injury and adhesions
9) Confidence 0.70 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960644 Disease Relevance 1.04 Pain Relevance 0.56
Differential spinal expression of major histocompatibility complex (MHC) class II, platelet-endothelial cellular adhesion molecule (PECAM), intercellular adhesion molecule (ICAM) and CD4 was observed in the two injury models.
Gene_expression (expression) of ICAM in platelet associated with injury and adhesions
10) Confidence 0.70 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960644 Disease Relevance 1.04 Pain Relevance 0.57
The expression of ICAM-1 on endothelial cells was examined using acetone-fixed cryosections of the tissue.
Gene_expression (expression) of ICAM in endothelial cells
11) Confidence 0.68 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 0.34 Pain Relevance 0
ICAM-1 is constitutively expressed at a low concentration; however, under inflammatory conditions it is highly inducible in many cell types [7].
Gene_expression (expressed) of ICAM associated with inflammation
12) Confidence 0.68 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 1.05 Pain Relevance 0.18
However, liver, due to its large endothelial cell content, serves as an excellent tissue source for ICAM-1 expression.
Gene_expression (expression) of ICAM in endothelial cell
13) Confidence 0.68 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 0.38 Pain Relevance 0
In contrast, ICAM-1 expression was absent in the tissues of P/I null mice before and after CLP treatment (Figure 1, P/I CT, 6 h and 24 h).
Neg (absent) Gene_expression (expression) of ICAM
14) Confidence 0.68 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 0.24 Pain Relevance 0
Similarly, ICAM-1 expression was identified using a specific monoclonal antibody to mouse ICAM-1 (3E2 clone, PharmMingen, San Diego, CA) and a biotin-conjugated secondary antibody.
Gene_expression (expression) of ICAM
15) Confidence 0.68 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 0.31 Pain Relevance 0
Cd-induced ICAM-1 expression and leukocyte-EC adhesion were diminished by non-steroidal anti-inflammatory drugs such as indomethacin and NS-398, which was reversed by addition of PGE(2).
Gene_expression (expression) of ICAM-1 in leukocyte associated with inflammation, cinod and adhesions
16) Confidence 0.67 Published 2006 Journal Toxicol. Lett. Section Abstract Doc Link 16777358 Disease Relevance 0.35 Pain Relevance 0.10
COX-2 is associated with cadmium-induced ICAM-1 expression in cerebrovascular endothelial cells.
Gene_expression (expression) of ICAM-1 in endothelial cells associated with cox2
17) Confidence 0.67 Published 2006 Journal Toxicol. Lett. Section Title Doc Link 16777358 Disease Relevance 0.30 Pain Relevance 0.12
Together, these data suggest that Cd induces COX-2 expression through the activation of p38 MAPK, an oxidative stress-sensitive cellular signaling molecule, and induction of COX-2 is associated with ICAM-1 expression in brain endothelial cells following Cd exposure.
Gene_expression (expression) of ICAM-1 in brain associated with stress
18) Confidence 0.67 Published 2006 Journal Toxicol. Lett. Section Abstract Doc Link 16777358 Disease Relevance 0.34 Pain Relevance 0.09
Immunohistochemistry for ICAM-1 expression and neutrophil sequestration
Gene_expression (expression) of ICAM-1 in neutrophil
19) Confidence 0.67 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1891280 Disease Relevance 0.16 Pain Relevance 0.03
ICAM-1 was constitutively expressed in the wild-type control mice as indicated by brown staining along endothelial lining of the sinusoids, and hepatic vasculatures (Figure 1A).
Gene_expression (expressed) of ICAM-1 in vasculatures
20) Confidence 0.67 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1891280 Disease Relevance 0.29 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox