INT62544

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 1996
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 13.56
Pain Relevance 9.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein binding, bridging (Anxa1) cilium (Anxa1) protein complex (Anxa1)
cytoplasm (Anxa1) extracellular space (Anxa1) signal transduction (Anxa1)
Anatomy Link Frequency
cerebrospinal fluid 2
nerve 2
dorsal root 1
U-937 1
sciatic nerve 1
Anxa1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 306 99.92 Very High Very High Very High
Dorsal horn 37 99.62 Very High Very High Very High
Pain 152 99.52 Very High Very High Very High
qutenza 49 98.84 Very High Very High Very High
Sciatic nerve 146 98.60 Very High Very High Very High
Neuropathic pain 304 97.04 Very High Very High Very High
withdrawal 214 96.96 Very High Very High Very High
allodynia 107 96.24 Very High Very High Very High
Central nervous system 9 96.20 Very High Very High Very High
Hyperalgesia 45 95.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 217 99.86 Very High Very High Very High
Injury 73 99.82 Very High Very High Very High
Adhesions 5 99.70 Very High Very High Very High
Pain 168 99.52 Very High Very High Very High
Hypersensitivity 307 99.20 Very High Very High Very High
Breast Cancer 46 97.76 Very High Very High Very High
Neuropathic Pain 427 97.04 Very High Very High Very High
Hyperalgesia 86 95.96 Very High Very High Very High
Ovarian Cancer 31 91.36 High High
Demyelinating Disease 198 88.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differentiation of U-937 cells with phorbol ester (10 nM) induced a time-dependent (24 h or 48 h) increase of adhesion molecules and lipocortin 1 expression on the cell surface.
Gene_expression (expression) of lipocortin 1 in U-937 associated with adhesions
1) Confidence 0.47 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8660354 Disease Relevance 0.31 Pain Relevance 0.11
This fact may be explained by the possibility that the LPA converted from LPC by ATX causes a new synthesis of LPC and this cycle occurs several times over 3 h.
Gene_expression (synthesis) of LPC
2) Confidence 0.06 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.31 Pain Relevance 0.34
A similar level and time-course of LPA synthesis was observed following LPC injection (1 nmol, i.t.).
Gene_expression (injection) of LPC
3) Confidence 0.06 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.17 Pain Relevance 0.17
At different time-points (see Results for details) after the injection of LPC or LPA, mice were anesthetized by pentobarbital (50 mg/kg, i.p.).
Gene_expression (injection) of LPC
4) Confidence 0.06 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.39 Pain Relevance 0.29
LPC and LPA were dissolved in artificial cerebrospinal fluid (aCSF: NaCl 125 mM, KCl 3.8 mM, KH2PO4 1.2 mM, NaHCO3 26 mM, glucose 10 mM) when they were used in vivo.
Gene_expression (dissolved) of LPC in cerebrospinal fluid
5) Confidence 0.06 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0 Pain Relevance 0
Interestingly, the LPA levels in the SC and DR of atx+/- mice at 3 h were both below 4% of WT mice (Fig. 2b), while LPC-induced LPA production in the SC and DR was completely absent in Lpar3-/- mice, but not in Lpar1-/- or Lpar2-/- mice (Fig. 2c and 2d).
Neg (absent) Gene_expression (production) of LPC associated with spinal cord
6) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.12 Pain Relevance 0.44
Furthermore we demonstrated that intense stimulation of spinal cord slices with pain transmitters or capsaicin, which is thought to release pain transmitters, caused a biosynthesis of LPC.
Gene_expression (biosynthesis) of LPC in spinal cord associated with pain, qutenza and spinal cord
7) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 1.08 Pain Relevance 1.14
Finally, it should be noted that LPA-induced de novo LPC (or converted LPA) synthesis in SC and DR was completely absent in Lpar3-/- mice, but not in Lpar1-/- and Lpar2-/- mice, though LPA1, LPA2 and LPA3 receptors were all expressed in SC and DR.
Neg (absent) Gene_expression (synthesis) of LPC associated with spinal cord
8) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.45 Pain Relevance 0.35
g LPC injection (Additional file 2).
Gene_expression (injection) of LPC
9) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.40 Pain Relevance 0.10
g LPC but not with the 30 ?
Gene_expression (but) of LPC
10) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.51 Pain Relevance 0.05
g LPC was less than at 60 ?
Gene_expression (was) of LPC
11) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.45 Pain Relevance 0.05
Intra-plantar injection of LPC (30-100 ?
Gene_expression (injection) of LPC
12) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.53 Pain Relevance 0.05
LPC) produced by PLA2 activity can also activate TRPM8.
Gene_expression (produced) of LPC
13) Confidence 0.04 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2822744 Disease Relevance 0.09 Pain Relevance 0.05
There are reports that LPC is produced under physiological and pathological conditions [18,19].
Gene_expression (produced) of LPC
14) Confidence 0.04 Published 2008 Journal Mol Pain Section Body Doc Link PMC2277392 Disease Relevance 1.02 Pain Relevance 0.73
On the other hand, LPC is not present in CSF [22].
Neg (not) Gene_expression (present) of LPC in CSF
15) Confidence 0.04 Published 2008 Journal Mol Pain Section Body Doc Link PMC2277392 Disease Relevance 1.32 Pain Relevance 0.93
Therefore, nerve injury would produce LPC in the spinal cord, which would subsequently be hydrolyzed by ATX to form LPA.
Gene_expression (produce) of LPC in nerve associated with nervous system injury and spinal cord
16) Confidence 0.04 Published 2008 Journal Mol Pain Section Body Doc Link PMC2277392 Disease Relevance 1.36 Pain Relevance 0.97
Experiments to evaluate LPA and LPC production following nerve injury and clarify the relationship of ATX to LPA production are the next important issues to be addressed.
Gene_expression (production) of LPC in nerve associated with nervous system injury
17) Confidence 0.04 Published 2008 Journal Mol Pain Section Body Doc Link PMC2277392 Disease Relevance 1.39 Pain Relevance 0.96
Furthermore, we demonstrated that the injury-induced synthesis of LPC and subsequent conversion to LPA are both involved in the development of neuropathic pain [10,11].
Gene_expression (synthesis) of LPC associated with injury and neuropathic pain
18) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC2989310 Disease Relevance 1.41 Pain Relevance 0.93
LPC may be also produced at the dorsal root, where it is converted to LPA; 3) LPA binds to LPA1 receptors, resulting in retraction of peptidergic unmyelinated C-fibers.
Gene_expression (produced) of LPC in dorsal root associated with c fibre and unmyelinated
19) Confidence 0.01 Published 2008 Journal Mol Pain Section Body Doc Link PMC2365930 Disease Relevance 1.05 Pain Relevance 1.02
Altogether, we propose a hypothesis for mechanisms of neuropathic hyperalgesia and allodynia after partial sciatic nerve injury (Fig. 6) as follows: 1) intense stimulation of sensory neurons after sciatic nerve injury activates target neurons in the dorsal horn to induce de novo biosynthesis of LPC, which is in turn converted to LPA by ATX/LPLD; 2) LPA is then produced at the dorsal root fibers proximal to the spinal cord.
Gene_expression (biosynthesis) of LPC in sciatic nerve associated with hyperalgesia, nervous system injury, allodynia, neuropathic pain, dorsal horn, sciatic nerve and spinal cord
20) Confidence 0.01 Published 2008 Journal Mol Pain Section Body Doc Link PMC2365930 Disease Relevance 1.10 Pain Relevance 1.00

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox